Department of Clinical and Translational Science

Research Output

2020

A systematic review of penetrating extracranial vertebral artery injuries

Asensio, J. A., Dabestani, P. J., Wenzl, F. A., Miljkovic, S. S., Kessler, J. J., Fernandez, C. A., Becker, T., Cornell, D., Siu, M., Voigt, C. & Agrawal, D. K., Jan 1 2020, (Accepted/In press) In : Journal of Vascular Surgery.

Research output: Contribution to journalReview article

Infarct Zone: a Novel Platform for Exosome Trade in Cardiac Tissue Regeneration

Thankam, F. G. & Agrawal, D. K., Jan 1 2020, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalReview article

2019

Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease: Metabolic Syndrome or Independent Sequelae?

Satish, M., Saxena, S. K. & Agrawal, D. K., Jan 1 2019, In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalReview article

1 Scopus citations

An update on PTEN modulators–a patent review

Boosani, C. S., Gunasekar, P. & Agrawal, D. K., Nov 2 2019, In : Expert Opinion on Therapeutic Patents. 29, 11, p. 881-889 9 p.

Research output: Contribution to journalReview article

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition

Satish, M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalReview article

Corrigendum: Discovery of Novel and Clinically Relevant Markers in Formalin-Fixed Paraffin-Embedded Esophageal Cancer Specimen (Front. Oncol (2018) 8 (157) DOI: 10.3389/fonc.2018.00157)

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 273.

Research output: Contribution to journalComment/debate

Open Access

Epigenetic mechanisms and implications in tendon inflammation (Review)

Thankam, F. G., Boosani, C. S., Dilisio, M. & Agrawal, D. K., Jan 1 2019, In : International Journal of Molecular Medicine. 43, 1, p. 3-14 12 p.

Research output: Contribution to journalReview article

1 Scopus citations

Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation

Rosenberg, J. H., Werner, J. H., Plitt, G. D., Noble, V. V., Spring, J. T., Stephens, B. A., Siddique, A., Merritt-Genore, H. L., Moulton, M. J. & Agrawal, D. K., Mar 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

1 Scopus citations

Matrix regeneration proteins in the hypoxia-triggered exosomes of shoulder tenocytes and adipose-derived mesenchymal stem cells

Thankam, F. G., Chandra, I., Diaz, C., Dilisio, M. F., Fleegel, J., Gross, R. M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine

Gunasekar, P., Satish, M., Dabestani, P., Jiang, W., Boosani, C., Radwan, M., Agrawal, D. K. & Asensio, J. A., Nov 1 2019, In : Journal of Surgical Research. 243, p. 460-468 9 p.

Research output: Contribution to journalArticle

Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia

Thankam, F. G., Palanikumar, G., Fitzgibbons, R. J. & Agrawal, D. K., Apr 1 2019, In : Journal of Surgical Research. 236, p. 134-143 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias

Larsen, N. K., Reilly, M. J., Thankam, F. G., Fitzgibbons, R. J. & Agrawal, D. K., Jul 3 2019, In : Expert Review of Clinical Immunology. 15, 7, p. 791-800 10 p.

Research output: Contribution to journalReview article

Pro-inflammatory and pro-resolving mechanisms in the immunopathology of arteriovenous fistula maturation

Satish, M., Gunasekar, P. & Agrawal, D. K., May 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 5, p. 369-376 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases

Satish, M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Expert Review of Cardiovascular Therapy.

Research output: Contribution to journalArticle

5 Scopus citations

Therapeutic potential of exosomes in rotator cuff tendon healing

Connor, D. E., Paulus, J. A., Dabestani, P. J., Thankam, F. K., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2019, In : Journal of Bone and Mineral Metabolism.

Research output: Contribution to journalReview article

2018

All in one hydrogel approach: A translationally-worthwhile scenario for rotator cuff tendinopathies

Thankam, F. G., Dilisio, M. & Agrawal, D. K., Jul 25 2018, In : Trends in Biomaterials and Artificial Organs. 32, 1, p. 46-48 3 p.

Research output: Contribution to journalArticle

Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury

Thankam, F. G., Chandra, I. S., Kovilam, A. N., Diaz, C. G., Volberding, B. T., Dilisio, M., Radwan, M. M., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 17027.

Research output: Contribution to journalArticle

3 Scopus citations

Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon

Thankam, F. G., Roesch, Z. K., Dilisio, M., Radwan, M. M., Kovilam, A., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 8918.

Research output: Contribution to journalArticle

17 Scopus citations

Brain injury and neural stem cells

Ludwig, P. E., Thankam, F. G., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., Jan 1 2018, In : Neural Regeneration Research. 13, 1, p. 7-18 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

Cell-specific histone modifications in atherosclerosis (Review)

Jiang, W., Agrawal, D. K. & Boosani, C. S., Aug 1 2018, In : Molecular Medicine Reports. 18, 2, p. 1215-1224 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

Collagen I: A kingpin for rotator cuff tendon pathology

Thankam, F. G., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3291-3309 19 p., AJTR0079000.

Research output: Contribution to journalReview article

3 Scopus citations

Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis

Thankam, F. G., Evan, D. K., Agrawal, D. K. & Dilisio, M., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning

Rosenberg, J. H., Werner, J. H., Moulton, M. J. & Agrawal, D. K., May 24 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research. p. 1-16 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Delivery of viral vectors for gene therapy in intimal hyperplasia and restenosis in atherosclerotic swine

Hall, S. & Agrawal, D. K., Aug 1 2018, In : Drug Delivery and Translational Research. 8, 4, p. 918-927 10 p.

Research output: Contribution to journalReview article

3 Scopus citations

Discovery of novel and clinically relevant markers in formalin-fixed paraffin-embedded esophageal cancer specimen

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., May 9 2018, In : Frontiers in Oncology. 8, MAY, 157.

Research output: Contribution to journalArticle

FacIle syntheses and molecular-docking of novel substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide/ carbohydrazide Analogues with antimicrobial and antifungal properties

Bhosale, J. D., Dabur, R., Jadhav, G. & Bendre, R. S., Jan 1 2018, In : Molecules. 23, 4, 875.

Research output: Contribution to journalArticle

2 Scopus citations

From cord to caudate: Characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain

Maillacheruvu, P. F., Engel, L. M., Crum, I. T., Agrawal, D. K. & Peeples, E. S., Jan 1 2018, In : Pediatric Research. 83, 1-2, p. 205-213 9 p.

Research output: Contribution to journalReview article

2 Scopus citations

Genes interconnecting AMPK and TREM-1 and associated microRNAs in rotator cuff tendon injury

Thankam, F. G., Boosani, C. S., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

1 Scopus citations

Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine

Werner, J. H., Rosenberg, J. H., Keeley, K. L. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Clinical Immunology. 14, 8, p. 695-706 12 p.

Research output: Contribution to journalReview article

Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches

Addula, M., Wilson, V. E. D., Reddymasu, S. & Agrawal, D. K., Oct 3 2018, In : Expert Review of Clinical Immunology. 14, 10, p. 831-840 10 p.

Research output: Contribution to journalReview article

Immunotherapy plus cryotherapy: Potential augmented abscopal effect for advanced cancers

Abdo, J., Cornell, D. L., Mittal, S. K. & Agrawal, D. K., Mar 28 2018, In : Frontiers in Oncology. 8, MAR, 85.

Research output: Contribution to journalReview article

17 Scopus citations

Inhibition of DNA methyltransferase-1 instigates the expression of DNA methyltransferase-3a in angioplasty-induced restenosis

Boosani, C. S., Gunasekar, P., Block, M., Jiang, W., Zhang, Z., Radwan, M. M. & Agrawal, D. K., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 10, p. 1030-1039 10 p.

Research output: Contribution to journalArticle

Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction

Plitt, G. D., Spring, J. T., Moulton, M. J. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Cardiovascular Therapy. 16, 8, p. 579-589 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

Molecular discoveries and treatment strategies by direct reprogramming in cardiac regeneration

Werner, J. H., Rosenberg, J. H., Um, J. Y., Moulton, M. J. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

3 Scopus citations

Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to Clinical Translation

Karagiannis, A. D., Liu, M., Toth, P. P., Zhao, S., Agrawal, D. K., Libby, P. & Chatzizisis, Y. S., Apr 1 2018, In : Current Atherosclerosis Reports. 20, 4, 20.

Research output: Contribution to journalReview article

9 Scopus citations

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma

Singhal, S., Kapoor, H., Subramanian, S., Agrawal, D. K. & Mittal, S. K., Jan 1 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Rejuvenation of “broken heart” with bioengineered gel

Agrawal, D. K. & Siddique, A., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Vitamin D and macrophage polarization in epicardial adipose tissue of atherosclerotic swine

Gunasekar, P., Swier, V. J., Fleegel, J. P., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Oct 1 2018, In : PLoS One. 13, 10, e0199411.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Alterations in tendon microenvironment in response to mechanical load: Potential molecular targets for treatment strategies

Fouda, M. B., Thankam, F. G., Dilisio, M. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 10, p. 4341-4360 20 p., AJTR0059913.

Research output: Contribution to journalReview article

7 Scopus citations

Basis for molecular diagnostics and immunotherapy for esophageal cancer

Abdo, J., Agrawal, D. K. & Mittal, S. K., Jan 2 2017, In : Expert Review of Anticancer Therapy. 17, 1, p. 33-45 13 p.

Research output: Contribution to journalReview article

8 Scopus citations

Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma

Rai, V., Abdo, J., Alsuwaidan, A. N., Agrawal, S., Sharma, P. K. & Agrawal, D. K., Jun 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-24 24 p.

Research output: Contribution to journalArticle

14 Scopus citations

Clinical implications of high-mobility group box-1 (HMGB1) and the receptor for advanced glycation end-products (RAGE) in cutaneous malignancy: A systematic review

Nguyen, A. H., Detty, S. Q. & Agrawal, D. K., Jan 1 2017, In : Anticancer Research. 37, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

Rosenberg, J. H., Rai, V., Dilisio, M. & Agrawal, D. K., May 4 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

ERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells

Almalki, S. G. & Agrawal, D. K., May 12 2017, In : Stem Cell Research and Therapy. 8, 1, 113.

Research output: Contribution to journalArticle

20 Scopus citations

Gene therapy to keep the QT rhythms "on the QT"

Agrawal, D. K. & Boosani, C. S., 2017, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Hormonal therapy in traumatic spinal cord injury

Ludwig, P. E., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 9, p. 3881-3895 15 p., AJTR0057123.

Research output: Contribution to journalReview article

5 Scopus citations

Immunobiology of spinal cord injuries and potential therapeutic approaches

Ahmed, A., Patil, A. A. & Agrawal, D. K., Sep 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

Rosenberg, J. H., Rai, V., Dilisio, M., Sekundiak, T. D. & Agrawal, D. K., Jun 1 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-11 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance

Subramanian, S., Pallati, P. K., Rai, V., Sharma, P. K., Agrawal, D. K. & Nandipati, K. C., Mar 1 2017, In : Obesity. 25, 3, p. 527-538 12 p.

Research output: Contribution to journalArticle

12 Scopus citations