Department of Clinical and Translational Science

Research Output 1987 2020

2020

A systematic review of penetrating extracranial vertebral artery injuries

Asensio, J. A., Dabestani, P. J., Wenzl, F. A., Miljkovic, S. S., Kessler, J. J., Fernandez, C. A., Becker, T., Cornell, D., Siu, M., Voigt, C. & Agrawal, D. K., Jan 1 2020, (Accepted/In press) In : Journal of Vascular Surgery.

Research output: Contribution to journalReview article

Vertebral Artery
Wounds and Injuries
Gunshot Wounds
Incidence
Exsanguination

Infarct Zone: a Novel Platform for Exosome Trade in Cardiac Tissue Regeneration

Thankam, F. G. & Agrawal, D. K., Jan 1 2020, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalReview article

Exosomes
Regeneration
Tissue Engineering
Coronary Artery Disease
Myocardial Infarction
2019
1 Citation (Scopus)
Adipokines
Vascular Diseases
Insulin Resistance
Atherosclerosis
alpha-2-HS-Glycoprotein

An update on PTEN modulators–a patent review

Boosani, C. S., Gunasekar, P. & Agrawal, D. K., Nov 2 2019, In : Expert Opinion on Therapeutic Patents. 29, 11, p. 881-889 9 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Regeneration
Tensins
Bone Regeneration
Immune System Diseases

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition

Satish, M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalReview article

Inflammasomes
Interleukin-1
Anti-Inflammatory Agents
C-Reactive Protein
Interleukin-6

Corrigendum: Discovery of Novel and Clinically Relevant Markers in Formalin-Fixed Paraffin-Embedded Esophageal Cancer Specimen (Front. Oncol (2018) 8 (157) DOI: 10.3389/fonc.2018.00157)

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 273.

Research output: Contribution to journalComment/debate

Open Access
Esophageal Neoplasms
Paraffin
Formaldehyde
Neoplasms
HMGB1 Protein
1 Citation (Scopus)

Epigenetic mechanisms and implications in tendon inflammation (Review)

Thankam, F. G., Boosani, C. S., Dilisio, M. & Agrawal, D. K., Jan 1 2019, In : International Journal of Molecular Medicine. 43, 1, p. 3-14 12 p.

Research output: Contribution to journalReview article

Epigenomics
Tendons
Methyltransferases
DNA Methylation
Inflammation
HMGB1 Protein
Translational Medical Research
HMGB Proteins
Liver
Rage
1 Citation (Scopus)

Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation

Rosenberg, J. H., Werner, J. H., Plitt, G. D., Noble, V. V., Spring, J. T., Stephens, B. A., Siddique, A., Merritt-Genore, H. L., Moulton, M. J. & Agrawal, D. K., Mar 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

Atrial Fibrillation
Biomarkers
Therapeutics
Heat-Shock Proteins
Collagen

Matrix regeneration proteins in the hypoxia-triggered exosomes of shoulder tenocytes and adipose-derived mesenchymal stem cells

Thankam, F. G., Chandra, I., Diaz, C., Dilisio, M. F., Fleegel, J., Gross, R. M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Exosomes
Stem cells
Mesenchymal Stromal Cells
Regeneration
Tendon Injuries

Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine

Gunasekar, P., Satish, M., Dabestani, P., Jiang, W., Boosani, C., Radwan, M., Agrawal, D. K. & Asensio, J. A., Nov 1 2019, In : Journal of Surgical Research. 243, p. 460-468 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Vitamins
Coronary Vessels
Swine
Coronary Balloon Angioplasty
1 Citation (Scopus)

Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia

Thankam, F. G., Palanikumar, G., Fitzgibbons, R. J. & Agrawal, D. K., Apr 1 2019, In : Journal of Surgical Research. 236, p. 134-143 10 p.

Research output: Contribution to journalReview article

Fibroblasts
Collagen
Protein-Lysine 6-Oxidase
Connective Tissue Growth Factor
Phenotype

Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias

Larsen, N. K., Reilly, M. J., Thankam, F. G., Fitzgibbons, R. J. & Agrawal, D. K., Jul 3 2019, In : Expert Review of Clinical Immunology. 15, 7, p. 791-800 10 p.

Research output: Contribution to journalReview article

Extracellular Matrix
Inflammasomes
Collagen Type III
Matrix Metalloproteinase Inhibitors
Expert Testimony
1 Citation (Scopus)

Pro-inflammatory and pro-resolving mechanisms in the immunopathology of arteriovenous fistula maturation

Satish, M., Gunasekar, P. & Agrawal, D. K., May 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 5, p. 369-376 8 p.

Research output: Contribution to journalReview article

Arteriovenous Fistula
Inflammation
Hyperplasia
Expert Testimony
Therapeutics
5 Citations (Scopus)
Hyperplasia
Lipids
Atherosclerosis
Plague
Unsaturated Fatty Acids

Therapeutic potential of exosomes in rotator cuff tendon healing

Connor, D. E., Paulus, J. A., Dabestani, P. J., Thankam, F. K., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2019, In : Journal of Bone and Mineral Metabolism.

Research output: Contribution to journalReview article

Exosomes
Rotator Cuff
Tendons
Aptitude
Collagen
2018
Tendinopathy
Rotator Cuff
Hydrogel
3 Citations (Scopus)

Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury

Thankam, F. G., Chandra, I. S., Kovilam, A. N., Diaz, C. G., Volberding, B. T., Dilisio, M., Radwan, M. M., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 17027.

Research output: Contribution to journalArticle

Tendon Injuries
Tendons
Citrate (si)-Synthase
Swine
Tenotomy
16 Citations (Scopus)

Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon

Thankam, F. G., Roesch, Z. K., Dilisio, M., Radwan, M. M., Kovilam, A., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 8918.

Research output: Contribution to journalArticle

Inflammasomes
HMGB1 Protein
Tendon Injuries
Rotator Cuff
Tendons
10 Citations (Scopus)

Brain injury and neural stem cells

Ludwig, P. E., Thankam, F. G., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., Jan 1 2018, In : Neural Regeneration Research. 13, 1, p. 7-18 12 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Brain Injuries
Stem Cells
Wounds and Injuries
5 Citations (Scopus)

Cell-specific histone modifications in atherosclerosis (Review)

Jiang, W., Agrawal, D. K. & Boosani, C. S., Aug 1 2018, In : Molecular Medicine Reports. 18, 2, p. 1215-1224 10 p.

Research output: Contribution to journalReview article

Histone Code
Histones
Atherosclerosis
Post Translational Protein Processing
Acetylation
2 Citations (Scopus)

Collagen I: A kingpin for rotator cuff tendon pathology

Thankam, F. G., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3291-3309 19 p., AJTR0079000.

Research output: Contribution to journalReview article

Tendinopathy
Rotator Cuff
Tendons
Pathology
Collagen Type I
3 Citations (Scopus)

Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis

Thankam, F. G., Evan, D. K., Agrawal, D. K. & Dilisio, M., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Collagen Type III
Tendons
Arthritis
Collagen
Matrix Metalloproteinases
6 Citations (Scopus)

Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning

Rosenberg, J. H., Werner, J. H., Moulton, M. J. & Agrawal, D. K., May 24 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research. p. 1-16 16 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Reperfusion Injury
Phosphotransferases
Afferent Neurons
Cardiac Myocytes
2 Citations (Scopus)

Delivery of viral vectors for gene therapy in intimal hyperplasia and restenosis in atherosclerotic swine

Hall, S. & Agrawal, D. K., Aug 1 2018, In : Drug Delivery and Translational Research. 8, 4, p. 918-927 10 p.

Research output: Contribution to journalReview article

Tunica Intima
Viral Genes
Genetic Therapy
Hyperplasia
Atherosclerosis

Discovery of novel and clinically relevant markers in formalin-fixed paraffin-embedded esophageal cancer specimen

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., May 9 2018, In : Frontiers in Oncology. 8, MAY, 157.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Paraffin
Formaldehyde
Adenocarcinoma
Biostatistics
1 Citation (Scopus)

FacIle syntheses and molecular-docking of novel substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide/ carbohydrazide Analogues with antimicrobial and antifungal properties

Bhosale, J. D., Dabur, R., Jadhav, G. & Bendre, R. S., Jan 1 2018, In : Molecules. 23, 4, 875.

Research output: Contribution to journalArticle

Pyrroles
pyrroles
Heme
Sterol 14-Demethylase
enzymes
2 Citations (Scopus)

From cord to caudate: Characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain

Maillacheruvu, P. F., Engel, L. M., Crum, I. T., Agrawal, D. K. & Peeples, E. S., Jan 1 2018, In : Pediatric Research. 83, 1-2, p. 205-213 9 p.

Research output: Contribution to journalReview article

Fetal Blood
Blood Cells
Stem Cells
Brain
Stem Cell Transplantation
1 Citation (Scopus)

Genes interconnecting AMPK and TREM-1 and associated microRNAs in rotator cuff tendon injury

Thankam, F. G., Boosani, C. S., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Tendon Injuries
AMP-Activated Protein Kinases
Tendons
MicroRNAs
Genes

Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine

Werner, J. H., Rosenberg, J. H., Keeley, K. L. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Clinical Immunology. 14, 8, p. 695-706 12 p.

Research output: Contribution to journalReview article

Osteolysis
Spine
Inflammation
Pain
Arthroplasty

Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches

Addula, M., Wilson, V. E. D., Reddymasu, S. & Agrawal, D. K., Oct 3 2018, In : Expert Review of Clinical Immunology. 14, 10, p. 831-840 10 p.

Research output: Contribution to journalReview article

Dyspepsia
T-Lymphocytes
Gastric Emptying
Duodenum
Eosinophils
16 Citations (Scopus)

Immunotherapy plus cryotherapy: Potential augmented abscopal effect for advanced cancers

Abdo, J., Cornell, D. L., Mittal, S. K. & Agrawal, D. K., Mar 28 2018, In : Frontiers in Oncology. 8, MAR, 85.

Research output: Contribution to journalReview article

Cryotherapy
Immunotherapy
Immune System
Neoplasms
Cryosurgery

Inhibition of DNA methyltransferase-1 instigates the expression of DNA methyltransferase-3a in angioplasty-induced restenosis

Boosani, C. S., Gunasekar, P., Block, M., Jiang, W., Zhang, Z., Radwan, M. M. & Agrawal, D. K., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 10, p. 1030-1039 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Angioplasty
DNA
Vascular Smooth Muscle
Smooth Muscle Myocytes
7 Citations (Scopus)

Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction

Plitt, G. D., Spring, J. T., Moulton, M. J. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Cardiovascular Therapy. 16, 8, p. 579-589 11 p.

Research output: Contribution to journalReview article

Treatment Failure
Heart Failure
Diastolic Heart Failure
Delayed Diagnosis
Therapeutics
2 Citations (Scopus)

Molecular discoveries and treatment strategies by direct reprogramming in cardiac regeneration

Werner, J. H., Rosenberg, J. H., Um, J. Y., Moulton, M. J. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cardiac Myocytes
Regeneration
Fibroblasts
Tissue
MicroRNAs
7 Citations (Scopus)

Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to Clinical Translation

Karagiannis, A. D., Liu, M., Toth, P. P., Zhao, S., Agrawal, D. K., Libby, P. & Chatzizisis, Y. S., Apr 1 2018, In : Current Atherosclerosis Reports. 20, 4, 20.

Research output: Contribution to journalReview article

Molecular Biology
Atherosclerosis
Atherosclerotic Plaques
Smooth Muscle Myocytes
Endothelial Cells

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma

Singhal, S., Kapoor, H., Subramanian, S., Agrawal, D. K. & Mittal, S. K., Jan 1 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Vitamin D
Adenocarcinoma
Calcitriol Receptors
Barrett Esophagus
Genes
1 Citation (Scopus)

Rejuvenation of “broken heart” with bioengineered gel

Agrawal, D. K. & Siddique, A., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Rejuvenation
Gels
1 Citation (Scopus)

Vitamin D and macrophage polarization in epicardial adipose tissue of atherosclerotic swine

Gunasekar, P., Swier, V. J., Fleegel, J. P., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Oct 1 2018, In : PLoS One. 13, 10, e0199411.

Research output: Contribution to journalArticle

Macrophages
vitamin D
Vitamin D
adipose tissue
Adipose Tissue
2017
7 Citations (Scopus)

Alterations in tendon microenvironment in response to mechanical load: Potential molecular targets for treatment strategies

Fouda, M. B., Thankam, F. G., Dilisio, M. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 10, p. 4341-4360 20 p., AJTR0059913.

Research output: Contribution to journalReview article

Tendons
Rotator Cuff
Therapeutics
Pain
Tendinopathy
8 Citations (Scopus)

Basis for molecular diagnostics and immunotherapy for esophageal cancer

Abdo, J., Agrawal, D. K. & Mittal, S. K., Jan 2 2017, In : Expert Review of Anticancer Therapy. 17, 1, p. 33-45 13 p.

Research output: Contribution to journalReview article

Molecular Pathology
Esophageal Neoplasms
Immunotherapy
Platinum
Survival
14 Citations (Scopus)

Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma

Rai, V., Abdo, J., Alsuwaidan, A. N., Agrawal, S., Sharma, P. K. & Agrawal, D. K., Jun 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-24 24 p.

Research output: Contribution to journalArticle

T-cells
Liver
Immunotherapy
Hepatocellular Carcinoma
Cytokine Receptors
18 Citations (Scopus)
Melanoma
Skin
Basal Cell Carcinoma
Squamous Cell Carcinoma
Neoplasms
18 Citations (Scopus)

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

Rosenberg, J. H., Rai, V., Dilisio, M. & Agrawal, D. K., May 4 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

Osteoarthritis
Cartilage
Heparitin Sulfate
Toll-Like Receptors
Cytokines
19 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Stem cells
Matrix Metalloproteinases
Mesenchymal Stromal Cells
Myeloid Cells
Insulin Resistance
Obesity
Population
Morbid Obesity

Gene therapy to keep the QT rhythms "on the QT"

Agrawal, D. K. & Boosani, C. S., 2017, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Genetic Therapy
4 Citations (Scopus)

Hormonal therapy in traumatic spinal cord injury

Ludwig, P. E., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 9, p. 3881-3895 15 p., AJTR0057123.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Chorionic Gonadotropin
Progesterone
Spinal Cord
Estrogens
8 Citations (Scopus)

Immunobiology of spinal cord injuries and potential therapeutic approaches

Ahmed, A., Patil, A. A. & Agrawal, D. K., Sep 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Wounds and Injuries
Macrophages
Astrocytes
Therapeutics
8 Citations (Scopus)

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

Rosenberg, J. H., Rai, V., Dilisio, M., Sekundiak, T. D. & Agrawal, D. K., Jun 1 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-11 11 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Hip Joint
Cartilage
Knee Joint
Osteoarthritis