Department of Clinical and Translational Science

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2019

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg 2+ -dependent binding

Airhihen, B., Pavanello, L., Jadhav, G. P., Fischer, P. M. & Winkler, G. S., Apr 1 2019, In : FEBS Open Bio. 9, 4, p. 717-727 11 p.

Research output: Contribution to journalArticle

Open Access

Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine

Gunasekar, P., Satish, M., Dabestani, P., Jiang, W., Boosani, C., Radwan, M., Agrawal, D. K. & Asensio, J. A., Nov 1 2019, In : Journal of Surgical Research. 243, p. 460-468 9 p.

Research output: Contribution to journalArticle

Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases

Satish, M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Expert Review of Cardiovascular Therapy.

Research output: Contribution to journalArticle

5 Scopus citations
2018

All in one hydrogel approach: A translationally-worthwhile scenario for rotator cuff tendinopathies

Thankam, F. G., Dilisio, M. & Agrawal, D. K., Jul 25 2018, In : Trends in Biomaterials and Artificial Organs. 32, 1, p. 46-48 3 p.

Research output: Contribution to journalArticle

Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury

Thankam, F. G., Chandra, I. S., Kovilam, A. N., Diaz, C. G., Volberding, B. T., Dilisio, M., Radwan, M. M., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 17027.

Research output: Contribution to journalArticle

3 Scopus citations

Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon

Thankam, F. G., Roesch, Z. K., Dilisio, M., Radwan, M. M., Kovilam, A., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 8918.

Research output: Contribution to journalArticle

18 Scopus citations

Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis

Thankam, F. G., Evan, D. K., Agrawal, D. K. & Dilisio, M., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning

Rosenberg, J. H., Werner, J. H., Moulton, M. J. & Agrawal, D. K., May 24 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research. p. 1-16 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of novel and clinically relevant markers in formalin-fixed paraffin-embedded esophageal cancer specimen

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., May 9 2018, In : Frontiers in Oncology. 8, MAY, 157.

Research output: Contribution to journalArticle

FacIle syntheses and molecular-docking of novel substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide/ carbohydrazide Analogues with antimicrobial and antifungal properties

Bhosale, J. D., Dabur, R., Jadhav, G. & Bendre, R. S., Jan 1 2018, In : Molecules. 23, 4, 875.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of DNA methyltransferase-1 instigates the expression of DNA methyltransferase-3a in angioplasty-induced restenosis

Boosani, C. S., Gunasekar, P., Block, M., Jiang, W., Zhang, Z., Radwan, M. M. & Agrawal, D. K., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 10, p. 1030-1039 10 p.

Research output: Contribution to journalArticle

Molecular discoveries and treatment strategies by direct reprogramming in cardiac regeneration

Werner, J. H., Rosenberg, J. H., Um, J. Y., Moulton, M. J. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

3 Scopus citations

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma

Singhal, S., Kapoor, H., Subramanian, S., Agrawal, D. K. & Mittal, S. K., Jan 1 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Rejuvenation of “broken heart” with bioengineered gel

Agrawal, D. K. & Siddique, A., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Vitamin D and macrophage polarization in epicardial adipose tissue of atherosclerotic swine

Gunasekar, P., Swier, V. J., Fleegel, J. P., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Oct 1 2018, In : PLoS One. 13, 10, e0199411.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma

Rai, V., Abdo, J., Alsuwaidan, A. N., Agrawal, S., Sharma, P. K. & Agrawal, D. K., Jun 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-24 24 p.

Research output: Contribution to journalArticle

17 Scopus citations

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

Rosenberg, J. H., Rai, V., Dilisio, M. & Agrawal, D. K., May 4 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

ERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells

Almalki, S. G. & Agrawal, D. K., May 12 2017, In : Stem Cell Research and Therapy. 8, 1, 113.

Research output: Contribution to journalArticle

20 Scopus citations

Gene therapy to keep the QT rhythms "on the QT"

Agrawal, D. K. & Boosani, C. S., 2017, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Immunobiology of spinal cord injuries and potential therapeutic approaches

Ahmed, A., Patil, A. A. & Agrawal, D. K., Sep 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

Rosenberg, J. H., Rai, V., Dilisio, M., Sekundiak, T. D. & Agrawal, D. K., Jun 1 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-11 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance

Subramanian, S., Pallati, P. K., Rai, V., Sharma, P. K., Agrawal, D. K. & Nandipati, K. C., Mar 1 2017, In : Obesity. 25, 3, p. 527-538 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation

Hall, S. C. & Agrawal, D. K., Dec 1 2017, In : Scientific Reports. 7, 1, 11853.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis

Thankam, F. G., Boosani, C. S., Dilisio, M. & Agrawal, D. K., Jun 20 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-17 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells

Almalki, S. G., Valle, Y. L. & Agrawal, D. K., May 1 2017, In : Stem cells translational medicine. 6, 5, p. 1385-1398 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neoadjuvant therapy for esophageal adenocarcinoma in the community setting-practice and outcomes

Abdo, J., Bertellotti, C. A., Cornell, D. L., Agrawal, D. K. & Mittal, S. K., Jul 18 2017, In : Frontiers in Oncology. 7, JUL, 151.

Research output: Contribution to journalArticle

2 Scopus citations

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

Baker, J. G., Gardiner, S. M., Woolard, J., Fromont, C., Jadhav, G. P., Mistry, S. N., Thompson, K. S. J., Kellam, B., Hill, S. J. & Fischer, P. M., Jul 2017, In : FASEB Journal. 31, 7, p. 3150-3166 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Recent strategies in cartilage repair: A systemic review of the scaffold development and tissue engineering

Rai, V., Dilisio, M., Dietz, N. E. & Agrawal, D. K., 2017, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

49 Scopus citations

Significant association of TREM-1 with HMGB1, TLRs and RAGE in the pathogenesis of insulin resistance in obese diabetic populations

Subramanian, S., Pallati, P. K., Sharma, P. K., Agrawal, D. K. & Nandipati, K. C., 2017, In : American Journal of Translational Research. 9, 7, p. 3224-3244 21 p.

Research output: Contribution to journalArticle

12 Scopus citations

"Targeted" chemotherapy for esophageal cancer

Abdo, J., Agrawal, D. K. & Mittal, S. K., Apr 3 2017, In : Frontiers in Oncology. 7, APR, 63.

Research output: Contribution to journalArticle

6 Scopus citations

Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review

Agarwal, S., Kovilam, O. & Agrawal, D. K., Jun 15 2017, (Accepted/In press) In : Critical Reviews in Food Science and Nutrition. p. 1-15 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Cellular reprogramming in cardiac diseases: A feather in the hat of regenerative medicine

Agrawal, D. K. & Boosani, C. S., 2016, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Cutaneous expression of TREM, vitamin D receptor and HMGB1 in vitamin D deficiency

Nguyen, A. H., Lim, V. M., Fleegel, J. P., Hunter, W. J. & Agrawal, D. K., 2016, In : International Journal of Clinical and Experimental Pathology. 9, 8, p. 8506-8512 7 p.

Research output: Contribution to journalArticle

Data on TREM-1 activation destabilizing carotid plaques

Rao, V. H., Rai, V., Stoupa, S., Subramanian, S. & Agrawal, D. K., Sep 1 2016, In : Data in Brief. 8, p. 230-234 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis

Rai, V., Rao, V. H., Shao, Z. & Agrawal, D. K., 2016, In : PLoS One. 11, 5, p. e0154802

Research output: Contribution to journalArticle

12 Scopus citations

Differentiation of porcine mesenchymal stem cells into epithelial cells as a potential therapeutic application to facilitate epithelial regeneration

Kokubun, K., Pankajakshan, D., Kim, M. J. & Agrawal, D. K., Feb 1 2016, In : Journal of Tissue Engineering and Regenerative Medicine. 10, 2, p. E73-E83

Research output: Contribution to journalArticle

12 Scopus citations

FOXO1 mediates Vitamin D deficiency-induced insulin resistance in skeletal muscle

Chen, S., Villalta, S. A. & Agrawal, D. K., Mar 1 2016, In : Journal of Bone and Mineral Research. 31, 3, p. 585-595 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Increased expression of phosphorylated polo- like kinase 1 and histone in bypass vein graft and coronary arteries following angioplasty

Sur, S., Swier, V. J., Radwan, M. M. & Agrawal, D. K., Jan 1 2016, In : PLoS One. 11, 1, e0147937.

Research output: Contribution to journalArticle

3 Scopus citations

MicroRNas associated with shoulder tendon matrisome disorganization in glenohumeral arthritis

Thankam, F. G., Boosani, C. S., Dilisio, M., Dietz, N. E. & Agrawal, D. K., Dec 1 2016, In : PLoS One. 11, 12, e0168077.

Research output: Contribution to journalArticle

14 Scopus citations

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S. & Agrawal, D. K., Nov 21 2016, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-19 19 p.

Research output: Contribution to journalArticle

41 Scopus citations

The role of high cholesterol-high fructose diet on coronary arteriosclerosis

Swier, V. J., Tang, L., Radwan, M. M., Hunter, W. J. & Agrawal, D. K., Feb 1 2016, In : Histology and Histopathology. 31, 2, p. 167-176 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Traumatic pulmonary pseudocyst: An underreported entity

Phillips, B., Shaw, J., Turco, L., McDonald, D., Carey, J., Balters, M., Wagner, M., Bertellotti, R., Cornell, D. L., Agrawal, D. K. & Asensio, J. A., Dec 6 2016, (Accepted/In press) In : Injury.

Research output: Contribution to journalArticle

6 Scopus citations

TREM-1, HMGB1 and RAGE in the shoulder tendon: Dual mechanisms for inflammation based on the coincidence of glenohumeral arthritis

Thankam, F. G., Dilisio, M., Dietz, N. E. & Agrawal, D. K., Oct 1 2016, In : PLoS One. 11, 10, e0165492.

Research output: Contribution to journalArticle

26 Scopus citations

Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis

Rao, V. H., Rai, V., Stoupa, S., Subramanian, S. & Agrawal, D. K., May 1 2016, In : Atherosclerosis. 248, p. 160-169 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine

Rai, V., Dietz, N. E., Dilisio, M., Radwan, M. M. & Agrawal, D. K., Sep 13 2016, In : Arthritis Research and Therapy. 18, 1, 203.

Research output: Contribution to journalArticle

7 Scopus citations

Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation

Pelham, C. J., Drews, E. M. & Agrawal, D. K., Sep 1 2016, In : Journal of Molecular and Cellular Cardiology. 98, p. 1-10 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine

Chen, S., Swier, V. J., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Aug 1 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 8, p. 1651-1659 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells

Valle, Y. L., Almalki, S. G. & Agrawal, D. K., Aug 17 2016, In : Stem Cell Research and Therapy. 7, 1, 118.

Research output: Contribution to journalArticle

8 Scopus citations

Vitamin D Supplementation Reduces Induction of Epithelial-Mesenchymal Transition in Allergen Sensitized and Challenged Mice

Fischer, K. D., Hall, S. C. & Agrawal, D. K., Feb 1 2016, In : PLoS One. 11, 2, e0149180.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells

Ikhapoh, I. A., Pelham, C. J. & Agrawal, D. K., 2015, In : Stem Cells International. 2015, 498328.

Research output: Contribution to journalArticle

14 Scopus citations