Department of Clinical and Translational Science

Research Output 1987 2019

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2019

Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine

Gunasekar, P., Satish, M., Dabestani, P., Jiang, W., Boosani, C., Radwan, M., Agrawal, D. K. & Asensio, J. A., Nov 1 2019, In : Journal of Surgical Research. 243, p. 460-468 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Vitamins
Coronary Vessels
Swine
Coronary Balloon Angioplasty
Hyperplasia
Lipids
Atherosclerosis
Plague
Unsaturated Fatty Acids
2018
Tendinopathy
Rotator Cuff
Hydrogel
1 Citation (Scopus)

Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury

Thankam, F. G., Chandra, I. S., Kovilam, A. N., Diaz, C. G., Volberding, B. T., Dilisio, M., Radwan, M. M., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 17027.

Research output: Contribution to journalArticle

Tendon Injuries
Tendons
Citrate (si)-Synthase
Swine
Tenotomy
5 Citations (Scopus)

Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon

Thankam, F. G., Roesch, Z. K., Dilisio, M., Radwan, M. M., Kovilam, A., Gross, R. M. & Agrawal, D. K., Dec 1 2018, In : Scientific Reports. 8, 1, 8918.

Research output: Contribution to journalArticle

Inflammasomes
HMGB1 Protein
Tendon Injuries
Rotator Cuff
Tendons
1 Citation (Scopus)

Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis

Thankam, F. G., Evan, D. K., Agrawal, D. K. & Dilisio, M., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Collagen Type III
Tendons
Arthritis
Collagen
Matrix Metalloproteinases
2 Citations (Scopus)

Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning

Rosenberg, J. H., Werner, J. H., Moulton, M. J. & Agrawal, D. K., May 24 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research. p. 1-16 16 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Reperfusion Injury
Phosphotransferases
Afferent Neurons
Cardiac Myocytes

Discovery of novel and clinically relevant markers in formalin-fixed paraffin-embedded esophageal cancer specimen

Abdo, J., Wichman, C. S., Dietz, N. E., Ciborowski, P., Fleegel, J., Mittal, S. K. & Agrawal, D. K., May 9 2018, In : Frontiers in Oncology. 8, MAY, 157.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Paraffin
Formaldehyde
Adenocarcinoma
Biostatistics
1 Citation (Scopus)

FacIle syntheses and molecular-docking of novel substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide/ carbohydrazide Analogues with antimicrobial and antifungal properties

Bhosale, J. D., Dabur, R., Jadhav, G. & Bendre, R. S., Jan 1 2018, In : Molecules. 23, 4, 875.

Research output: Contribution to journalArticle

Pyrroles
pyrroles
Heme
Sterol 14-Demethylase
enzymes

Genes interconnecting AMPK and TREM-1 and associated microRNAs in rotator cuff tendon injury

Thankam, F. G., Boosani, C. S., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticle

Tendon Injuries
AMP-Activated Protein Kinases
Tendons
MicroRNAs
Genes

Inhibition of DNA methyltransferase-1 instigates the expression of DNA methyltransferase-3a in angioplasty-induced restenosis

Boosani, C. S., Gunasekar, P., Block, M., Jiang, W., Zhang, Z., Radwan, M. M. & Agrawal, D. K., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 10, p. 1030-1039 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Angioplasty
DNA
Vascular Smooth Muscle
Smooth Muscle Myocytes
1 Citation (Scopus)

Molecular discoveries and treatment strategies by direct reprogramming in cardiac regeneration

Werner, J. H., Rosenberg, J. H., Um, J. Y., Moulton, M. J. & Agrawal, D. K., Jan 1 2018, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cardiac Myocytes
Regeneration
Fibroblasts
Tissue
MicroRNAs

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma

Singhal, S., Kapoor, H., Subramanian, S., Agrawal, D. K. & Mittal, S. K., Jan 1 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Vitamin D
Adenocarcinoma
Calcitriol Receptors
Barrett Esophagus
Genes
1 Citation (Scopus)

Rejuvenation of “broken heart” with bioengineered gel

Agrawal, D. K. & Siddique, A., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Rejuvenation
Gels
1 Citation (Scopus)

Vitamin D and macrophage polarization in epicardial adipose tissue of atherosclerotic swine

Gunasekar, P., Swier, V. J., Fleegel, J. P., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Oct 1 2018, In : PLoS One. 13, 10, e0199411.

Research output: Contribution to journalArticle

Macrophages
vitamin D
Vitamin D
adipose tissue
Adipose Tissue
2017
11 Citations (Scopus)

Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma

Rai, V., Abdo, J., Alsuwaidan, A. N., Agrawal, S., Sharma, P. K. & Agrawal, D. K., Jun 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-24 24 p.

Research output: Contribution to journalArticle

T-cells
Liver
Immunotherapy
Hepatocellular Carcinoma
Cytokine Receptors
15 Citations (Scopus)

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

Rosenberg, J. H., Rai, V., Dilisio, M. & Agrawal, D. K., May 4 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

Osteoarthritis
Cartilage
Heparitin Sulfate
Toll-Like Receptors
Cytokines
11 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Stem cells
Matrix Metalloproteinases
Mesenchymal Stromal Cells

Gene therapy to keep the QT rhythms "on the QT"

Agrawal, D. K. & Boosani, C. S., 2017, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Genetic Therapy
3 Citations (Scopus)

Immunobiology of spinal cord injuries and potential therapeutic approaches

Ahmed, A., Patil, A. A. & Agrawal, D. K., Sep 7 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-9 9 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Wounds and Injuries
Macrophages
Astrocytes
Therapeutics
6 Citations (Scopus)

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

Rosenberg, J. H., Rai, V., Dilisio, M., Sekundiak, T. D. & Agrawal, D. K., Jun 1 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-11 11 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Hip Joint
Cartilage
Knee Joint
Osteoarthritis
12 Citations (Scopus)

Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance

Subramanian, S., Pallati, P. K., Rai, V., Sharma, P. K., Agrawal, D. K. & Nandipati, K. C., Mar 1 2017, In : Obesity. 25, 3, p. 527-538 12 p.

Research output: Contribution to journalArticle

Myeloid Cells
Insulin Resistance
Obesity
Population
Biopsy
1 Citation (Scopus)
Myeloid Cells
Dendritic Cells
Lymph Nodes
Inflammation
Lung
6 Citations (Scopus)

MicroRNAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis

Thankam, F. G., Boosani, C. S., Dilisio, M. & Agrawal, D. K., Jun 20 2017, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-17 17 p.

Research output: Contribution to journalArticle

Tendinopathy
MicroRNAs
Arthritis
Genes
Inflammation
6 Citations (Scopus)
Matrix Metalloproteinase 14
Vascular Endothelial Growth Factor Receptor-2
Matrix Metalloproteinase 2
Mesenchymal Stromal Cells
Swine
2 Citations (Scopus)

Neoadjuvant therapy for esophageal adenocarcinoma in the community setting-practice and outcomes

Abdo, J., Bertellotti, C. A., Cornell, D. L., Agrawal, D. K. & Mittal, S. K., Jul 18 2017, In : Frontiers in Oncology. 7, JUL, 151.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Esophageal Neoplasms
Adenocarcinoma
Pharmaceutical Preparations
Molecular Diagnostic Techniques
31 Citations (Scopus)
Cartilage
Scaffolds (biology)
Tissue engineering
Repair
Scaffolds
5 Citations (Scopus)
HMGB1 Protein
Toll-Like Receptors
Myeloid Cells
Insulin Resistance
Insulin
6 Citations (Scopus)

"Targeted" chemotherapy for esophageal cancer

Abdo, J., Agrawal, D. K. & Mittal, S. K., Apr 3 2017, In : Frontiers in Oncology. 7, APR, 63.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Drug Therapy
Immunotherapy
Survival
Survival Rate
9 Citations (Scopus)
Macrophages
Biopsy
Insulin Resistance
Liver
Insulin
5 Citations (Scopus)

Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review

Agarwal, S., Kovilam, O. & Agrawal, D. K., Jun 15 2017, (Accepted/In press) In : Critical Reviews in Food Science and Nutrition. p. 1-15 15 p.

Research output: Contribution to journalArticle

pregnancy outcome
Vitamins
Pregnancy Outcome
vitamin D
Vitamin D
2016
1 Citation (Scopus)

Cellular reprogramming in cardiac diseases: A feather in the hat of regenerative medicine

Agrawal, D. K. & Boosani, C. S., 2016, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Feathers
Regenerative Medicine
Heart Diseases
Cellular Reprogramming

Cutaneous expression of TREM, vitamin D receptor and HMGB1 in vitamin D deficiency

Nguyen, A. H., Lim, V. M., Fleegel, J. P., Hunter, W. J. & Agrawal, D. K., 2016, In : International Journal of Clinical and Experimental Pathology. 9, 8, p. 8506-8512 7 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Calcitriol Receptors
Vitamin D Deficiency
Myeloid Cells
Skin
3 Citations (Scopus)

Data on TREM-1 activation destabilizing carotid plaques

Rao, V. H., Rai, V., Stoupa, S., Subramanian, S. & Agrawal, D. K., Sep 1 2016, In : Data in Brief. 8, p. 230-234 5 p.

Research output: Contribution to journalArticle

activation
interpretation
10 Citations (Scopus)
Carotid Stenosis
Myeloid Cells
dendritic cells
Dendritic Cells
receptors
8 Citations (Scopus)
Stem cells
Mesenchymal Stromal Cells
Regeneration
Swine
Epithelial Cells
18 Citations (Scopus)

FOXO1 mediates Vitamin D deficiency-induced insulin resistance in skeletal muscle

Chen, S., Villalta, S. A. & Agrawal, D. K., Mar 1 2016, In : Journal of Bone and Mineral Research. 31, 3, p. 585-595 11 p.

Research output: Contribution to journalArticle

Vitamin D Deficiency
Insulin Resistance
Calcitriol Receptors
Skeletal Muscle
Vitamin D
1 Citation (Scopus)

Increased expression of phosphorylated polo- like kinase 1 and histone in bypass vein graft and coronary arteries following angioplasty

Sur, S., Swier, V. J., Radwan, M. M. & Agrawal, D. K., Jan 1 2016, In : PLoS One. 11, 1, e0147937.

Research output: Contribution to journalArticle

coronary vessels
Coronary Balloon Angioplasty
Angioplasty
blood vessels
histones
10 Citations (Scopus)

MicroRNas associated with shoulder tendon matrisome disorganization in glenohumeral arthritis

Thankam, F. G., Boosani, C. S., Dilisio, M., Dietz, N. E. & Agrawal, D. K., Dec 1 2016, In : PLoS One. 11, 12, e0168077.

Research output: Contribution to journalArticle

Tendons
arthritis
tendons
MicroRNAs
shoulders
25 Citations (Scopus)

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S. & Agrawal, D. K., Nov 21 2016, (Accepted/In press) In : Molecular and Cellular Biochemistry. p. 1-19 19 p.

Research output: Contribution to journalArticle

Protein Kinases
Insulin Resistance
Phosphotransferases
Obesity
Insulin Receptor
3 Citations (Scopus)

The role of high cholesterol-high fructose diet on coronary arteriosclerosis

Swier, V. J., Tang, L., Radwan, M. M., Hunter, W. J. & Agrawal, D. K., Feb 1 2016, In : Histology and Histopathology. 31, 2, p. 167-176 10 p.

Research output: Contribution to journalArticle

Fructose
Coronary Artery Disease
Cholesterol
Diet
Swine
4 Citations (Scopus)

Traumatic pulmonary pseudocyst: An underreported entity

Phillips, B., Shaw, J., Turco, L., McDonald, D., Carey, J., Balters, M., Wagner, M., Bertellotti, R., Cornell, D. L., Agrawal, D. K. & Asensio, J. A., Dec 6 2016, (Accepted/In press) In : Injury.

Research output: Contribution to journalArticle

Lung
Wounds and Injuries
Thorax
Unnecessary Procedures
Medical Errors
17 Citations (Scopus)

TREM-1, HMGB1 and RAGE in the shoulder tendon: Dual mechanisms for inflammation based on the coincidence of glenohumeral arthritis

Thankam, F. G., Dilisio, M., Dietz, N. E. & Agrawal, D. K., Oct 1 2016, In : PLoS One. 11, 10, e0165492.

Research output: Contribution to journalArticle

HMGB Proteins
HMGB1 Protein
Tendons
arthritis
Myeloid Cells
17 Citations (Scopus)
Matrix Metalloproteinase 1
Carotid Stenosis
Myeloid Cells
Matrix Metalloproteinases
Tumor Necrosis Factor-alpha
6 Citations (Scopus)

Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine

Rai, V., Dietz, N. E., Dilisio, M., Radwan, M. M. & Agrawal, D. K., Sep 13 2016, In : Arthritis Research and Therapy. 18, 1, 203.

Research output: Contribution to journalArticle

Vitamin D
Cartilage
Knee
Inflammation
Knee Joint
10 Citations (Scopus)
Vitamin D
Adipose Tissue
Arteries
Inflammation
Vitamin D Deficiency
7 Citations (Scopus)

Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine

Chen, S., Swier, V. J., Boosani, C. S., Radwan, M. M. & Agrawal, D. K., Aug 1 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 8, p. 1651-1659 9 p.

Research output: Contribution to journalArticle

Vitamin D Deficiency
Disease Progression
Coronary Artery Disease
Swine
Adipose Tissue
6 Citations (Scopus)

Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells

Valle, Y. L., Almalki, S. G. & Agrawal, D. K., Aug 17 2016, In : Stem Cell Research and Therapy. 7, 1, 118.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Metabolism
Vitamin D
Machinery
15 Citations (Scopus)

Vitamin D Supplementation Reduces Induction of Epithelial-Mesenchymal Transition in Allergen Sensitized and Challenged Mice

Fischer, K. D., Hall, S. C. & Agrawal, D. K., Feb 1 2016, In : PLoS One. 11, 2, e0149180.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
vitamin D
allergens
Vitamin D
Allergens
7 Citations (Scopus)

Vitamin D supplementation reduces intimal hyperplasia and restenosis following coronary intervention in atherosclerotic swine

Gupta, G. K., Agrawal, T., Rai, V., Del Core, M., Hunter, W. J. & Agrawal, D. K., Jun 1 2016, In : PLoS One. 11, 6, e0156857.

Research output: Contribution to journalArticle

Coronary Restenosis
Tunica Intima
vitamin D
hyperplasia
Vitamin D