Department of Clinical and Translational Science

Research Output 1987 2019

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Review article
2019
Adipokines
Vascular Diseases
Insulin Resistance
Atherosclerosis
alpha-2-HS-Glycoprotein

An update on PTEN modulators–a patent review

Boosani, C. S., Gunasekar, P. & Agrawal, D. K., Nov 2 2019, In : Expert Opinion on Therapeutic Patents. 29, 11, p. 881-889 9 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Regeneration
Tensins
Bone Regeneration
Immune System Diseases

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition

Satish, M. & Agrawal, D. K., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalReview article

Inflammasomes
Interleukin-1
Anti-Inflammatory Agents
C-Reactive Protein
Interleukin-6

Epigenetic mechanisms and implications in tendon inflammation (Review)

Thankam, F. G., Boosani, C. S., Dilisio, M. & Agrawal, D. K., Jan 1 2019, In : International Journal of Molecular Medicine. 43, 1, p. 3-14 12 p.

Research output: Contribution to journalReview article

Epigenomics
Tendons
Methyltransferases
DNA Methylation
Inflammation

Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation

Rosenberg, J. H., Werner, J. H., Plitt, G. D., Noble, V. V., Spring, J. T., Stephens, B. A., Siddique, A., Merritt-Genore, H. L., Moulton, M. J. & Agrawal, D. K., Mar 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

Atrial Fibrillation
Biomarkers
Therapeutics
Heat-Shock Proteins
Collagen

Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia

Thankam, F. G., Palanikumar, G., Fitzgibbons, R. J. & Agrawal, D. K., Apr 1 2019, In : Journal of Surgical Research. 236, p. 134-143 10 p.

Research output: Contribution to journalReview article

Fibroblasts
Collagen
Protein-Lysine 6-Oxidase
Connective Tissue Growth Factor
Phenotype

Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias

Larsen, N. K., Reilly, M. J., Thankam, F. G., Fitzgibbons, R. J. & Agrawal, D. K., Jul 3 2019, In : Expert Review of Clinical Immunology. 15, 7, p. 791-800 10 p.

Research output: Contribution to journalReview article

Extracellular Matrix
Inflammasomes
Collagen Type III
Matrix Metalloproteinase Inhibitors
Expert Testimony

Pro-inflammatory and pro-resolving mechanisms in the immunopathology of arteriovenous fistula maturation

Satish, M., Gunasekar, P. & Agrawal, D. K., May 4 2019, In : Expert Review of Cardiovascular Therapy. 17, 5, p. 369-376 8 p.

Research output: Contribution to journalReview article

Arteriovenous Fistula
Inflammation
Hyperplasia
Expert Testimony
Therapeutics

Therapeutic potential of exosomes in rotator cuff tendon healing

Connor, D. E., Paulus, J. A., Dabestani, P. J., Thankam, F. K., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2019, In : Journal of Bone and Mineral Metabolism.

Research output: Contribution to journalReview article

Exosomes
Rotator Cuff
Tendons
Aptitude
Collagen
2018
8 Citations (Scopus)

Brain injury and neural stem cells

Ludwig, P. E., Thankam, F. G., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., Jan 1 2018, In : Neural Regeneration Research. 13, 1, p. 7-18 12 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Brain Injuries
Stem Cells
Wounds and Injuries
3 Citations (Scopus)

Cell-specific histone modifications in atherosclerosis (Review)

Jiang, W., Agrawal, D. K. & Boosani, C. S., Aug 1 2018, In : Molecular Medicine Reports. 18, 2, p. 1215-1224 10 p.

Research output: Contribution to journalReview article

Histone Code
Histones
Atherosclerosis
Post Translational Protein Processing
Acetylation
1 Citation (Scopus)

Collagen I: A kingpin for rotator cuff tendon pathology

Thankam, F. G., Dilisio, M., Gross, R. M. & Agrawal, D. K., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3291-3309 19 p., AJTR0079000.

Research output: Contribution to journalReview article

Tendinopathy
Rotator Cuff
Tendons
Pathology
Collagen Type I
2 Citations (Scopus)

Delivery of viral vectors for gene therapy in intimal hyperplasia and restenosis in atherosclerotic swine

Hall, S. & Agrawal, D. K., Aug 1 2018, In : Drug Delivery and Translational Research. 8, 4, p. 918-927 10 p.

Research output: Contribution to journalReview article

Tunica Intima
Viral Genes
Genetic Therapy
Hyperplasia
Atherosclerosis
1 Citation (Scopus)

From cord to caudate: Characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain

Maillacheruvu, P. F., Engel, L. M., Crum, I. T., Agrawal, D. K. & Peeples, E. S., Jan 1 2018, In : Pediatric Research. 83, 1-2, p. 205-213 9 p.

Research output: Contribution to journalReview article

Fetal Blood
Blood Cells
Stem Cells
Brain
Stem Cell Transplantation

Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine

Werner, J. H., Rosenberg, J. H., Keeley, K. L. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Clinical Immunology. 14, 8, p. 695-706 12 p.

Research output: Contribution to journalReview article

Osteolysis
Spine
Inflammation
Pain
Arthroplasty

Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches

Addula, M., Wilson, V. E. D., Reddymasu, S. & Agrawal, D. K., Oct 3 2018, In : Expert Review of Clinical Immunology. 14, 10, p. 831-840 10 p.

Research output: Contribution to journalReview article

Dyspepsia
T-Lymphocytes
Gastric Emptying
Duodenum
Eosinophils
4 Citations (Scopus)

Immunotherapy plus cryotherapy: Potential augmented abscopal effect for advanced cancers

Abdo, J., Cornell, D. L., Mittal, S. K. & Agrawal, D. K., Mar 28 2018, In : Frontiers in Oncology. 8, MAR, 85.

Research output: Contribution to journalReview article

Cryotherapy
Immunotherapy
Immune System
Neoplasms
Cryosurgery
3 Citations (Scopus)

Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction

Plitt, G. D., Spring, J. T., Moulton, M. J. & Agrawal, D. K., Aug 3 2018, In : Expert Review of Cardiovascular Therapy. 16, 8, p. 579-589 11 p.

Research output: Contribution to journalReview article

Treatment Failure
Heart Failure
Diastolic Heart Failure
Delayed Diagnosis
Therapeutics
6 Citations (Scopus)

Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to Clinical Translation

Karagiannis, A. D., Liu, M., Toth, P. P., Zhao, S., Agrawal, D. K., Libby, P. & Chatzizisis, Y. S., Apr 1 2018, In : Current Atherosclerosis Reports. 20, 4, 20.

Research output: Contribution to journalReview article

Molecular Biology
Atherosclerosis
Atherosclerotic Plaques
Smooth Muscle Myocytes
Endothelial Cells
2017
5 Citations (Scopus)

Alterations in tendon microenvironment in response to mechanical load: Potential molecular targets for treatment strategies

Fouda, M. B., Thankam, F. G., Dilisio, M. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 10, p. 4341-4360 20 p., AJTR0059913.

Research output: Contribution to journalReview article

Tendons
Rotator Cuff
Therapeutics
Pain
Tendinopathy
6 Citations (Scopus)

Basis for molecular diagnostics and immunotherapy for esophageal cancer

Abdo, J., Agrawal, D. K. & Mittal, S. K., Jan 2 2017, In : Expert Review of Anticancer Therapy. 17, 1, p. 33-45 13 p.

Research output: Contribution to journalReview article

Molecular Pathology
Esophageal Neoplasms
Immunotherapy
Platinum
Survival
17 Citations (Scopus)
Melanoma
Skin
Basal Cell Carcinoma
Squamous Cell Carcinoma
Neoplasms
4 Citations (Scopus)

Hormonal therapy in traumatic spinal cord injury

Ludwig, P. E., Patil, A. A., Chamczuk, A. J. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 9, p. 3881-3895 15 p., AJTR0057123.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Chorionic Gonadotropin
Progesterone
Spinal Cord
Estrogens
1 Citation (Scopus)

Interplay of immunity and vitamin D: Interactions and implications with current IBD therapy

Abdo, J., Rai, V. & Agrawal, D. K., 2017, In : Current Medicinal Chemistry. 24, 9, p. 852-867 16 p.

Research output: Contribution to journalReview article

Inflammatory Bowel Diseases
Vitamin D
Immunity
Vitamin D Deficiency
Therapeutics
11 Citations (Scopus)

Kawasaki disease: etiopathogenesis and novel treatment strategies

Agarwal, S. & Agrawal, D. K., Mar 4 2017, In : Expert Review of Clinical Immunology. 13, 3, p. 247-258 12 p.

Research output: Contribution to journalReview article

Mucocutaneous Lymph Node Syndrome
Coronary Aneurysm
Therapeutics
Systemic Vasculitis
Intravenous Immunoglobulins
5 Citations (Scopus)

Pain and the pathogenesis of biceps tendinopathy

Raney, E. B., Thankam, F. G., Dilisio, M. & Agrawal, D. K., 2017, In : American Journal of Translational Research. 9, 6, p. 2668-2683 16 p., AJTR0052921.

Research output: Contribution to journalReview article

Tendinopathy
Tendons
Pain
Tachykinins
Neurology
8 Citations (Scopus)

Radioprotective agents to prevent cellular damage due to ionizing radiation

Smith, T. A., Kirkpatrick, D. R., Smith, S., Smith, T. K., Pearson, T., Kailasam, A., Herrmann, K. Z., Schubert, J. & Agrawal, D. K., Nov 9 2017, In : Journal of Translational Medicine. 15, 1, 232.

Research output: Contribution to journalReview article

Radiation-Protective Agents
Ionizing radiation
Ionizing Radiation
Medical imaging
Diagnostic Imaging
16 Citations (Scopus)

Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research

Rai, V., Sharma, P. K., Agrawal, S. & Agrawal, D. K., Jan 1 2017, In : Molecular and Cellular Biochemistry. 424, 1-2, p. 123-145 23 p.

Research output: Contribution to journalReview article

Cardiomegaly
Fibrosis
Research
Animals
Animal Models
7 Citations (Scopus)

Role of Vitamin D in Cardiovascular Diseases

Rai, V. & Agrawal, D. K., Dec 1 2017, In : Endocrinology and Metabolism Clinics of North America. 46, 4, p. 1039-1059 21 p.

Research output: Contribution to journalReview article

Vitamin D Deficiency
Vitamin D
Cardiovascular Diseases
Heart Aneurysm
Deficiency Diseases
2 Citations (Scopus)

Single versus combined immunoregulatory approach using PD-1 and CTLA-4 modulators in controlling sepsis

Rudick, C. P., Cornell, D. L. & Agrawal, D. K., Sep 2 2017, In : Expert Review of Clinical Immunology. 13, 9, p. 907-919 13 p.

Research output: Contribution to journalReview article

Sepsis
Survival
beta-Aminoethyl Isothiourea
Systemic Inflammatory Response Syndrome
Phase III Clinical Trials
9 Citations (Scopus)

The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

Parker, T. M., Nguyen, A. H., Rabang, J. R., Patil, A. A. & Agrawal, D. K., Jan 2 2017, In : Brain Injury. 31, 1, p. 2-8 7 p.

Research output: Contribution to journalReview article

Intracranial Hypertension
Therapeutic Uses
Brain Ischemia
PubMed
Chromatin
10 Citations (Scopus)
Atherosclerotic Plaques
Inflammation
Matrix Metalloproteinases
Atherosclerosis
Toll-Like Receptor 1

Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies

Rudick, C. P., Miyamoto, T., Lang, M. S. & Agrawal, D. K., Dec 2 2017, In : Expert Review of Clinical Immunology. 13, 12, p. 1189-1197 9 p.

Research output: Contribution to journalReview article

Periodontitis
Myeloid Cells
Inflammation
Periodontal Diseases
Bone and Bones
20 Citations (Scopus)

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall, S. C. & Agrawal, D. K., May 1 2017, In : Clinical Therapeutics. 39, 5, p. 917-929 13 p.

Research output: Contribution to journalReview article

Vitamin D
Asthma
Clinical Trials
Vitamin D Deficiency
Immunologic Factors
6 Citations (Scopus)

Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis

Garfinkel, R. J., Dilisio, M. & Agrawal, D. K., Jun 20 2017, In : Orthopaedic Journal of Sports Medicine. 5, 6

Research output: Contribution to journalReview article

Articular Cartilage
Vitamin D
Osteoarthritis
Cartilage
Calcitriol Receptors
17 Citations (Scopus)

Vitamin D receptor polymorphism and cancer: An update

Rai, V., Abdo, J., Agrawal, S. & Agrawal, D. K., Aug 1 2017, In : Anticancer Research. 37, 8, p. 3991-4003 13 p.

Research output: Contribution to journalReview article

Calcitriol Receptors
Neoplasms
Vitamin D
Tissue Adhesions
Biological Phenomena
2016
3 Citations (Scopus)

Association of high mobility group BOX-1 and receptor for advanced glycation endproducts with clinicopathological features of haematological malignancies: A systematic review

Nguyen, A. H., Bhavsar, S. B., Riley, E. M., Caponetti, G. C. & Agrawal, D. K., 2016, In : Wspolczesna Onkologia. 20, 6, p. 425-429 5 p.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Neoplasms
Nuclear Proteins
Advanced Glycosylation End Product-Specific Receptor
PubMed
6 Citations (Scopus)
Heart Failure
Biomarkers
Advanced Glycosylation End Product-Specific Receptor
Mortality
Heart Diseases
8 Citations (Scopus)

Clinical value of high mobility group box 1 and the receptor for advanced glycation end-products in head and neck cancer: A systematic review

Nguyen, A., Bhavsar, S., Riley, E., Caponetti, G. & Agrawal, D. K., Oct 1 2016, In : International Archives of Otorhinolaryngology. 20, 4, p. 382-389 8 p.

Research output: Contribution to journalReview article

Head and Neck Neoplasms
PubMed
Neoplasms
Advanced Glycosylation End Product-Specific Receptor
Inflammation
30 Citations (Scopus)

Effects of matrix metalloproteinases on the fate of mesenchymal stem cells

Almalki, S. G. & Agrawal, D. K., Sep 9 2016, In : Stem Cell Research and Therapy. 7, 1, 129.

Research output: Contribution to journalReview article

Stem cells
Matrix Metalloproteinases
Mesenchymal Stromal Cells
Cell Lineage
Tissue Inhibitor of Metalloproteinases

Has Vitamin D had its "time in the sun" for melanoma?

Huerter, C., Vaudreuil, A., Agrawal, D. K. & Nguyen, A. H., Dec 1 2016, In : Journal of Clinical and Aesthetic Dermatology. 9, 12, p. 11-12 2 p.

Research output: Contribution to journalReview article

Solar System
Vitamin D
Melanoma
Neoplasms
Immune System
10 Citations (Scopus)

Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions

Thankam, F. G., Dilisio, M. & Agrawal, D. K., Jun 1 2016, In : Molecular and Cellular Biochemistry. 417, 1-2, p. 17-33 17 p.

Research output: Contribution to journalReview article

Rotator Cuff
Tendons
Infiltration
Muscle
Muscles
2 Citations (Scopus)

Immunological basis for treatment of graft versus host disease after liver transplant

Rai, V., Dietz, N. E. & Agrawal, D. K., May 3 2016, In : Expert Review of Clinical Immunology. 12, 5, p. 583-593 11 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Transplants
Liver
Bone Marrow
T-Lymphocytes
8 Citations (Scopus)

Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

Larson, S. P., Kovilam, O. & Agrawal, D. K., Jan 2 2016, In : Expert Review of Clinical Immunology. 12, 1, p. 39-48 10 p.

Research output: Contribution to journalReview article

Immune System
Ursodeoxycholic Acid
Bile Acids and Salts
Research
Therapeutics
1 Citation (Scopus)

Immunopathogenesis and therapeutic approaches in pediatric celiac disease

Agarwal, S., Kovilam, O., Zach, T. L. & Agrawal, D. K., Aug 2 2016, In : Expert Review of Clinical Immunology. 12, 8, p. 857-869 13 p.

Research output: Contribution to journalReview article

Celiac Disease
Pediatrics
Gluten-Free Diet
Glutens
Hordeum
81 Citations (Scopus)

Mesenchymal stem cells and cutaneous wound healing: Novel methods to increase cell delivery and therapeutic efficacy

Lee, D. E., Ayoub, N. & Agrawal, D. K., Mar 9 2016, In : Stem Cell Research and Therapy. 7, 1, 303.

Research output: Contribution to journalReview article

Stem cells
Mesenchymal Stromal Cells
Wound Healing
Skin
Therapeutics
9 Citations (Scopus)

Pain transduction: a pharmacologic perspective

McEntire, D. M., Kirkpatrick, D. R., Dueck, N. P., Kerfeld, M. J., Smith, T. A., Nelson, T. J., Reisbig, M. & Agrawal, D. K., Aug 2 2016, In : Expert Review of Clinical Pharmacology. 9, 8, p. 1069-1080 12 p.

Research output: Contribution to journalReview article

Acid Sensing Ion Channels
Pain
Research
Pharmacology
Voltage-Gated Sodium Channels
46 Citations (Scopus)
Phosphoric Monoester Hydrolases
Cell Cycle
Phosphotransferases
Cells
Cyclin-Dependent Kinases
4 Citations (Scopus)

Role of risk stratification and genetics in sudden cardiac death

Rai, V. & Agrawal, D. K., 2016, In : Canadian Journal of Physiology and Pharmacology. 95, 3, p. 225-238 14 p.

Research output: Contribution to journalReview article

Sudden Cardiac Death
Incidence
Cardiac Arrhythmias
Ventricular Fibrillation
Primary Prevention
10 Citations (Scopus)

The impact of Vitamin D on asthmatic human airway smooth muscle

Hall, S. C., Fischer, K. D. & Agrawal, D. K., Feb 1 2016, In : Expert Review of Respiratory Medicine. 10, 2, p. 127-135 9 p.

Research output: Contribution to journalReview article

Vitamin D
Airway Remodeling
Smooth Muscle
Asthma
Inflammation