Department of Medical Microbiology and Immunology

Research Output 1978 2019

2019

Alteration of prion strain emergence by nonhost factors

Holec, S. A. M., Yuan, Q. & Bartz, J. C., Jan 1 2019, In : mSphere. 4, 5, e00630-19.

Research output: Contribution to journalArticle

Open Access
Prions
Adsorption
Soil
Endopeptidase K
Digestion
2 Citations (Scopus)

A potential long-acting bictegravir loaded nano-drug delivery system for HIV-1 infection: A proof-of-concept study

Mandal, S., Prathipati, P. K., Belshan, M. & Destache, C. J., Jul 1 2019, In : Antiviral Research. 167, p. 83-88 6 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
HIV Infections
HIV-1
Integrases
Emulsions

Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection

Jackson-Litteken, C. D., Zalud, A. K., Ratliff, C. T., Latham, J. I., Bourret, T. J., Lopez, J. E. & Blevins, J. S., Jan 1 2019, In : Frontiers in cellular and infection microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Ornithodoros
Borrelia
Serine Proteases
Spirochaetales
Infection

CD4+ T cell activation and associated susceptibility to HIV-1 infection in vitro increased following acute resistance exercise in human subjects

Holbrook, A. K., Peterson, H. D., Bianchi, S. A., Macdonald, B. W., Bredahl, E. C., Belshan, M. & Siedlik, J. A., Sep 1 2019, In : Physiological Reports. 7, 18, e14234.

Research output: Contribution to journalArticle

Open Access
HIV Infections
HIV-1
Exercise
T-Lymphocytes
Leg
2 Citations (Scopus)

Cellular and Molecular Mechanisms of Prion Disease

Sigurdson, C. J., Bartz, J. C. & Glatzel, M., Jan 1 2019, In : Annual Review of Pathology: Mechanisms of Disease. 14, p. 497-516 20 p.

Research output: Contribution to journalReview article

Prion Diseases
Prions
Chronic Wasting Disease
Kuru
Bovine Spongiform Encephalopathy
Linezolid
Phase III Clinical Trials
Skin
Infection
Methicillin-Resistant Staphylococcus aureus

DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor

Schabla, N. M., Mondal, K. & Swanson, P. C., Sep 19 2019, In : Journal of molecular cell biology. 11, 9, p. 725-735 11 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
DNA-Binding Proteins
DNA Damage
Ligases
Viral Regulatory and Accessory Proteins
Salmonella
Chromosomes
Throughput
Bacterial Chromosomes
Polymerase Chain Reaction

DksA Controls the Response of the Lyme Disease Spirochete Borrelia burgdorferi to Starvation

Boyle, W. K., Groshong, A. M., Drecktrah, D., Boylan, J. A., Gherardini, F. C., Blevins, J. S., Samuels, D. S. & Bourret, T. J., Feb 15 2019, In : Journal of Bacteriology. 201, 4

Research output: Contribution to journalArticle

Borrelia burgdorferi
Starvation
Regulon
Ticks
Ixodes
Open Access
Enterobacter
Klebsiella pneumoniae
Genome
Enterobacteriaceae
Microbial Drug Resistance

Editorial: New insights and updates on the molecular epidemiology and antimicrobial resistance of MRSA in humans in the whole-genome sequencing era

Coleman, D. C., Shore, A. C., Goering, R. V. & Monecke, S., Jan 1 2019, In : Frontiers in Microbiology. 10, APR, 637.

Research output: Contribution to journalEditorial

Open Access
Molecular Epidemiology
Methicillin-Resistant Staphylococcus aureus
Genome
1 Citation (Scopus)

Emergence of Oxacillin Resistance in Stealth Methicillin-Resistant Staphylococcus aureus Due to mecA Sequence Instability

Goering, R. V., Swartzendruber, E. A., Obradovich, A. E., Tickler, I. A. & Tenover, F. C., Aug 1 2019, In : Antimicrobial agents and chemotherapy. 63, 8

Research output: Contribution to journalArticle

Open Access
Oxacillin
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Anti-Bacterial Agents
Cefoxitin

Engineering a murine cell line for the stable propagation of hamster prions

Bourkas, M. E. C., Arshad, H., Al-Azzawi, Z. A. M., Halgas, O., Shikiya, R. A., Mehrabian, M., Schmitt-Ulms, G., Bartz, J. C. & Watts, J. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 4911-4923 13 p.

Research output: Contribution to journalArticle

Prions
Cricetinae
Cells
Cell Line
Clustered Regularly Interspaced Short Palindromic Repeats

Functional divergence of a global regulatory complex governing fungal filamentation

Polvi, E. J., Veri, A. O., Liu, Z., Hossain, S., Hyde, S., Kim, S. H., Tebbji, F., Sellam, A., Todd, R. T., Xie, J. L., Lin, Z. Y., Wong, C. J., Shapiro, R. S., Whiteway, M., Robbins, N., Gingras, A. C., Selmecki, A. & Cowen, L. E., Jan 1 2019, In : PLoS Genetics. 15, 1, p. e1007901

Research output: Contribution to journalArticle

morphogenesis
Morphogenesis
Candida albicans
divergence
Chromosomes, Human, Pair 6
2 Citations (Scopus)

Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection

Pandya, A. N., Prathipati, P. K., Hegde, P., Li, W., Graham, K. F., Mandal, S., Drescher, K. M., Destache, C. J., Ordway, D., Jackson, M. & Northa, E. J., Mar 1 2019, In : Antimicrobial Agents and Chemotherapy. e02245-18.

Research output: Contribution to journalArticle

Nontuberculous Mycobacteria
Mycobacterium
Lung
Bacterial Load
Infection

lptG contributes to changes in membrane permeability and the emergence of multidrug hypersusceptibility in a cystic fibrosis isolate of Pseudomonas aeruginosa

Harrison, L. B., Fowler, R. C., Abdalhamid, B., Selmecki, A. & Hanson, N. D., Nov 1 2019, In : MicrobiologyOpen. 8, 11, e844.

Research output: Contribution to journalArticle

Open Access
Cystic Fibrosis
Pseudomonas aeruginosa
meropenem
Permeability
doripenem

Streptococcus agalactiae Strains with Chromosomal Deletions Evade Detection with Molecular Methods

Tickler, I. A., Tenover, F. C., Dewell, S., Le, V. M., Blackman, R. N., Goering, R. V., Rogers, A. E., Piwonka, H., Jung-Hynes, B. D., Chen, D. J., Loeffelholz, M. J., Gnanashanmugam, D. & Baron, E. J., Apr 1 2019, In : Journal of clinical microbiology. 57, 4

Research output: Contribution to journalArticle

Streptococcus agalactiae
Geographic Locations
Streptococcus
Hemolysin Proteins
Molecular Pathology

Updating molecular diagnostics for detecting methicillin- susceptible and methicillin-resistant staphylococcus aureus Isolates in Blood Culture Bottles

Tenover, F. C., Tickler, I. A., Le, V. M., Dewell, S., Mendes, R. E. & Goering, R. V., Jan 1 2019, In : Journal of clinical microbiology. 57, 11, e01195-19.

Research output: Contribution to journalArticle

Open Access
Methicillin
Molecular Pathology
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Diagnostic Reagent Kits
2018
2 Citations (Scopus)

Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces

Phan, H. T. M., Bartz, J. C., Ayers, J., Giasson, B. I., Schubert, M., Rodenhausen, K. B., Kananizadeh, N., Li, Y. & Bartelt-Hunt, S. L., Jun 1 2018, In : Colloids and Surfaces B: Biointerfaces. 166, p. 98-107 10 p.

Research output: Contribution to journalArticle

Synucleins
decontamination
Decontamination
Adsorption
adsorption
1 Citation (Scopus)

Assembly of a complete genome sequence for Gemmata obscuriglobus reveals a novel prokaryotic rRNA operon gene architecture

Franke, J. D., Blomberg, W. R., Todd, R. T., Thomas, R. W. & Selmecki, A., May 21 2018, (Accepted/In press) In : Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

rRNA Operon
Operon
rRNA Genes
Genome
Gene Order
5 Citations (Scopus)

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

Hu, G., Liao, K., Niu, F., Yang, L., Dallon, B. W., Callen, S., Tian, C., Shu, J., Cui, J., Sun, Z., Lyubchenko, Y. L., Ka, M., Chen, X-M. & Buch, S., Dec 7 2018, In : Molecular Therapy - Nucleic Acids. 13, p. 450-463 14 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Phagocytosis
Astrocytes
Morphine
Microglia
1 Citation (Scopus)

Attenuation of intestinal epithelial cell migration during cryptosporidium parvum infection involves parasite Cdg7-FLc-1030 RNA-Mediated induction and release of dickkopf-1

Ming, Z., Wang, Y., Gong, A. Y., Zhang, X. T., Li, M., Chen, T., Mathy, N. W., Strauss-Soukup, J. K. & Chen, X-M., Sep 8 2018, In : Journal of Infectious Diseases. 218, 8, p. 1336-1347 12 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Parasitic Diseases
Cell Movement
Epithelial Cells
RNA
Community Health Services
Methicillin
Saudi Arabia
Nose
Staphylococcus aureus

Creatinine downregulates TNF-α in macrophage and T cell lines

Riesberg, L. A., McDonald, T. L., Wang, Y., Chen, X-M., Holzmer, S. W., Tracy, S. M. & Drescher, K. M., Oct 1 2018, In : Cytokine. 110, p. 29-38 10 p.

Research output: Contribution to journalArticle

T-cells
Macrophages
Creatinine
Down-Regulation
Tumor Necrosis Factor-alpha

Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing

Yuan, Q., Telling, G., Bartelt-Hunt, S. L. & Bartz, J. C., Apr 1 2018, In : Journal of Virology. 92, 8, e02191-17.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Prions
prions
Dehydration

Design, implementation, and interpretation of amplification studies for prion detection

Haley, N. J., Richt, J. A., Davenport, K. A., Henderson, D. M., Hoover, E. A., Manca, M., Caughey, B., Marthaler, D., Bartz, J. C. & Gilch, S., Mar 8 2018, (Accepted/In press) In : Prion. p. 1-10 10 p.

Research output: Contribution to journalArticle

Prion Diseases
Prions
Amplification
Hope
Proteostasis Deficiencies

Experimental models of human prion diseases and prion strains

Diack, A. B. & Bartz, J. C., Jan 1 2018, Handbook of Clinical Neurology. Elsevier B.V., p. 69-84 16 p. (Handbook of Clinical Neurology; vol. 153).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prion Diseases
Prions
Theoretical Models
Endopeptidase K
Animal Diseases
2 Citations (Scopus)

Flow Cytometry Analysis of Fungal Ploidy

Todd, R. T., Braverman, A. L. & Selmecki, A., Aug 1 2018, In : Current Protocols in Microbiology. 50, 1, e58.

Research output: Contribution to journalArticle

Ploidies
Flow Cytometry
Fungal Drug Resistance
Single-Cell Analysis
Biological Phenomena
5 Citations (Scopus)

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. OC., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A. & Cowen, L. E., Apr 1 2018, In : PLoS Genetics. 14, 4, e1007319.

Research output: Contribution to journalArticle

azoles
Azoles
antifungal agents
resistance mechanisms
genetic techniques and protocols

IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1

Palmer, V. L., Worth, A. N., Scott, R. L., Perry, G. A., Yan, M., Li, Q. Z. & Swanson, P., Sep 1 2018, In : Cellular Immunology. 331, p. 110-120 11 p.

Research output: Contribution to journalArticle

Interleukin-10
Transgenic Mice
B-Lymphocytes
Autoantibodies
Immunoglobulin M
1 Citation (Scopus)

Independent amplification of co-infected long incubation period low conversion efficiency prion strains

Eckland, T. E., Shikiya, R. A. & Bartz, J. C., Oct 1 2018, In : PLoS Pathogens. 14, 10, p. e1007323

Research output: Contribution to journalArticle

Prions
Prion Diseases
Coinfection
Biological Assay
Protein Isoforms
1 Citation (Scopus)

Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription

Zhao, G. H., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Mathy, N. W. & Chen, X-M., Feb 15 2018, In : Veterinary Parasitology. 251, p. 27-33 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
messenger RNA
Parasites
epithelial cells
transcription (genetics)
1 Citation (Scopus)

Proteomic profiling of HIV-infected T-cells by SWATH mass spectrometry

DeBoer, J., Wojtkiewicz, M. S., Haverland, N., Li, Y., Harwood, E., Leshen, E., George, J. W., Ciborowski, P. & Belshan, M. A., Mar 1 2018, In : Virology. 516, p. 246-257 12 p.

Research output: Contribution to journalArticle

Proteomics
Mass Spectrometry
HIV
T-Lymphocytes
Infection
7 Citations (Scopus)

Range expansion and the origin of USA300 north american epidemic methicillin-resistant Staphylococcus aureus

Challagundla, L., Luo, X., Tickler, I. A., Didelot, X., Coleman, D. C., Shore, A. C., Coombs, G. W., Sordelli, D. O., Brown, E. L., Skov, R., Larsen, A. R., Reyes, J., Robledo, I. E., Vazquez, G. J., Rivera, R., Fey, P. D., Stevenson, K., Wang, S. H., Kreiswirth, B. N., Mediavilla, J. R. & 6 others, Arias, C. A., Planet, P. J., Nolan, R. L., Tenover, F. C., Goering, R. V. & Robinson, D. A., Jan 1 2018, In : mBio. 9, 1, e02016-17.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Clone Cells
Soft Tissue Infections
Genetic Recombination
Genome
1 Citation (Scopus)

Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway

Shaw, J. A., Henard, C. A., Liu, L., Dieckman, L. M., Vázquez-Torres, A. & Bourret, T. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 29, p. 11271-11282 12 p.

Research output: Contribution to journalArticle

Transketolase
Pentoses
Pentose Phosphate Pathway
Salmonella
Salmonella enterica

Spindle dynamics model explains chromosome loss rates in yeast polyploid cells

Jelenic, I., Selmecki, A., Laan, L. & Pavin, N., Aug 6 2018, In : Frontiers in Genetics. 9, AUG, 296.

Research output: Contribution to journalArticle

Polyploidy
Chromosomes
Yeasts
Ploidies
Saccharomyces cerevisiae

Streptococcus agalactiae strains with chromosomal deletions evade detection with molecular methods

Tickler, I. A., Tenover, F. C., Dewell, S., Le, V. M., Blackman, R. N., Goering, R. V., Rogers, A. E., Piwonka, H., Jung-Hynes, B. D., Chen, D. J., Loeffelholz, M. J., Gnanashanmugam, D. & Baron, E. J., Apr 1 2018, In : Journal of clinical microbiology. 57, 4, e02040-18.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Geographic Locations
Streptococcus
Hemolysin Proteins
Molecular Pathology
1 Citation (Scopus)

The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector

Bourret, T. J., Boyle, W. K., Zalud, A. K., Valenzuela, J. G., Oliveira, F. & Lopez, J. E., Jan 1 2018, (Accepted/In press) In : Cellular Microbiology. e12987.

Research output: Contribution to journalArticle

Argasidae
Relapsing Fever
Spirochaetales
Salivary Glands
Ticks

Trans-suppression of defense DEFB1 gene in intestinal epithelial cells following Cryptosporidium parvum infection is associated with host delivery of parasite Cdg7_FLc_1000 RNA

Ming, Z., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Dolata, C. E. & Chen, X-M., Jan 26 2018, (Accepted/In press) In : Parasitology Research. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Parasites
epithelial cells
Epithelial Cells
RNA

Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA

Ming, Z., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Li, Y., Pang, J., Dong, S., Strauss-Soukup, J. K. & Chen, X-M., Jan 1 2018, (Accepted/In press) In : International Journal for Parasitology.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Cryptosporidium parvum
Cadherins
Parasites
RNA
2 Citations (Scopus)

VprBP (DCAF1) regulates RAG1 expression independently of dicer by mediating RAG1 degradation

Max Schabla, N., Perry, G. A., Palmer, V. L. & Swanson, P., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 930-939 10 p.

Research output: Contribution to journalArticle

vpr Gene Products
Protein Binding
Carrier Proteins
Cullin Proteins
V(D)J Recombination
45 Citations (Scopus)

Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene-based approaches

Schürch, A. C., Arredondo-Alonso, S., Willems, R. J. L. & Goering, R. V., Jan 1 2018, (Accepted/In press) In : Clinical Microbiology and Infection.

Research output: Contribution to journalArticle

Bacterial Typing Techniques
Single Nucleotide Polymorphism
Genome
Genes
Molecular Epidemiology
2017
22 Citations (Scopus)

A long noncoding RNA, lincRNA-Tnfaip3, acts as a coregulator of NF-κB to modulate inflammatory gene transcription in mouse macrophages

Ma, S., Ming, Z., Gong, A. Y., Wang, Y., Chen, X., Hu, G., Zhou, R., Shibata, A., Swanson, P. & Chen, X-M., Mar 1 2017, In : FASEB Journal. 31, 3, p. 1215-1225 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Macrophages
Transcription
Tumor Necrosis Factor-alpha
Genes
12 Citations (Scopus)

An enhanced emtricitabine-loaded long-acting nanoformulation for prevention or treatment of HIV infection

Mandal, S., Belshan, M. A., Holec, A., Zhou, Y. & Destache, C. J., Jan 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01475-16.

Research output: Contribution to journalArticle

HIV Infections
Blood Cells
Nucleosides
Inhibitory Concentration 50
HIV-1
3 Citations (Scopus)

Complement regulatory protein factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis

Kane, S. J., Farley, T. K., Gordon, E. O., Estep, J., Bender, H. R., Moreno, J. A., Bartz, J. C., Telling, G. C., Pickering, M. C. & Zabel, M. D., Dec 1 2017, In : Journal of Immunology. 199, 11, p. 3821-3827 7 p.

Research output: Contribution to journalArticle

Complement Factor H
Prions
Complement System Proteins
Prion Diseases
Follicular Dendritic Cells
6 Citations (Scopus)

Continued expansion of USA300-like methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in the United States

Tickler, I. A., Goering, R. V., Mediavilla, J. R., Kreiswirth, B. N. & Tenover, F. C., Feb 1 2017, (Accepted/In press) In : Diagnostic Microbiology and Infectious Disease.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Mupirocin
Levofloxacin
Clindamycin
Multiple Drug Resistance
7 Citations (Scopus)
Cryptosporidium parvum
Epigenomics
Parasites
Epithelial Cells
RNA
10 Citations (Scopus)

Delivery of parasite RNA transcripts into infected epithelial cells during cryptosporidium infection and its potential impact on host gene transcription

Wang, Y., Gong, A. Y., Ma, S., Chen, X., Li, Y., Su, C. J., Norall, D., Chen, J., Strauss-Soukup, J. K. & Chen, X-M., Feb 15 2017, In : Journal of Infectious Diseases. 215, 4, p. 636-643 8 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidium
Parasites
Epithelial Cells
RNA
1 Citation (Scopus)

Draft genome sequence of the mucoid Pseudomonas aeruginosa clinical isolate PA34

Harrison, L. B. & Hanson, N. D., Nov 1 2017, In : Genome Announcements. 5, 46, e01307-17.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Genome
Cystic Fibrosis
Lung