Department of Medical Microbiology and Immunology

Research Output 1978 2018

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2018

Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces

Phan, H. T. M., Bartz, J. C., Ayers, J., Giasson, B. I., Schubert, M., Rodenhausen, K. B., Kananizadeh, N., Li, Y. & Bartelt-Hunt, S. L. Jun 1 2018 In : Colloids and Surfaces B: Biointerfaces. 166, p. 98-107 10 p.

Research output: Contribution to journalArticle

alpha-Synuclein
decontamination
Decontamination
Adsorption
adsorption

Assembly of a complete genome sequence for Gemmata obscuriglobus reveals a novel prokaryotic rRNA operon gene architecture

Franke, J. D., Blomberg, W. R., Todd, R. T., Thomas, R. W. & Selmecki, A. M. May 21 2018 (Accepted/In press) In : Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

rRNA Operon
Operon
rRNA Genes
Genome
Gene Order

Creatinine downregulates TNF-α in macrophage and T cell lines

Riesberg, L. A., McDonald, T. L., Wang, Y., Chen, X. M., Holzmer, S. W., Tracy, S. M. & Drescher, K. M. Oct 1 2018 In : Cytokine. 110, p. 29-38 10 p.

Research output: Contribution to journalArticle

Cerium
Creatinine
Down-Regulation
Tumor Necrosis Factor-alpha
Macrophages

Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing

Yuan, Q., Telling, G., Bartelt-Hunt, S. L. & Bartz, J. C. Apr 1 2018 In : Journal of Virology. 92, 8, e02191-17

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Prions
prions
Dehydration

Design, implementation, and interpretation of amplification studies for prion detection

Haley, N. J., Richt, J. A., Davenport, K. A., Henderson, D. M., Hoover, E. A., Manca, M., Caughey, B., Marthaler, D., Bartz, J. & Gilch, S. Mar 8 2018 (Accepted/In press) In : Prion. p. 1-10 10 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Scrapie
Creutzfeldt-Jakob Syndrome
Prion Diseases
Prions

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. OC., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A. & Cowen, L. E. Apr 1 2018 In : PLoS Genetics. 14, 4, e1007319

Research output: Contribution to journalArticle

azoles
Azoles
antifungal agents
resistance mechanisms
genetic techniques and protocols

Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription

Zhao, G. H., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Mathy, N. W. & Chen, X. M. Feb 15 2018 In : Veterinary Parasitology. 251, p. 27-33 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidium
Intestinal Mucosa
messenger RNA
intestinal mucosa

Proteomic profiling of HIV-infected T-cells by SWATH mass spectrometry

DeBoer, J., Wojtkiewicz, M. S., Haverland, N., Li, Y., Harwood, E., Leshen, E., George, J. W., Ciborowski, P. & Belshan, M. Mar 1 2018 In : Virology. 516, p. 246-257 12 p.

Research output: Contribution to journalArticle

Proteomics
Mass Spectrometry
HIV
T-Lymphocytes
Infection

Range expansion and the origin of USA300 north american epidemic methicillin-resistant Staphylococcus aureus

Challagundla, L. , Luo, X. , Tickler, I. A. , Didelot, X. , Coleman, D. C. , Shore, A. C. , Coombs, G. W. , Sordelli, D. O. , Brown, E. L. , Skov, R. , Larsen, A. R. , Reyes, J. , Robledo, I. E. , Vazquez, G. J. , Rivera, R. , Fey, P. D. , Stevenson, K. , Wang, S. H. , Kreiswirth, B. N. , Mediavilla, J. R. & 6 others Arias, C. A., Planet, P. J., Nolan, R. L., Tenover, F. C., Goering, R. V. & Robinson, D. A. Jan 1 2018 In : mBio. 9, 1, e02016-17

Research output: Contribution to journalArticle

Founder Effect
Genetic Drift
Fluoroquinolones
Population Genetics
Methicillin-Resistant Staphylococcus aureus

Trans-suppression of defense DEFB1 gene in intestinal epithelial cells following Cryptosporidium parvum infection is associated with host delivery of parasite Cdg7_FLc_1000 RNA

Ming, Z., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Dolata, C. E. & Chen, X. M. Jan 26 2018 (Accepted/In press) In : Parasitology Research. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidium
Intestinal Mucosa
intestinal mucosa
Parasites

Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA

Ming, Z., Gong, A. Y., Wang, Y., Zhang, X. T., Li, M., Li, Y., Pang, J., Dong, S., Strauss-Soukup, J. K. & Chen, X. M. Jan 1 2018 (Accepted/In press) In : International Journal for Parasitology.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Cryptosporidium parvum
Cadherins
Parasites
RNA
1 Citations

Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene-based approaches

Schürch, A. C., Arredondo-Alonso, S., Willems, R. J. L. & Goering, R. V. Jan 1 2018 (Accepted/In press) In : Clinical Microbiology and Infection.

Research output: Contribution to journalArticle

Bacterial Typing Techniques
Single Nucleotide Polymorphism
Genome
Genes
Molecular Epidemiology
2017
8 Citations

A long noncoding RNA, lincRNA-Tnfaip3, acts as a coregulator of NF-κB to modulate inflammatory gene transcription in mouse macrophages

Ma, S., Ming, Z., Gong, A. Y., Wang, Y., Chen, X., Hu, G., Zhou, R., Shibata, A., Swanson, P. C. & Chen, X. M. Mar 1 2017 In : FASEB Journal. 31, 3, p. 1215-1225 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Macrophages
Transcription
Tumor Necrosis Factor-alpha
Genes
4 Citations

An enhanced emtricitabine-loaded long-acting nanoformulation for prevention or treatment of HIV infection

Mandal, S., Belshan, M., Holec, A., Zhou, Y. & Destache, C. J. Jan 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 1, e01475-16

Research output: Contribution to journalArticle

HIV Infections
Blood Cells
Nucleosides
Inhibitory Concentration 50
HIV-1
2 Citations

Complement regulatory protein factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis

Kane, S. J., Farley, T. K., Gordon, E. O., Estep, J., Bender, H. R., Moreno, J. A., Bartz, J., Telling, G. C., Pickering, M. C. & Zabel, M. D. Dec 1 2017 In : Journal of Immunology. 199, 11, p. 3821-3827 7 p.

Research output: Contribution to journalArticle

Complement Factor H
Prions
Complement System Proteins
Prion Diseases
Follicular Dendritic Cells
1 Citations

Continued expansion of USA300-like methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in the United States

Tickler, I. A., Goering, R. V., Mediavilla, J. R., Kreiswirth, B. N. & Tenover, F. C. Feb 1 2017 (Accepted/In press) In : Diagnostic Microbiology and Infectious Disease.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Mupirocin
Levofloxacin
Clindamycin
Multiple Drug Resistance
5 Citations
Cryptosporidium parvum
Epigenomics
Parasites
Epithelial Cells
RNA
7 Citations

Delivery of parasite RNA transcripts into infected epithelial cells during cryptosporidium infection and its potential impact on host gene transcription

Wang, Y., Gong, A. Y., Ma, S., Chen, X., Li, Y., Su, C. J., Norall, D., Chen, J., Strauss-Soukup, J. K. & Chen, X. M. Feb 15 2017 In : Journal of Infectious Diseases. 215, 4, p. 636-643 8 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidium
Parasites
Epithelial Cells
RNA

Draft genome sequence of the mucoid Pseudomonas aeruginosa clinical isolate PA34

Harrison, L. B. & Hanson, N. D. Nov 1 2017 In : Genome Announcements. 5, 46, e01307-17

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Genome
Cystic Fibrosis
Lung

High-resolution melting analysis for rapid detection of sequence type 131 Escherichia coli

Harrison, L. B. & Hanson, N. D. Jun 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 6, e00265-17

Research output: Contribution to journalArticle

Freezing
Escherichia coli
Multilocus Sequence Typing
Principal Component Analysis
Sequence Analysis

Impact of CLSI and EUCAST Cefepime breakpoint changes on the susceptibility reporting for Enterobacteriaceae

Bork, J. T., Heil, E. L., Leekha, S., Fowler, R. C., Hanson, N. D., Majumdar, A. & Johnson, J. K. 2017 (Accepted/In press) In : Diagnostic Microbiology and Infectious Disease.

Research output: Contribution to journalArticle

Enterobacteriaceae
Enterobacter
Klebsiella
Ceftriaxone
beta-Lactamases

Lineage II (Serovar 1/2a and 1/2c) Human Listeria monocytogenes Pulsed-Field Gel Electrophoresis Types Divided into PFGE Groups Using the Band Patterns below 145.5 kb

Lopez-Valladares, G., Danielsson-Tham, M. L., Goering, R. V. & Tham, W. Jan 1 2017 In : Foodborne Pathogens and Disease. 14, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

Pulsed Field Gel Electrophoresis
Listeria monocytogenes
pulsed-field gel electrophoresis
serotypes
Serogroup

Magnesium homeostasis protects Salmonella against nitrooxidative stress

Bourret, T. J., Liu, L., Shaw, J. A., Husain, M. & Vázquez-Torres, A. Dec 1 2017 In : Scientific Reports. 7, 1, 15083

Research output: Contribution to journalArticle

Reactive Nitrogen Species
Salmonella
Magnesium
Homeostasis
Nitric Oxide
2 Citations

Ploidy variation in fungi: Polyploidy, aneuploidy, and genome evolution

Todd, R. T., Forche, A. & Selmecki, A. Jul 1 2017 In : Microbiology Spectrum. 5, 4, FUNK-0051-2016

Research output: Contribution to journalArticle

Genome Size
polyploidy
Aptitude
Polyploidy
ploidy
6 Citations

Prion replication without host adaptation during interspecies transmissions

Bian, J., Khaychuk, V., Angers, R. C., Fernández-Borges, N., Vidal, E., Meyerett-Reid, C., Kim, S., Calvi, C. L., Bartz, J. C., Hoover, E. A., Agrimi, U., Richt, J. A., Castilla, J. & Telling, G. C. Jan 31 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1141-1146 6 p.

Research output: Contribution to journalArticle

Prions
Horses
Deer
Mink
Prion Diseases
1 Citations

PrPScformation and clearance as determinants of prion tropism

Shikiya, R. A., Langenfeld, K. A., Eckland, T. E., Trinh, J., Holec, S. A. M., Mathiason, C. K., Kincaid, A. E. & Bartz, J. C. Mar 1 2017 In : PLoS Pathogens. 13, 3, e1006298

Research output: Contribution to journalArticle

Mink
Tropism
Prions
Brain Diseases
Spleen

Role of Fly Cleaning Behavior on Carriage of Escherichia coli and Pseudomonas aeruginosa

Jacques, B. J., Bourret, T. J. & Shaffer, J. J. Nov 7 2017 In : Journal of medical entomology. 54, 6, p. 1712-1717 6 p.

Research output: Contribution to journalArticle

Sarcophagidae
Drosophila virilis
Sarcophaga bullata
Houseflies
Grooming
8 Citations

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Xie, J. L., Qin, L., Miao, Z., Grys, B. T., Diaz, J. D. L. C., Ting, K., Krieger, J. R., Tong, J., Tan, K., Leach, M. D., Ketela, T., Moran, M. F., Krysan, D. J., Boone, C., Andrews, B. J., Selmecki, A., Ho Wong, K., Robbins, N. & Cowen, L. E. Dec 1 2017 In : Nature Communications. 8, 1, 499

Research output: Contribution to journalArticle

Candida
Candida albicans
Drug Resistance
Echinocandins
Cell Cycle
2 Citations

The Influence of Polyploidy on the Evolution of Yeast Grown in a Sub-Optimal Carbon Source

Scott, A. L., Richmond, P. A., Dowell, R. D. & Selmecki, A. M. Oct 1 2017 In : Molecular Biology and Evolution. 34, 10, p. 2690-2703 14 p.

Research output: Contribution to journalArticle

polyploidy
Polyploidy
yeast
mutation
Carbon
5 Citations

The Magnaporthe oryzae nitrooxidative stress response suppresses rice innate immunity during blast disease

Marroquin-Guzman, M., Hartline, D., Wright, J. D., Elowsky, C., Bourret, T. J. & Wilson, R. A. Apr 18 2017 In : Nature Microbiology. 2, 17054

Research output: Contribution to journalArticle

Magnaporthe
Innate Immunity
Plant Immunity
Reactive Oxygen Species
Plant Pathology
4 Citations

The NF-κB-Responsive long noncoding RNA FIRRE regulates posttranscriptional regulation of inflammatory gene expression through interacting with hnRNPU

Lu, Y., Liu, X., Xie, M., Liu, M., Ye, M., Li, M., Chen, X. M., Li, X. & Zhou, R. Nov 15 2017 In : Journal of Immunology. 199, 10, p. 3571-3582 12 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Gene Expression Regulation
Heterogeneous-Nuclear Ribonucleoprotein U
AU Rich Elements
Epithelial Cells
2016
2 Citations

Absence of caveolin-1 leads to delayed development of chronic lymphocytic leukemia in Eμ-TCL1 mouse model

Shukla, A., Cutucache, C. E., Sutton, G. L., Pitner, M. A., Rai, K., Rai, S., Opavsky, R., Swanson, P. C. & Joshi, S. S. Jan 1 2016 In : Experimental Hematology. 44, 1, p. 30-37.e1

Research output: Contribution to journalArticle

Caveolin 1
B-Cell Chronic Lymphocytic Leukemia
Lymph Nodes
Bone Marrow
Gene Expression Profiling
3 Citations

Beyond muscles: The untapped potential of creatine

Riesberg, L. A., Weed, S. A., McDonald, T. L., Eckerson, J. M. & Drescher, K. M. Aug 1 2016 In : International Immunopharmacology. 37, p. 31-42 12 p.

Research output: Contribution to journalArticle

Creatine
Muscles
Immune System
Sarcopenia
Wasting Syndrome
1 Citations

Characterization of methicillin-resistant Staphylococcus aureus isolated at Tripoli Medical Center, Libya, between 2008 and 2014

BenDarif, E., Khalil, A., Rayes, A., Bennour, E., Dhawi, A., Lowe, J. J., Gibbs, S. & Goering, R. V. Dec 1 2016 In : Journal of Medical Microbiology. 65, 12, p. 1472-1475 4 p., 000384

Research output: Contribution to journalArticle

Libya
Methicillin-Resistant Staphylococcus aureus
Fluoroquinolones
Infection Control
Population
5 Citations

Cryptosporidium parvum infection attenuates the ex vivo propagation of murine intestinal enteroids

Zhang, X. T., Gong, A. Y., Wang, Y., Chen, X., Lim, S. Y. S., Dolata, C. E. & Chen, X. M. Dec 1 2016 In : Physiological Reports. 4, 24, e13060

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidium
Infection
Cryptosporidiosis
Low Density Lipoprotein Receptor-Related Protein-5
5 Citations

Cyclophilin B enhances HIV-1 infection

DeBoer, J., Madson, C. J. & Belshan, M. Feb 1 2016 In : Virology. 489, p. 282-291 10 p.

Research output: Contribution to journalArticle

HIV Infections
HIV-1
Nuclear Localization Signals
Cell Nucleus Active Transport
Immunophilins
2 Citations

Evaluation of CTX-M steady-state mRNA, mRNA half-life and protein production in various STs of Escherichia coli

Geyer, C. N., Fowler, R. C., Johnson, J. R., Johnston, B., Weissman, S. J., Hawkey, P. & Hanson, N. D. Mar 1 2016 In : Journal of Antimicrobial Chemotherapy. 71, 3, p. 607-616 10 p., dkv388

Research output: Contribution to journalArticle

Half-Life
Escherichia coli
Messenger RNA
Proteins
beta-Lactams
2 Citations

IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Dixon, N., Fowler, R. C., Yoshizumi, A., Horiyama, T., Ishii, Y., Harrison, L., Geyer, C. N., Moland, E. S., Thomson, K. & Hanson, N. D. Oct 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 6418-6421 4 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
Proteus mirabilis
beta-Lactamases
Ceftazidime
Integrons
5 Citations

Incongruity between prion conversion and incubation period following coinfection

Langenfeld, K. A., Shikiya, R. A., Kincaid, A. E. & Bartz, J. C. Jun 1 2016 In : Journal of Virology. 90, 12, p. 5715-5723 9 p.

Research output: Contribution to journalArticle

Mink
Prions
prions
Brain Diseases
Coinfection
6 Citations

Investigation of the HIV-1 matrix interactome during virus replication

Li, Y., Frederick, K. M., Haverland, N. A., Ciborowski, P. & Belshan, M. Feb 1 2016 In : Proteomics - Clinical Applications. 10, 2, p. 156-163 8 p.

Research output: Contribution to journalArticle

Virus Replication
Viruses
HIV-1
Y-Box-Binding Protein 1
Virus Diseases
23 Citations

LincRNA-Cox2 modulates TNF-α-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications

Tong, Q., Gong, A. Y., Zhang, X. T., Lin, C., Ma, S., Chen, J., Hu, G. & Chen, X. M. Mar 1 2016 In : FASEB Journal. 30, 3, p. 1187-1197 11 p.

Research output: Contribution to journalArticle

Histone Code
Long Noncoding RNA
Nucleosomes
Transcription
Epigenomics
26 Citations

LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling

Hu, G., Gong, A. Y., Wang, Y., Ma, S., Chen, X., Chen, J., Su, C. J., Shibata, A., Strauss-Soukup, J. K., Drescher, K. M. & Chen, X. M. Mar 15 2016 In : Journal of Immunology. 196, 6, p. 2799-2808 10 p.

Research output: Contribution to journalArticle

Genetic Transcription
Long Noncoding RNA
Chromatin Assembly and Disassembly
Sucrose
Macrophages
5 Citations

NF45 and NF90 bind HIV-1 RNA and modulate HIV gene expression

Li, Y. & Belshan, M. Feb 16 2016 In : Viruses. 8, 2, 23

Research output: Contribution to journalArticle

Nuclear Factor 90 Proteins
HIV-1
HIV
RNA
Gene Expression

Plasmid-mediated β-lactamases: Nomadic microbial assassins lurking in multidrug resistant gram-negative strains

Connelly, C. M., Torres, M. P., Lechner, J., Porter, L. R., Morrow, S. & Hanson, N. D. Nov 1 2016 In : BioTechniques. 61, 5, p. 272-275 4 p.

Research output: Contribution to journalArticle

Enterprise resource management
beta-Lactamases
Plasmids
6 Citations

Prion strain diversity

Bartz, J. C. 2016 In : Cold Spring Harbor perspectives in medicine. 6, 12, a024349

Research output: Contribution to journalArticle

Prions
Prion Diseases
Phenotype
Animal Diseases
Tropism
7 Citations

Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a

Haney, S. L., Upchurch, G. M., Opavska, J., Klinkebiel, D., Hlady, R. A., Suresh, A., Pirruccello, S. J., Shukla, V., Lu, R., Costinean, S., Rizzino, A., Karpf, A. R., Joshi, S., Swanson, P. & Opavsky, R. May 10 2016 In : Cell Reports. 15, 6, p. 1190-1201 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Genes
Loss of Heterozygosity
Methylation
Cytosine
3 Citations
nasal cavity
Prions
Nasal Cavity
prions
hamsters
1 Citations

Structural and mutagenic analysis of metallo-β-lactamase IMP-18

Furuyama, T., Nonomura, H., Ishii, Y., Hanson, N. D. & Shimizu-Ibuka, A. Sep 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5521-5526 6 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
beta-Lactamases
meropenem
Carbapenems
beta-Lactams
5 Citations

The nucleotide excision repair pathway protects Borrelia burgdorferi from nitrosative stress in Ixodes scapularis ticks

Bourret, T. J., Lawrence, K. A., Shaw, J. A., Lin, T., Norris, S. J. & Gherardini, F. C. Sep 7 2016 In : Frontiers in Microbiology. 7, SEP, 1397

Research output: Contribution to journalArticle

Ixodes
Borrelia burgdorferi
Reactive Nitrogen Species
Ticks
DNA Repair