• 2152 Citations
  • 25 h-Index
1985 …2018
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  • 3 Similar Profiles
Nanoparticles Medicine & Life Sciences
Pharmacokinetics Medicine & Life Sciences
HIV-1 Medicine & Life Sciences
Rilpivirine Medicine & Life Sciences
HIV Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Aminoglycosides Medicine & Life Sciences

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Projects 2008 2018

Nanoparticles
HIV
Rilpivirine
Tenofovir
Drug Combinations

Once Monthly Antiretroviral Nanoparticles for HIV-1 Treatment

Destache, C. J.

National Institutes of Health

6/15/115/31/13

Project: Research projectHigh Priority, Short Term Project Award

Nanoparticles
HIV-1
Therapeutics
Macaca
Macaca nemestrina

Pharmacology of Antiretroviral Nanoparticle Micelles

Destache, C. J.

National Institutes of Health

6/1/085/31/11

Project: Research projectAcademic Research Enhancement Awards (AREA)

Micelles
Nanoparticles
HIV-1
Pharmacology
efavirenz

Research Output 1985 2018

Development and validation of LC–MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Prathipati, P. K., Mandal, S. & Destache, C. J., Jan 1 2018, (Accepted/In press) In : Biomedical Chromatography. e4379.

Research output: Contribution to journalArticle

Plasma (human)
formic acid
Liquid chromatography
Mass spectrometers
Mass spectrometry
2 Citations

Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

Pattnaik, A., Palermo, N., Sahoo, B. R., Yuan, Z., Hu, D., Annamalai, A. S., Vu, H. L. X., Correas, I., Prathipati, P. K., Destache, C. J., Li, Q., Osorio, F. A., Pattnaik, A. K. & Xiang, S. H., Mar 1 2018, In : Antiviral Research. 151, p. 78-86 9 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
Virus Replication
Computer Simulation
RNA Replicase
Catalytic Domain

LC-MS/MS method for the simultaneous determination of tenofovir, emtricitabine, elvitegravir and rilpivirine in dried blood spots

Prathipati, P. K., Mandal, S. & Destache, C. J., Jan 1 2018, (Accepted/In press) In : Biomedical Chromatography.

Research output: Contribution to journalArticle

Rilpivirine
Tenofovir
formic acid
Mass spectrometry
Blood
1 Citations

Long-acting parenteral combination antiretroviral loaded nano-drug delivery system to treat chronic HIV-1 infection: A humanized mouse model study

Mandal, S., Kang, G., Prathipati, P. K., Fan, W., Li, Q. & Destache, C. J., Aug 1 2018, In : Antiviral Research. 156, p. 85-91 7 p.

Research output: Contribution to journalArticle

Virus Diseases
Drug Delivery Systems
Viral Load
HIV-1
Nanoparticles
7 Citations

An enhanced emtricitabine-loaded long-acting nanoformulation for prevention or treatment of HIV infection

Mandal, S., Belshan, M. A., Holec, A., Zhou, Y. & Destache, C. J., Jan 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01475-16.

Research output: Contribution to journalArticle

HIV Infections
Blood Cells
Nucleosides
Inhibitory Concentration 50
HIV-1