• 824 Citations
  • 15 h-Index
20082019

Research output per year

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Research Output

  • 824 Citations
  • 15 h-Index
  • 20 Article
  • 1 Review article
2019

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

Li, W., Stevens, C. M., Pandya, A. N., Darzynkiewicz, Z., Bhattarai, P., Tong, W., Gonzalez-Juarrero, M., North, E. J., Zgurskaya, H. I. & Jackson, M., Jun 14 2019, In : ACS Infectious Diseases. 5, 6, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles

Gumireddy, A., Christman, R., Kumari, D., Tiwari, A., North, E. J. & Chauhan, H., May 1 2019, In : AAPS PharmSciTech. 20, 4, 145.

Research output: Contribution to journalArticle

8 Scopus citations
2018

MmpL3 as a target for the treatment of drug-resistant nontuberculous mycobacterial infections

Li, W., Yazidi, A., Pandya, A. N., Hegde, P., Tong, W., de Moura, V. C. N., North, E. J., Sygusch, J. & Jackson, M., Jul 10 2018, In : Frontiers in Microbiology. 9, JUL, 1547.

Research output: Contribution to journalArticle

12 Scopus citations
2017

A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Pandya, A. N., Villa, E. & North, E. J., Mar 29 2017, In : Tetrahedron Letters. 58, 13, p. 1276-1279 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Design, synthesis and evaluation of indole-2-carboxamides with pan anti-mycobacterial activity

Franz, N. D., Belardinelli, J. M., Kaminski, M. A., Dunn, L. C., Calado Nogueira de Moura, V., Blaha, M. A., Truong, D. D., Li, W., Jackson, M. & North, E. J., Jul 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 14, p. 3746-3755 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synergistic interactions of MmpL3 inhibitors with antitubercular compounds in vitro

Li, W., Sanchez-Hidalgo, A., Jones, V., De Moura, V. C. N., North, E. J. & Jackson, M., Apr 1 2017, In : Antimicrobial agents and chemotherapy. 61, 4, e02399.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

Grzegorzewicz, A. E., Eynard, N., Quémard, A., North, E. J., Margolis, A., Lindenberger, J. J., Jones, V., Korduláková, J., Brennan, P. J., Lee, R. E., Ronning, D. R., McNeil, M. R. & Jackson, M., Jan 8 2016, In : ACS Infectious Diseases. 1, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Opportunities and Challenges for Natural Products as Novel Antituberculosis Agents

Farah, S. I., Abdelrahman, A. A., North, E. J. & Chauhan, H., Jan 1 2016, In : Assay and Drug Development Technologies. 14, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3

Li, W., Obregón-Henao, A., Wallach, J. B., North, E. J., Lee, R. E., Gonzalez-Juarrero, M., Schnappinger, D. & Jackson, M., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2014

A screen for and validation of prodrug antimicrobials

Fleck, L. E., North, E. J., Lee, R. E., Mulcahy, L. R., Casadei, G. & Lewis, K., Mar 1 2014, In : Antimicrobial agents and chemotherapy. 58, 3, p. 1410-1419 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

In vitro and in vivo activities of hpi1, a selective antimicrobial against helicobacter pylori

Gavrish, E., Shrestha, B., Chen, C., Lister, I., North, E. J., Yang, L., Lee, R. E., Han, A., Williams, B., Charnuska, D., Coleman, K., Lewis, K. & LaFleura, M. D., Jun 2014, In : Antimicrobial agents and chemotherapy. 58, 6, p. 3255-3260 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics

Jeffrey North, E., Jackson, M. & Lee, R. E., Jan 1 2014, In : Current Pharmaceutical Design. 20, 27, p. 4357-4378 22 p.

Research output: Contribution to journalReview article

40 Scopus citations

Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

Li, W., Upadhyay, A., Fontes, F. L., North, E. J., Wang, Y., Crans, D. C., Grzegorzewicz, A. E., Jones, V., Franzblau, S. G., Lee, R. E., Crick, D. C. & Jackson, M., Nov 1 2014, In : Antimicrobial agents and chemotherapy. 58, 11, p. 6413-6423 11 p.

Research output: Contribution to journalArticle

110 Scopus citations
2013

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3- heteroaryl ureas with improved in vitro pharmacokinetic properties

North, E. J., Scherman, M. S., Bruhn, D. F., Scarborough, J. S., Maddox, M. M., Jones, V., Grzegorzewicz, A., Yang, L., Hess, T., Morisseau, C., Jackson, M., McNeil, M. R. & Lee, R. E., May 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2587-2599 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Potentiation of azole antifungals by 2-adamantanamine

LaFleur, M. D., Sun, L., Lister, I., Keating, J., Nantel, A., Long, L., Ghannoum, M., North, J., Lee, R. E., Coleman, K., Dahl, T. & Lewis, K., Aug 1 2013, In : Antimicrobial agents and chemotherapy. 57, 8, p. 3585-3592 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Grzegorzewicz, A. E., Pham, H., Gundi, V. A. K. B., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E. M., Korduláková, J., Chavadi, S. S., Morisseau, C., Lenaerts, A. J., Lee, R. E., McNeil, M. R. & Jackson, M., Apr 2012, In : Nature Chemical Biology. 8, 4, p. 334-341 8 p.

Research output: Contribution to journalArticle

230 Scopus citations

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

Scherman, M. S., North, E. J., Jones, V., Hess, T. N., Grzegorzewicz, A. E., Kasagami, T., Kim, I. H., Merzlikin, O., Lenaerts, A. J., Lee, R. E., Jackson, M., Morisseau, C. & McNeil, M. R., May 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 10, p. 3255-3262 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
2011

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

Brown, J. R., North, E. J., Hurdle, J. G., Morisseau, C., Scarborough, J. S., Sun, D., Korduláková, J., Scherman, M. S., Jones, V., Grzegorzewicz, A., Crew, R. M., Jackson, M., McNeil, M. R. & Lee, R. E., Sep 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 18, p. 5585-5595 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
2010

Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors

North, E. J., Howard, A. L., Wanjala, I. W., Pham, T. C. T., Baker, D. L. & Parrill, A. L., Apr 22 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3095-3105 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs

North, E. J., Osborne, D. A., Bridson, P. K., Baker, D. L. & Parrill, A. L., May 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 9, p. 3433-3442 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Molecular recognition in the sphingosine 1-phosphate receptor family

Pham, T. C. T., Fells, J. I., Osborne, D. A., North, E. J., Naor, M. M. & Parrill, A. L., Jun 1 2008, In : Journal of Molecular Graphics and Modelling. 26, 8, p. 1189-1201 13 p.

Research output: Contribution to journalArticle

27 Scopus citations