• 678 Citations
  • 14 h-Index
20082019
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Research Output 2008 2019

  • 678 Citations
  • 14 h-Index
  • 20 Article
  • 1 Review article
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Article
2019

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

Li, W., Stevens, C. M., Pandya, A. N., Darzynkiewicz, Z., Bhattarai, P., Tong, W., Gonzalez-Juarrero, M., North, E. J., Zgurskaya, H. I. & Jackson, M., Jan 1 2019, In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Open Access
Proton-Motive Force
Mycolic Acids
Missense Mutation
Mycobacterium tuberculosis
Mutation
1 Citation (Scopus)

Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles

Gumireddy, A., Christman, R., Kumari, D., Tiwari, A., North, E. J. & Chauhan, H., May 1 2019, In : AAPS PharmSciTech. 20, 4, 145.

Research output: Contribution to journalArticle

Curcumin
curcumin
resveratrol
nanoparticles
Nanoparticles
2018
4 Citations (Scopus)

MmpL3 as a target for the treatment of drug-resistant nontuberculous mycobacterial infections

Li, W., Yazidi, A., Pandya, A. N., Hegde, P., Tong, W., de Moura, V. C. N., North, E. J., Sygusch, J. & Jackson, M., Jul 10 2018, In : Frontiers in Microbiology. 9, JUL, 1547.

Research output: Contribution to journalArticle

Mycobacterium
Mycobacterium tuberculosis
Lung
Infection
Mycolic Acids
2017
3 Citations (Scopus)

A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

Pandya, A. N., Villa, E. & North, E. J., Mar 29 2017, In : Tetrahedron Letters. 58, 13, p. 1276-1279 4 p.

Research output: Contribution to journalArticle

Quinazolines
Amines
Metals
Derivatives
Ligands
14 Citations (Scopus)

Design, synthesis and evaluation of indole-2-carboxamides with pan anti-mycobacterial activity

Franz, N. D., Belardinelli, J. M., Kaminski, M. A., Dunn, L. C., Calado Nogueira de Moura, V., Blaha, M. A., Truong, D. D., Li, W., Jackson, M. & North, E. J., Jul 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 14, p. 3746-3755 10 p.

Research output: Contribution to journalArticle

Mycobacterium
Smegma
Mycolic Acids
Anti-Bacterial Agents
Cytotoxicity
16 Citations (Scopus)

Synergistic interactions of MmpL3 inhibitors with antitubercular compounds in vitro

Li, W., Sanchez-Hidalgo, A., Jones, V., De Moura, V. C. N., North, E. J. & Jackson, M., Apr 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 4, e02399.

Research output: Contribution to journalArticle

bedaquiline
Clofazimine
Mycolic Acids
Lactams
Rifampin
2016
14 Citations (Scopus)

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

Grzegorzewicz, A. E., Eynard, N., Quémard, A., North, E. J., Margolis, A., Lindenberger, J. J., Jones, V., Korduláková, J., Brennan, P. J., Lee, R. E., Ronning, D. R., McNeil, M. R. & Jackson, M., Jan 8 2016, In : ACS Infectious Diseases. 1, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

Thioacetazone
Hydro-Lyases
Mycobacterium tuberculosis
Prodrugs
dimethylaniline monooxygenase (N-oxide forming)
4 Citations (Scopus)

Opportunities and Challenges for Natural Products as Novel Antituberculosis Agents

Farah, S. I., Abdelrahman, A. A., North, E. J. & Chauhan, H., Jan 1 2016, In : Assay and Drug Development Technologies. 14, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

Biological Products
Tuberculosis
Physical Chemistry
Chalcones
Polyketides
34 Citations (Scopus)

Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3

Li, W., Obregón-Henao, A., Wallach, J. B., North, E. J., Lee, R. E., Gonzalez-Juarrero, M., Schnappinger, D. & Jackson, M., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

Mycolic Acids
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
Bacterial Load
Infection
2014
12 Citations (Scopus)

A screen for and validation of prodrug antimicrobials

Fleck, L. E., North, E. J., Lee, R. E., Mulcahy, L. R., Casadei, G. & Lewis, K., Mar 2014, In : Antimicrobial Agents and Chemotherapy. 58, 3, p. 1410-1419 10 p.

Research output: Contribution to journalArticle

Prodrugs
Biofilms
Anti-Bacterial Agents
Nitroreductases
Nitrofurans
2 Citations (Scopus)

In vitro and in vivo activities of hpi1, a selective antimicrobial against helicobacter pylori

Gavrish, E., Shrestha, B., Chen, C., Lister, I., North, E. J., Yang, L., Lee, R. E., Han, A., Williams, B., Charnuska, D., Coleman, K., Lewis, K. & LaFleura, M. D., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 6, p. 3255-3260 6 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Helicobacter Infections
Bismuth
Proton Pump Inhibitors
Peptic Ulcer
88 Citations (Scopus)

Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

Li, W., Upadhyay, A., Fontes, F. L., North, E. J., Wang, Y., Crans, D. C., Grzegorzewicz, A. E., Jones, V., Franzblau, S. G., Lee, R. E., Crick, D. C. & Jackson, M., Nov 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 11, p. 6413-6423 11 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Mycolic Acids
Bacillus
Periplasm
Membranes
2013
43 Citations (Scopus)

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3- heteroaryl ureas with improved in vitro pharmacokinetic properties

North, E. J., Scherman, M. S., Bruhn, D. F., Scarborough, J. S., Maddox, M. M., Jones, V., Grzegorzewicz, A., Yang, L., Hess, T., Morisseau, C., Jackson, M., McNeil, M. R. & Lee, R. E., May 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2587-2599 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Oxadiazoles
Isoxazoles
Urea
Epoxide Hydrolases
20 Citations (Scopus)

Potentiation of azole antifungals by 2-adamantanamine

LaFleur, M. D., Sun, L., Lister, I., Keating, J., Nantel, A., Long, L., Ghannoum, M., North, E. J., Lee, R. E., Coleman, K., Dahl, T. & Lewis, K., Aug 2013, In : Antimicrobial Agents and Chemotherapy. 57, 8, p. 3585-3592 8 p.

Research output: Contribution to journalArticle

Azoles
Ergosterol
Fluconazole
Candidiasis
Biofilms
2012
205 Citations (Scopus)

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Grzegorzewicz, A. E., Pham, H., Gundi, V. A. K. B., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E. M., Korduláková, J., Chavadi, S. S., Morisseau, C., Lenaerts, A. J., Lee, R. E., McNeil, M. R. & Jackson, M., Apr 2012, In : Nature Chemical Biology. 8, 4, p. 334-341 8 p.

Research output: Contribution to journalArticle

Mycolic Acids
Mycobacterium tuberculosis
Cell Membrane
Multidrug-Resistant Tuberculosis
Trehalose
51 Citations (Scopus)

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

Scherman, M. S., North, E. J., Jones, V., Hess, T. N., Grzegorzewicz, A. E., Kasagami, T., Kim, I. H., Merzlikin, O., Lenaerts, A. J., Lee, R. E., Jackson, M., Morisseau, C. & McNeil, M. R., May 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 10, p. 3255-3262 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Mycobacterium tuberculosis
Chemical properties
Biological Availability
Libraries
2011
60 Citations (Scopus)

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

Brown, J. R., North, E. J., Hurdle, J. G., Morisseau, C., Scarborough, J. S., Sun, D., Korduláková, J., Scherman, M. S., Jones, V., Grzegorzewicz, A., Crew, R. M., Jackson, M., McNeil, M. R. & Lee, R. E., Sep 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 18, p. 5585-5595 11 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Structure-Activity Relationship
Urea
Tuberculosis
Derivatives
2010
26 Citations (Scopus)

Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors

North, E. J., Howard, A. L., Wanjala, I. W., Pham, T. C. T., Baker, D. L. & Parrill, A. L., Apr 22 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3095-3105 11 p.

Research output: Contribution to journalArticle

Chemical Databases
Lysophosphatidylcholines
Inhibitory Concentration 50
Glycoproteins
Cardiovascular Diseases
2009
22 Citations (Scopus)

Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs

North, E. J., Osborne, D. A., Bridson, P. K., Baker, D. L. & Parrill, A. L., May 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 9, p. 3433-3442 10 p.

Research output: Contribution to journalArticle

Lysophosphatidylcholines
Structure-Activity Relationship
Choline
Substrates
Catalytic Domain
2008
24 Citations (Scopus)

Molecular recognition in the sphingosine 1-phosphate receptor family

Pham, T. C. T., Fells, J. I., Osborne, D. A., North, E. J., Naor, M. M. & Parrill, A. L., Jun 2008, In : Journal of Molecular Graphics and Modelling. 26, 8, p. 1189-1201 13 p.

Research output: Contribution to journalArticle

Sphingosines
Lysosphingolipid Receptors
Molecular recognition
phosphates
Phosphates