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Research Output 1995 2019

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Article
2018
4 Citations (Scopus)

A mouse model of MIR-96, MIR-182 and MIR-183 misexpression implicates MIRNAs in cochlear cell fate and homeostasis

Weston, M., Tarang, S., Pierce, M. L., Pyakurel, U., Rocha-Sanchez, S., McGee, J. A., Walsh, E. J. & Soukup, G., Dec 1 2018, In : Scientific Reports. 8, 1, 3569.

Research output: Contribution to journalArticle

Cochlea
MicroRNAs
Homeostasis
Inner Auditory Hair Cells
Homozygote
2017
4 Citations (Scopus)

Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells

Ebeid, M., Sripal, P., Pecka, J., Beisel, K., Kwan, K. & Soukup, G., Jul 1 2017, In : PLoS One. 12, 7, e0180855.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Transcriptome
transcriptome
Ear
2014
74 Citations (Scopus)

Characterization of transcriptomes of cochlear inner and outer hair cells

Liu, H., Pecka, J. L., Zhang, Q., Soukup, G., Beisel, K. & He, D. Z., 2014, In : Journal of Neuroscience. 34, 33, p. 11085-11095 11 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Inner Auditory Hair Cells
Transcriptome
Genes
Cochlea
5 Citations (Scopus)

Conditional and target-specific transgene induction through RNA replacement using an allosteric trans-splicing ribozyme

Kim, J., Jeong, S., Kertsburg, A., Soukup, G. & Lee, S. W., Nov 21 2014, In : ACS Chemical Biology. 9, 11, p. 2491-2495 5 p.

Research output: Contribution to journalArticle

Trans-Splicing
Catalytic RNA
Transgenes
RNA
Theophylline
5 Citations (Scopus)

Identifying MicroRNAs involved in aging of the lateral wall of the cochlear duct

Zhang, Q., Liu, H., Soukup, G. & He, D. Z., Nov 18 2014, In : PLoS One. 9, 11, 0112857.

Research output: Contribution to journalArticle

Cochlear Duct
MicroRNAs
microRNA
Ducts
Aging of materials
2013
40 Citations (Scopus)

Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss

Zhang, Q., Liu, H., McGee, J. A., Walsh, E. J., Soukup, G. & He, D. Z., Apr 30 2013, In : PLoS One. 8, 4, e62786.

Research output: Contribution to journalArticle

Organ of Corti
Audition
hearing
MicroRNAs
microRNA
2012
12 Citations (Scopus)

Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development

Barritt, L. C., Miller, J. M., Scheetz, L. R., Gardner, K., Pierce, M. L., Soukup, G. & Rocha-Sanchez, S., Sep 2012, In : Indian Journal of Human Genetics. 18, 3, p. 310-319 10 p.

Research output: Contribution to journalArticle

Genes
MicroRNAs
Cell Survival
Branchial Region
Physiologic Calcification
2011
74 Citations (Scopus)

MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival

Weston, M., Pierce, M. L., Jensen-Smith, H. C., Fritzsch, B., Rocha-Sanchez, S., Beisel, K. & Soukup, G., Apr 2011, In : Developmental Dynamics. 240, 4, p. 808-819 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Cell Survival
Maintenance
Inner Ear
Auditory Hair Cells
31 Citations (Scopus)

MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection

Gong, A. Y., Hu, G., Zhou, R., Liu, J., Feng, Y., Soukup, G. & Chen, X-M., 2011, In : International Journal for Parasitology. 41, 3, p. 397-403 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Intercellular Adhesion Molecule-1
MicroRNAs
Epithelial Cells
Infection
47 Citations (Scopus)

The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss

Kersigo, J., D'Angelo, A., Gray, B. D., Soukup, G. & Fritzsch, B., Apr 2011, In : Genesis. 49, 4, p. 326-341 16 p.

Research output: Contribution to journalArticle

Prosencephalon
MicroRNAs
Ear
Telencephalon
Cerebellum
2010
18 Citations (Scopus)

Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding

Klawuhn, K., Jansen, J. A., Souchek, J., Soukup, G. & Strauss-Soukup, J. K., Dec 10 2010, In : ChemBioChem. 11, 18, p. 2567-2571 5 p.

Research output: Contribution to journalArticle

Catalytic RNA
Coenzymes
Metal ions
Metals
Ions
2009
3 Citations (Scopus)
Riboswitch
Nucleotides
RNA
RNA Folding
Gene Expression
128 Citations (Scopus)

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes

Gong, A. Y., Zhou, R., Hu, G., Li, X., Splinter, P. L., O'Hara, S. P., LaRusso, N. F., Soukup, G., Dong, H. & Chen, X-M., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

MicroRNAs
3' Untranslated Regions
Transfection
Proteins
B7 Antigens
93 Citations (Scopus)

Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

Soukup, G., Fritzsch, B., Pierce, M. L., Weston, M., Jahan, I., McManus, M. T. & Harfe, B. D., Apr 15 2009, In : Developmental Biology. 328, 2, p. 328-341 14 p.

Research output: Contribution to journalArticle

Inner Ear
MicroRNAs
Knockout Mice
Epithelium
Stereocilia
2008
114 Citations (Scopus)

MicroRNA-183 family conservation and ciliated neurosensory organ expression

Pierce, M. L., Weston, M., Fritzsch, B., Gabel, H. W., Ruvkun, G. & Soukup, G., Jan 2008, In : Evolution and Development. 10, 1, p. 106-113 8 p.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
metazoan
hair
Genome Components
2006
49 Citations (Scopus)

Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme

Jansen, J. A., McCarthy, T. J., Soukup, G. & Strauss-Soukup, J. K., Jun 26 2006, In : Nature Structural and Molecular Biology. 13, 6, p. 517-523 7 p.

Research output: Contribution to journalArticle

Catalytic RNA
Ligands
Nucleotides
Riboswitch
Amino Sugars
25 Citations (Scopus)

Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure

Soukup, G., 2006, In : Nucleic Acids Research. 34, 3, p. 968-975 8 p.

Research output: Contribution to journalArticle

Catalytic RNA
Conserved Sequence
Catalytic Domain
Riboswitch
5' Untranslated Regions
150 Citations (Scopus)

MicroRNA gene expression in the mouse inner ear

Weston, M., Pierce, M. L., Rocha-Sanchez, S., Beisel, K. & Soukup, G., Sep 21 2006, In : Brain Research. 1111, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

Inner Ear
MicroRNAs
Gene Expression
Auditory Hair Cells
Vestibular Hair Cells
2005
103 Citations (Scopus)

Ligand requirements for glmS ribozyme self-cleavage

McCarthy, T. J., Plog, M. A., Floy, S. A., Jansen, J. A., Strauss-Soukup, J. K. & Soukup, G., Nov 2005, In : Chemistry and Biology. 12, 11, p. 1221-1226 6 p.

Research output: Contribution to journalArticle

Catalytic RNA
Catalysis
RNA
Ligands
Coenzymes
2002
45 Citations (Scopus)

A versatile communication module for controlling RNA folding and catalysis

Kertsburg, A. & Soukup, G., Nov 1 2002, In : Nucleic Acids Research. 30, 21, p. 4599-4606 8 p.

Research output: Contribution to journalArticle

RNA Folding
Catalysis
RNA
Hepatitis Delta Virus
Ligands
2001
70 Citations (Scopus)

Cooperative binding of effectors by an allosteric ribozyme

Jose, A. M., Soukup, G. & Breaker, R. R., Apr 1 2001, In : Nucleic Acids Research. 29, 7, p. 1631-1637 7 p.

Research output: Contribution to journalArticle

Catalytic RNA
Flavin Mononucleotide
RNA
Theophylline
Catalysis
60 Citations (Scopus)

Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes

Soukup, G., Derose, E. C., Koizumi, M. & Breaker, R. R., 2001, In : RNA. 7, 4, p. 524-536 13 p.

Research output: Contribution to journalArticle

Catalytic RNA
RNA
Ligands
Cyclic Nucleotides
Mutagenesis
2000
90 Citations (Scopus)

Altering molecular recognition of RNA aptamers by allosteric selection

Soukup, G., Emilsson, G. A. M. & Breaker, R. R., May 12 2000, In : Journal of Molecular Biology. 298, 4, p. 623-632 10 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Catalytic RNA
Theophylline
Catalysis
Nucleic Acids
1999
11 Citations (Scopus)

Allosteric ribozymes sensitive to the second messengers cAMP and cGMP.

Koizumi, M., Kerr, J. N., Soukup, G. & Breaker, R. R., 1999, In : Nucleic acids symposium series. 42, p. 275-276 2 p.

Research output: Contribution to journalArticle

Catalytic RNA
Second Messenger Systems
Nucleosides
Binding Sites
Ligands
151 Citations (Scopus)

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP

Koizumi, M., Soukup, G., Kerr, J. N. Q. & Breaker, R. R., 1999, In : Nature Structural Biology. 6, 11, p. 1062-1071 10 p.

Research output: Contribution to journalArticle

Catalytic RNA
Second Messenger Systems
RNA
Molecular recognition
Structural dynamics
72 Citations (Scopus)

Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization

Soukup, G. & Breaker, R. R., Jul 15 1999, In : Structure. 7, 7, p. 783-791 9 p.

Research output: Contribution to journalArticle

Catalytic RNA
Ligands
Flavin Mononucleotide
Theophylline
Catalytic Domain
262 Citations (Scopus)

Engineering precision RNA molecular switches

Soukup, G. & Breaker, R. R., Mar 30 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3584-3589 6 p.

Research output: Contribution to journalArticle

RNA
Ligands
Catalytic RNA
Catalytic Domain
Enzymes
122 Citations (Scopus)

Nucleic acid molecular switches

Soukup, G. & Breaker, R. R., Dec 1 1999, In : Trends in Biotechnology. 17, 12, p. 469-476 8 p.

Research output: Contribution to journalArticle

Catalytic RNA
Nucleic acids
Nucleic Acids
Switches
Nanotechnology
388 Citations (Scopus)

Relationship between internucleotide linkage geometry and the stability of RNA

Soukup, G. & Breaker, R. R., Oct 1999, In : RNA. 5, 10, p. 1308-1325 18 p.

Research output: Contribution to journalArticle

RNA Cleavage
RNA Stability
Nucleotide Aptamers
Catalytic RNA
Ribonucleases
1998
7 Citations (Scopus)

Selection and characterization of RNAs that relieve transcriptional interference in Escherichia coli

Soukup, G. & Maher, L. J., Jun 1 1998, In : Nucleic Acids Research. 26, 11, p. 2715-2722 8 p.

Research output: Contribution to journalArticle

RNA
Escherichia coli
DNA
Oligonucleotides
Genes
1996
22 Citations (Scopus)

Selection of RNAs that bind to duplex DNA at neutral pH

Soukup, G., Ellington, A. D. & Maher, L. J., Jun 7 1996, In : Journal of Molecular Biology. 259, 2, p. 216-228 13 p.

Research output: Contribution to journalArticle

RNA
DNA
Oligonucleotides
DNA-Directed RNA Polymerases
Genetic Therapy
1995
16 Citations (Scopus)

Preparation of oligonucleotide-biotin conjugates with cleavable linkers

Soukup, G., Cerny, R. L. & Maher, L. J., 1995, In : Bioconjugate Chemistry. 6, 1, p. 135-138 4 p.

Research output: Contribution to journalArticle

Oligonucleotides
Biotin
Dithiothreitol
Disulfides
Amines