• 1109 Citations
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1988 …2019
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Research Output 1993 2019

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Article
2019
4 Citations (Scopus)

Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demise

Desa, D. E., Nichols, M. G. & Smith, H. J., May 1 2019, In : Journal of Biomedical Optics. 24, 5, 051403.

Research output: Contribution to journalArticle

nicotinamide
antibiotics
adenines
Aminoglycosides
metabolism
Paclitaxel
Lipids
Light
Ascorbic Acid
Lighting
2016
1 Citation (Scopus)

Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis

Prathivadhi-Bhayankaram, S. V., Ning, J., Mimlitz, M., Taylor, C., Gross, E. M., Nichols, M. G., Guck, J. & Ekpenyong, A., Oct 28 2016, In : Biochemical and Biophysical Research Communications. 479, 4, p. 841-846 6 p.

Research output: Contribution to journalArticle

Microcirculation
Chemotherapy
Cell Movement
Cells
Neoplasm Metastasis
2015
7 Citations (Scopus)

Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging

Zholudeva, L. V., Ward, K. G., Nichols, M. G. & Smith, H. J., May 1 2015, In : Journal of Biomedical Optics. 20, 5, 051032.

Research output: Contribution to journalArticle

hair
metabolism
Antibiotics
Gentamicins
Metabolism
2013
7 Citations (Scopus)

The conserved tetrameric subunit stoichiometry of Slc26 proteins

Hallworth, R. J., Stark, K., Zholudeva, L., Currall, B. B. & Nichols, M. G., Aug 2013, In : Microscopy and Microanalysis. 19, 4, p. 799-807 9 p.

Research output: Contribution to journalArticle

Stoichiometry
stoichiometry
proteins
Proteins
vertebrates
2012
27 Citations (Scopus)

Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells

Jensen-Smith, H. C., Hallworth, R. J. & Nichols, M. G., Jun 8 2012, In : PLoS One. 7, 6, e38471.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Inner Auditory Hair Cells
gentamicin
Gentamicins
Metabolism
27 Citations (Scopus)

Metabolic imaging using two-photon excited nadh intensity and fluorescence lifetime imaging

Vergen, J., Hecht, C., Zholudeva, L. V., Marquardt, M. M., Hallworth, R. J. & Nichols, M. G., Aug 2012, In : Microscopy and Microanalysis. 18, 4, p. 761-770 10 p.

Research output: Contribution to journalArticle

Photons
Fluorescence
Imaging techniques
life (durability)
fluorescence
23 Citations (Scopus)

Prestin in HEK cells is an obligate tetramer

Hallworth, R. J. & Nichols, M. G., Jan 2012, In : Journal of Neurophysiology. 107, 1, p. 5-11 7 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Plasmids
Cyclic Nucleotide-Gated Cation Channels
Membranes
Statistical Models
7 Citations (Scopus)

The single molecule imaging approach to membrane protein stoichiometry

Hallworth, R. J. & Nichols, M. G., Aug 2012, In : Microscopy and Microanalysis. 18, 4, p. 771-780 10 p.

Research output: Contribution to journalArticle

Stoichiometry
stoichiometry
membranes
proteins
Proteins
2010
14 Citations (Scopus)

Photo- and bio-physical characterization of novel violet and near-infrared lipophilic fluorophores for neuronal tracing

Tonniges, J., Hansen, M., Duncan, J., Bassett, M. J., Fritzsch, B., Gray, B. D., Easwaran, A. & Nichols, M. G., 2010, In : Journal of Microscopy. 239, 2, p. 117-134 18 p.

Research output: Contribution to journalArticle

Coloring Agents
Photons
Fluorescence Recovery After Photobleaching
Neurons
Aluminum Oxide
2009
18 Citations (Scopus)

Determination of cell elasticity through hybrid ray optics and continuum mechanics modeling of cell deformation in the optical stretcher

Ekpenyong, A., Posey, C. L., Chaput, J. L., Burkart, A. K., Marquardt, M. M., Smith, T. J. & Nichols, M. G., Nov 10 2009, In : Applied Optics. 48, 32, p. 6344-6354 11 p.

Research output: Contribution to journalArticle

continuum mechanics
Continuum mechanics
geometrical optics
Elasticity
Optics
19 Citations (Scopus)

Metabolic imaging of the organ of corti - A window on cochlea bioenergetics

Tiede, L. A., Steyger, P. S., Nichols, M. G. & Hallworth, R. J., Jun 24 2009, In : Brain Research. 1277, p. 37-41 5 p.

Research output: Contribution to journalArticle

Organ of Corti
Cochlea
Energy Metabolism
NAD
Alopecia
2007
28 Citations (Scopus)

Determination of hair cell metabolic state in isolated cochlear preparations by two-photon microscopy

Tiede, L. M., Rocha-Sanchez, S., Hallworth, R. J., Nichols, M. G. & Beisel, K., Mar 2007, In : Journal of Biomedical Optics. 12, 2, 021004.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Inner Auditory Hair Cells
Cochlea
hair
Photons
2006
15 Citations (Scopus)

Near-infrared laser illumination transforms the fluorescence absorbing X-Gal reaction product BCI into a transparent, yet brightly fluorescent substance

Matei, V. A., Feng, F., Pauley, S., Beisel, K., Nichols, M. G. & Fritzsch, B., Jun 15 2006, In : Brain Research Bulletin. 70, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

Galactosidases
Lighting
Lasers
Fluorescence
Light
24 Citations (Scopus)
Photobleaching
nicotinamide
leukemias
adenines
NAD
2005
5 Citations (Scopus)

A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells

Barth, E. E., Hallworth, R. J. & Nichols, M. G., May 2005, In : Photochemistry and Photobiology. 81, 3, p. 556-562 7 p.

Research output: Contribution to journalArticle

leukemias
Bromodeoxyuridine
rats
Rats
Assays
15 Citations (Scopus)

Reduction in DNA synthesis during two-photon microscopy of intrinsic reduced nicotinamide adenine dinucleotide fluorescence

Nichols, M. G., Barth, E. E. & Nichols, J. A., Mar 2005, In : Photochemistry and Photobiology. 81, 2, p. 259-269 11 p.

Research output: Contribution to journalArticle

nicotinamide
adenines
Photons
NAD
Microscopy
2001
13 Citations (Scopus)

Retrofitted confocal laser scanner for a commercial inverted fluorescence microscope

Bigelow, C. E., Harkrider, C. J., Conover, D. L., Foster, T. H., Georgakoudi, I., Mitra, S., Nichols, M. G. & Rajadhyaksha, M., Aug 2001, In : Review of Scientific Instruments. 72, 8, p. 3407-3410 4 p.

Research output: Contribution to journalArticle

scanners
Microscopes
Fluorescence
microscopes
fluorescence
2000
68 Citations (Scopus)

Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of autologous bone marrow grafts from residual tumor cells

Indig, G. L., Anderson, G. S., Nichols, M. G., Bartlett, J. A., Mellon, W. S. & Sieber, F., Jan 2000, In : Journal of Pharmaceutical Sciences. 89, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

Bone Marrow Purging
Purging
Residual Neoplasm
Molecular Structure
Gentian Violet
1998
59 Citations (Scopus)

Localization of luminescent inhomogeneities in turbid media with spatially resolved measurements of cw diffuse luminescence emittance

Hull, E. L., Nichols, M. G. & Foster, T. H., 1998, In : Applied Optics. 37, 13, p. 2755-2765 11 p.

Research output: Contribution to journalArticle

Phosphorescence
Fluorophores
Surface measurement
emittance
Light sources
84 Citations (Scopus)

Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes

Hull, E. L., Nichols, M. G. & Foster, T. H., Nov 1998, In : Physics in Medicine and Biology. 43, 11, p. 3381-3404 24 p.

Research output: Contribution to journalArticle

Near infrared spectroscopy
Near-Infrared Spectroscopy
hemoglobin
erythrocytes
Absorption spectra
1997
162 Citations (Scopus)

Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems

Nichols, M. G., Hull, E. L. & Foster, T. H., Jan 1 1997, In : Applied Optics. 36, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Spectrometers
Optical properties
Scattering
spectrometers
Tissue
201 Citations (Scopus)

The mechanism of Photofrin photobleaching and its consequences for photodynamic dosimetry

Georgakoudi, I., Nichols, M. G. & Foster, T. H., Jan 1997, In : Photochemistry and Photobiology. 65, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

Dihematoporphyrin Ether
Photobleaching
Singlet Oxygen
bleaching
Bleaching
5 Citations (Scopus)

Two steady-state methods for localizing a fluorescent inhomogeneity in a turbid medium

Foster, T. H., Hull, E. L., Nichols, M. G., Rifkin, D. S. & Schwartz, N., 1997, In : Unknown Journal. 2979, p. 741-749 9 p.

Research output: Contribution to journalArticle

inhomogeneity
Fluorescence
fluorescence
Scattering
pencil beams
1994
102 Citations (Scopus)

Oxygen diffusion and reaction kinetics in the photodynamic therapy of multicell tumour spheroids

Nichols, M. G. & Foster, T. H., 1994, In : Physics in Medicine and Biology. 39, 12, p. 2161-2181 21 p., 003.

Research output: Contribution to journalArticle

Photodynamic therapy
spheroids
Photochemotherapy
Reaction kinetics
Tumors
1993
146 Citations (Scopus)

Fluence Rate Effects in Photodynamic Therapy of Multicell Tumor Spheroids

Foster, T. H., Hartley, D. F., Nichols, M. G. & Hilf, R., 1993, In : Cancer Research. 53, 6, p. 1249-1254 6 p.

Research output: Contribution to journalArticle

Photochemotherapy
Oxygen Consumption
Neoplasms
Dihematoporphyrin Ether
Radiation