• 435 Citations
  • 14 h-Index
1984 …2014
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

External positions

Emory University

Max Planck Institute for Experimental Medicine

Salk Institute for Biological Studies

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Proinsulin Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Proglucagon Medicine & Life Sciences
Secretory Vesicles Medicine & Life Sciences
Purification Chemical Compounds
Proprotein Convertase 2 Medicine & Life Sciences
Carboxypeptidase B Medicine & Life Sciences
Peptides Medicine & Life Sciences

Research Output 1984 2014

  • 435 Citations
  • 14 h-Index
  • 26 Article
  • 1 Review article
Proinsulin
Inclusion Bodies
Impurities
Purification
divinyl benzene
2 Citations

Epidemiology and clinical diagnosis: Alzheimer disease

Mackin, R., Oct 2013, In : PET Clinics. 8, 4, p. 391-405 15 p.

Research output: Contribution to journalArticle

epidemiology
Dementia
impairment
Alzheimer Disease
Epidemiology
28 Citations

An Achilles' heel in an amyloidogenic protein and its repair: Insulin fibrillation and therapeutic design

Yang, Y., Petkova, A., Huang, K., Xu, B., Hua, Q. X., Ye, I. J., Chu, Y. C., Hu, S. Q., Phillips, N. B., Whittaker, J., Ismail-Beigi, F., Mackin, R., Katsoyannis, P. G., Tycko, R. & Weiss, M. A., Apr 2 2010, In : Journal of Biological Chemistry. 285, 14, p. 10806-10821 16 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Repair
Insulin
Chemical shift
Substitution reactions
33 Citations

Solution structure of proinsulin: Connecting domain flexibility and prohormone processing

Yang, Y., Hua, Q. X., Liu, J., Shimizu, E. H., Choquette, M. H., Mackin, R. & Weiss, M. A., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7847-7851 5 p.

Research output: Contribution to journalArticle

Proinsulin
Insulin
Medical problems
Processing
Diabetes Mellitus
17 Citations

Crystal structure of a "nonfoldable" insulin. Impaired folding efficiency despite native activity

Liu, M., Wan, Z. I., Chu, Y. C., Aladdin, H., Klaproth, B., Choquette, M., Hua, Q. X., Mackin, R., Rao, J. S., De Meyts, P., Katsoyannis, P. G., Arvan, P. & Weiss, M. A., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 35259-35272 14 p.

Research output: Contribution to journalArticle

Proinsulin
Disulfides
Crystal structure
Insulin
Substitution reactions