• 455 Citations
  • 14 h-Index
1984 …2014

Research output per year

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Research Output

  • 455 Citations
  • 14 h-Index
  • 25 Article
  • 2 Review article
Article
1 Scopus citations

An Achilles' heel in an amyloidogenic protein and its repair: Insulin fibrillation and therapeutic design

Yang, Y., Petkova, A., Huang, K., Xu, B., Hua, Q. X., Ye, I. J., Chu, Y. C., Hu, S. Q., Phillips, N. B., Whittaker, J., Ismail-Beigi, F., Mackin, R. B., Katsoyannis, P. G., Tycko, R. & Weiss, M. A., Apr 2 2010, In : Journal of Biological Chemistry. 285, 14, p. 10806-10821 16 p.

Research output: Contribution to journalArticle

31 Scopus citations

Characterization of an islet carboxypeptidase b involved in prohormone processing

Mackin, R. B. & Noe, B. D., Feb 1987, In : Endocrinology. 120, 2, p. 457-468 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Crystal structure of a "nonfoldable" insulin. Impaired folding efficiency despite native activity

Liu, M., Wan, Z. I., Chu, Y. C., Aladdin, H., Klaproth, B., Choquette, M., Hua, Q. X., Mackin, R. B., Rao, J. S., De Meyts, P., Katsoyannis, P. G., Arvan, P. & Weiss, M. A., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 35259-35272 14 p.

Research output: Contribution to journalArticle

18 Scopus citations
18 Scopus citations

Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia

Dhanvantari, S., Shen, F. S., Adams, T., Snell, C. R., Zhang, C., Mackin, R. B., Morris, S. J. & Loh, Y. P., Sep 1 2003, In : Molecular Endocrinology. 17, 9, p. 1856-1867 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: An antisense study

Rothenberg, M. E., Eilertson, C. D., Klein, K., Mackin, R. B. & Noe, B. D., Apr 18 1996, In : Molecular Endocrinology. 10, 4, p. 331-341 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expression, purification, and PC1-mediated processing of (H10D, P28K, and K29P)-human proinsulin

Mackin, R. B. & Choquette, M. H., Feb 1 2003, In : Protein Expression and Purification. 27, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
3 Scopus citations

Expression, purification and characterization of recombinant human proinsulin

Cowley, D. J. & Mackin, R. B., Jan 27 1997, In : FEBS Letters. 402, 2-3, p. 124-130 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family

Mackin, R. B., Noe, B. D. & Spiess, J., Oct 1991, In : Endocrinology. 129, 4, p. 2263-2265 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

Improved method for identification of proteins using two‐dimensional electrophoresis with immobilized pH gradient isoelectric focusing

Mackin, R. B., Raker, V. A. & Spiess, J., 1991, In : ELECTROPHORESIS. 12, 9, p. 678-680 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Islet secretory granules contain cytochrome b561

Mackin, R. B., Jones, D. P. & Noe, B. D., Jan 1 1986, In : Diabetes. 35, 8, p. 881-885 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
19 Scopus citations

Peptidyl-glycine α-amidating monooxygenase is present in islet secretory granules of the anglerfish, Lophius americanus

Mackin, R. B., Flacker, J. M., Mackin, J. A. & Noe, B. D., Aug 1987, In : General and Comparative Endocrinology. 67, 2, p. 263-269 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Primary structure and tissue distribution of anglerfish carboxypeptidase H

Roth, W. W., Mackin, R. B., Spiess, J., Goodman, R. H. & Noe, B. D., Jul 1991, In : Molecular and Cellular Endocrinology. 78, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro

Rothenberg, M. E., Eilertson, C. D., Klein, K., Zhou, Y., Lindberg, I., McDonald, J. K., Mackin, R. B. & Noe, B. D., 1995, In : Journal of Biological Chemistry. 270, 17, p. 10136-10146 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Properties of a carboxypeptidase B-like enzyme believed to be involved in islet prohormone processing

Mackin, R. B. & Noe, B. D., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 5797

Research output: Contribution to journalArticle

Purification of prosomatostatin-converting enzymes

Mackin, R. B., Noe, B. D. & Spiess, J., Sep 1990, In : Metabolism. 39, 9 SUPPL. 2, p. 30-32 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Solution structure of proinsulin: Connecting domain flexibility and prohormone processing

Yang, Y., Hua, Q. X., Liu, J., Shimizu, E. H., Choquette, M. H., Mackin, R. B. & Weiss, M. A., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7847-7851 5 p.

Research output: Contribution to journalArticle

36 Scopus citations
10 Scopus citations

Synthetic small-molecule prohormone convertase 2 inhibitors

Kowalska, D., Liu, J., Appel, J. R., Ozawa, A., Nefzi, A., Mackin, R. B., Houghten, R. A. & Lindberg, I., Mar 1 2009, In : Molecular Pharmacology. 75, 3, p. 617-625 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The anglerfish somatostatin-28-generating propeptide converting enzyme is an aspartyl protease

Mackin, R. B., Spiess, J. & Noe, B. D., Oct 1991, In : Endocrinology. 129, 4, p. 1951-1957 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Total error profiling of a proinsulin time-resolved fluorescence immunoassay

De Pauw, P. E., Mackin, R. B., Goubert, P., Van Schravendijk, C. & Gorus, F. K., Sep 1 2009, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 877, 23, p. 2403-2406 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
Review article

Epidemiology and clinical diagnosis: Alzheimer disease

Robert, M., Oct 2013, In : PET Clinics. 8, 4, p. 391-405 15 p.

Research output: Contribution to journalReview article

2 Scopus citations

Proinsulin: Recent observations and controversies

Mackin, R. B., Aug 28 1998, In : Cellular and Molecular Life Sciences. 54, 7, p. 696-702 7 p.

Research output: Contribution to journalReview article

12 Scopus citations