• 442 Citations
  • 14 h-Index
1984 …2014
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Research Output 1984 2014

  • 442 Citations
  • 14 h-Index
  • 26 Article
  • 1 Review article
Article
Proinsulin
Inclusion Bodies
Impurities
Purification
divinyl benzene
28 Citations (Scopus)

An Achilles' heel in an amyloidogenic protein and its repair: Insulin fibrillation and therapeutic design

Yang, Y., Petkova, A., Huang, K., Xu, B., Hua, Q. X., Ye, I. J., Chu, Y. C., Hu, S. Q., Phillips, N. B., Whittaker, J., Ismail-Beigi, F., Mackin, R., Katsoyannis, P. G., Tycko, R. & Weiss, M. A., Apr 2 2010, In : Journal of Biological Chemistry. 285, 14, p. 10806-10821 16 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Repair
Insulin
Chemical shift
Substitution reactions
21 Citations (Scopus)

Characterization of an islet carboxypeptidase B involved in prohormone processing.

Mackin, R. & Noe, B. D., Feb 1987, In : Endocrinology. 120, 2, p. 457-468 12 p.

Research output: Contribution to journalArticle

Carboxypeptidase B
Enzymes
Secretory Vesicles
Subcellular Fractions
Microsomes
18 Citations (Scopus)

Crystal structure of a "nonfoldable" insulin. Impaired folding efficiency despite native activity

Liu, M., Wan, Z. I., Chu, Y. C., Aladdin, H., Klaproth, B., Choquette, M., Hua, Q. X., Mackin, R., Rao, J. S., De Meyts, P., Katsoyannis, P. G., Arvan, P. & Weiss, M. A., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 35259-35272 14 p.

Research output: Contribution to journalArticle

Proinsulin
Disulfides
Crystal structure
Insulin
Substitution reactions
18 Citations (Scopus)
Somatostatin
Assays
Enzymes
Peptides
Proinsulin
31 Citations (Scopus)

Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia

Dhanvantari, S., Shen, F. S., Adams, T., Snell, C. R., Zhang, C., Mackin, R., Morris, S. J. & Loh, Y. P., Sep 1 2003, In : Molecular Endocrinology. 17, 9, p. 1856-1867 12 p.

Research output: Contribution to journalArticle

Proinsulin
Carboxypeptidase H
Secretory Pathway
Secretory Vesicles
Hyperproinsulinemia
2 Citations (Scopus)

Epidemiology and clinical diagnosis: Alzheimer disease

Mackin, R., Oct 2013, In : PET Clinics. 8, 4, p. 391-405 15 p.

Research output: Contribution to journalArticle

epidemiology
Dementia
impairment
Alzheimer Disease
Epidemiology
28 Citations (Scopus)

Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: An antisense study

Rothenberg, M. E., Eilertson, C. D., Klein, K., Mackin, R. & Noe, B. D., 1996, In : Molecular Endocrinology. 10, 4, p. 331-341 11 p.

Research output: Contribution to journalArticle

Proglucagon
Proprotein Convertases
Glicentin
Peptides
Transfection
14 Citations (Scopus)

Expression, purification, and PC1-mediated processing of (H10D, P28K, and K29P)-human proinsulin

Mackin, R. & Choquette, M. H., Feb 2003, In : Protein Expression and Purification. 27, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Proinsulin
Purification
Processing
Inclusion Bodies
Reverse-Phase Chromatography
2 Citations (Scopus)
Glicentin
Proglucagon
Purification
Processing
Furin
53 Citations (Scopus)

Expression, purification and characterization of recombinant human proinsulin

Cowley, D. J. & Mackin, R., Jan 27 1997, In : FEBS Letters. 402, 2-3, p. 124-130 7 p.

Research output: Contribution to journalArticle

Proinsulin
Purification
Furin
Cyanogen Bromide
Peptides
24 Citations (Scopus)

Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family

Mackin, R., Noe, B. D. & Spiess, J., Oct 1991, In : Endocrinology. 129, 4, p. 2263-2265 3 p.

Research output: Contribution to journalArticle

Furin
Enzymes
Basic Amino Acids
Protein Sequence Analysis
Somatostatin
1 Citation (Scopus)

Improved method for identification of proteins using two-dimensional electrophoresis with immobilized pH gradient isoelectric focusing

Mackin, R., Raker, V. A. & Spiess, J., 1991, In : Electrophoresis. 12, 9, p. 678-680 3 p.

Research output: Contribution to journalArticle

pH
Proton-Motive Force
Electrophoresis, Gel, Two-Dimensional
Isoelectric Focusing
Electrophoresis
7 Citations (Scopus)

Islet secretory granules contain cytochrome b561

Mackin, R., Jones, D. P. & Noe, B. D., 1986, In : Diabetes. 35, 8, p. 881-885 5 p.

Research output: Contribution to journalArticle

Secretory Vesicles
Cytochromes
Dithionite
Succinic Acid
Mixed Function Oxygenases
19 Citations (Scopus)
Tyrosine Transaminase
Organ Specificity
Aspartate Aminotransferases
Glucocorticoids
Isoenzymes
10 Citations (Scopus)

Peptidyl-glycine α-amidating monooxygenase is present in islet secretory granules of the anglerfish, Lophius americanus

Mackin, R., Flacker, J. M., Mackin, J. A. & Noe, B. D., 1987, In : General and Comparative Endocrinology. 67, 2, p. 263-269 7 p.

Research output: Contribution to journalArticle

Lophius americanus
secretory granules
Secretory Vesicles
Mixed Function Oxygenases
Glycine
13 Citations (Scopus)

Primary structure and tissue distribution of anglerfish carboxypeptidase H

Roth, W. W., Mackin, R., Spiess, J., Goodman, R. H. & Noe, B. D., 1991, In : Molecular and Cellular Endocrinology. 78, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

Carboxypeptidase H
Tissue Distribution
Tissue
Fish
Fishes
58 Citations (Scopus)

Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro

Rothenberg, M. E., Eilertson, C. D., Klein, K., Zhou, Y., Lindberg, I., McDonald, J. K., Mackin, R. & Noe, B. D., 1995, In : Journal of Biological Chemistry. 270, 17, p. 10136-10146 11 p.

Research output: Contribution to journalArticle

Proprotein Convertase 2
Proprotein Convertase 1
Proglucagon
Processing
Glucagon
Carboxypeptidase B
Enzymes
2 Citations (Scopus)

Purification of prosomatostatin-converting enzymes

Mackin, R., Noe, B. D. & Spiess, J., 1990, In : Metabolism: Clinical and Experimental. 39, 9 SUPPL. 2, p. 30-32 3 p.

Research output: Contribution to journalArticle

Basic Amino Acids
Diamino Amino Acids
Enzymes
Somatostatin
prosomatostatin
33 Citations (Scopus)

Solution structure of proinsulin: Connecting domain flexibility and prohormone processing

Yang, Y., Hua, Q. X., Liu, J., Shimizu, E. H., Choquette, M. H., Mackin, R. & Weiss, M. A., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 7847-7851 5 p.

Research output: Contribution to journalArticle

Proinsulin
Insulin
Medical problems
Processing
Diabetes Mellitus
10 Citations (Scopus)
Proinsulin
Fusion reactions
Furin
Affinity chromatography
Peptides
16 Citations (Scopus)

Synthetic small-molecule prohormone convertase 2 inhibitors

Kowalska, D., Liu, J., Appel, J. R., Ozawa, A., Nefzi, A., Mackin, R., Houghten, R. A. & Lindberg, I., Mar 2009, In : Molecular Pharmacology. 75, 3, p. 617-625 9 p.

Research output: Contribution to journalArticle

Proprotein Convertase 2
Piperazines
Guanidines
Proprotein Convertase 1
Furin
18 Citations (Scopus)

The anglerfish somatostatin-28-generating propeptide converting enzyme is an aspartyl protease

Mackin, R., Noe, B. D. & Spiess, J., Oct 1991, In : Endocrinology. 129, 4, p. 1951-1957 7 p.

Research output: Contribution to journalArticle

Somatostatin-28
Aspartic Acid Proteases
Enzymes
Secretory Vesicles
Protein Sequence Analysis
proinsulin
Proinsulin
peptides
Peptides
Substrates
5 Citations (Scopus)

Total error profiling of a proinsulin time-resolved fluorescence immunoassay

De Pauw, P. E., Mackin, R., Goubert, P., Van Schravendijk, C. & Gorus, F. K., Sep 1 2009, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 877, 23, p. 2403-2406 4 p.

Research output: Contribution to journalArticle

Proinsulin
Immunoassay
Assays
Immunosorbents
Fluorescence
Review article
11 Citations (Scopus)

Proinsulin: Recent observations and controversies

Mackin, R., 1998, In : Cellular and Molecular Life Sciences. 54, 7, p. 696-702 7 p.

Research output: Contribution to journalReview article

Proinsulin
Peptide Hormones
Insulin
C-Peptide
Medical problems