Project Details
Description
Parkinson’s disease (PD) and Lewy Body Dementia (LBD) incidence is high among the aged
population and mutations in the GBA gene represent one of the most common genetic risk factors for PD and
LBD. Mutations in GBA leading to PD and LBD lead to a reduction in GCase activity, and GCase activity is also
significantly decreased in the substantia nigra and anterior cingulate cortex in sporadic PD and LBD cases,
suggesting a critical role for GCase activity in the pathophysiology of PD and LBD. Identifying upstream
regulators of GBA to control glucosylceramide metabolism may suppress PD and LBD in patients with
mutations in GBA or have reduced GCase activity.
Status | Finished |
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Effective start/end date | 1/15/21 → 12/31/22 |
Funding
- National Institute on Aging: $145,500.00
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