Project: Research project

Project Details


Two hundred healthy women between ages 20 and 25 will be recruited from the
first year classes in the Creighton University Schools of Medicine,
Dentistry and Law. Each will be observed for a period of four years in
order to test the hypothesis that calcium intake measurably influences the
peak adult bone mass achieved after cessation of growth. The effect of
other nutrients such as protein, phosphorus, alcohol and caffeine on this
consolidation of bone mass will also be tested along with the effect of
various self-chosen levels of physical activity. Dietary evaluations will
be made at three-month intervals throughout the study and bone mass
measurements by radio-grammetry, single photon absorptiometry and dual
photon absorptiometry will be made at six-month intervals. Physical
activity will be measured at six-month intervals using an activity monitor
worn on the wrist for a seven-day period. We hope to confirm the findings
of other studies of increased bone mass occurring after cessation of linear
growth and to define the determinants of this increased mass. Thus, we
hope to be able to show that peak skeletal mass is influenced by
non-genetic factors, amenable to intervention early in life in a manner
that can result in higher skeletal mass prior at the time when age-related
bone loss begins at about age 40. This could result in greater skeletal
mass remaining in old age and could offer protection from the crippling
fractures of postmenopausal osteoporosis which afflicts nearly one half of
our Caucasian women in their later years.
Effective start/end date6/1/8411/30/90


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $97,451.00
  • National Institutes of Health


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