EFFICACY TRIAL OF CALCIUM IN FRACTURE PREVENTION

Project: Research project

Description

DESCRIPTION: The purpose of this
application is to request funds for continuation of a prospective,
randomized, double-blind, placebo-controlled study of the efficacy of
increased calcium intake in the prevention of spine fractures and bone loss
in elderly women. Funding for this study began in June of 1987 by the
National Dairy Promotion and Research Board and the National Dairy Council
and is committed until December 31, 1990. Application for renewal for
1991-1993 was scheduled for submission in June 1990. The NDC
administrators have stated that there may not be sufficient funds to
continue it and they have requested that funds be sought elsewhere for
completion of the study. The hypothesis to be tested in the project is
that spine fractures and bone loss in elderly women with low calcium
intakes can be reduced by adding 1200 mg.day of calcium as carbonate to the
diet. The specific aims are: to continue a study of 223 women over the
age of 60; to continue performing annual spine radiographs under standard
conditions on each subject; to continue monitoring the clinical history of
appendicular fracture; to continue performing semiannual measurements of
bone mineral content of the forearm; to continue performing measurements of
serum levels of 25-hydroxy vitamin D on a subset of 50 subjects; and to
continue administration of placebo or calcium, 1200 mg/day, as calcium as
carbonate to randomly chosen subjects in a double blind design, The
principle endpoints will be vertebral deformity by strictly defined
morphometric criteria and forearm bone mineral density. Appendicular
fractures will be monitored and may also accumulate to a sufficient number
to become an endpoint.
StatusFinished
Effective start/end date4/1/913/31/94

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $197,912.00

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Financial Management
Spine
Bone Fractures
Calcium
Forearm
Placebos
Calcium Carbonate
Vitamin D
Bone Density
Minerals
Research