MORPHOLOGIC FINDINGS IN MITRAL VALVE PROLAPSE

Project: Research project

Description

Clinical and necropsy findings are described in 56 patients
with mitral valve prolapse (MVP): 15 patients, aged 16 to 69 years (mean
39), died suddenly and MVP was the only cardiac condition found at
necropsy (hereafter called isolated MVP); the remaining 41 patients had
other conditions that were capable of being fatal. Of the latter 41
patients had other conditions that were capable of being fatal. Of the
latter 41 patients, 7 aged 17 to 59 years (mean 45), had associated
congenital heart disease, and 34 patients, aged 17 to 70 years (mean 52),
had no associated congenital cardiac abnormalities. Compared with the 34 patients without associated congenital
heart disease and with non-MVP conditions capable in themselves of being
fatal, the 15 patients who died suddenly with isolated MVP were younger
(mean age 39 +/- 17 versus 52 +/- 15 years; p = 0.01), more often women
(67% versus 26%; p = 0.008) and had a lower frequency of mitral
regurgitation (7% versus 38%; p = 0.02). The 15 patients dying suddenly
with isolated MVP also were less likely to have evidence of ruptured
chordae tendineae (29% versus 67%; p = 0.04).
StatusNot started

Funding

  • National Institutes of Health: $868,545.00
  • National Institutes of Health: $1,862,058.00
  • National Institutes of Health
  • National Institutes of Health: $1,017,582.00
  • National Institutes of Health: $1,335,113.00
  • National Institutes of Health: $750,234.00

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