SPECIALIZED CENTER OF RESEARCH IN OSTEOPOROSIS

Project: Research project

Description

This is a Program Project application for a Specialized Center of
Research in Osteoporosis to be established at Creighton
University manned by 4 experienced investigators. The theme of
the Center is research into the etiology, prevention and treatment
of osteoporosis. The 7 projects in this proposal will join 9 other
current or pending projects. The projects are; 1) Family Studies
in Osteoporosis, which will characterize the inheritance of
osteoporosis, something which has not previously been
accomplished. 2) Bone Histomorphometry Before and After
Menopause which, will characterize the changes in bone cell
function that underlie the rapid loss of bone occurring in humans
immediately after menopause. 3) Nutrition and Bone Loss after
Ovariectomy which will be a study of the ovariectomized rat as a
model of trabecular bone loss, and the influence of dietary
manipulations on that loss. 4) Identification and Treatment of
Calcium Deficiency which will attempt to find a method of
identifying dietary calcium deficiency in otherwise healthy
women, and test whether giving calcium to these persons will
inhibit bone loss. 5) Calcium Bioavailability from Certain Plant
Sources, which will determine the extent to which oxalate and
phytate interfere with calcium absorption, and assess calcium
absorbability from several plant foods. 6) Restoration of Bone
Mass by "Coherence" Treatment, which will be a trial of a method
of restoring lost bone by activating remodeling sites, suppressing
their resorptive activity, and then allowing bone formation to
overfill the shallow resorption cavities, creating new trabecular
bone. 7) Effect of a Strength Training Program on Bone Density,
which will be a test of whether strength training of the muscles of
the spine and hip will increase bone mass at these sites. These
projects will advance the understanding of osteoporosis, and will
bring us closer to reducing the morbidity and mortality associated
with this condition which afflicts nearly half of our elderly
population.
StatusFinished
Effective start/end date9/30/8712/31/97

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $923,632.00
  • National Institutes of Health
  • National Institutes of Health: $50,000.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,084,566.00
  • National Institutes of Health: $996,043.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Osteoporosis
Bone and Bones
Calcium
Research
Menopause
Resistance Training
Biological Availability
Progestins
Oxalates
Dietary Calcium
Bone Remodeling
Edible Plants
Therapeutics
Estrogens
National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.)
Morbidity
Bone Density
Osteogenesis
Food
Mortality