THE ROLE OF EGFR IN UV-INDUCED SKIN CARCINOGENESIS

Project: Research project

Project Details

Description

DESCRIPTION (Taken from the Candidate's Abstract)
Ultraviolet radiation (UV) exposure is believed to be the major environmental
risk factor contributing to the development of non-melanoma skin cancer, the
most common cancer in Caucasians in the United States. UV has been shown to
activate the epidermal growth factor receptor (EGFR) in epithelial cells.
Exposure to UV also induces cell proliferation, epidermal hyperplasia,
apoptosis, and skin tumors in genetically-initiated v-Ha-ras transgenic TG.AC
mice. Activation of EGFR is mitogenic to keratinocytes and contributes to
skin tumor growth in v-Ha-ras initiated cells. This proposal is designed to
test the hypothesis that UV-induced activation of EGFR contributes to UV-
induced skin tumor development, suggesting that blockade of EGFR signaling has
potential for prevention of UV-induced skin tumors. Specific aim 1 will
determine whether UV activates EGFR in mouse and human skin and keratinocytes
and whether it is active in UV-induced mouse skin papillomas from v-Ha-ras
transgenic TG.AC mice. Specific aim 2 will determine whether EGFR activation
by UV results in increased cell proliferation and suppression of apoptosis in
both human and mouse keratinocytes and skin. Specific aim 3 will determine
whether LTV-induced EGFR activation contributes to v-Ha-ras initiated skin
tumorigenesis.
StatusFinished
Effective start/end date1/23/0112/31/04

Funding

  • National Institute of Environmental Health Sciences: $103,951.00
  • National Institute of Environmental Health Sciences: $107,840.00
  • National Institute of Environmental Health Sciences: $107,840.00

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