Project: Research project

Project Details


Mutations in the TIGR gene are estimated to contribute to 3 percent of
the total cases of open angle glaucoma, but the normal function of TIGR
and the pathogenesis of TIGR-related glaucoma remain unknown. The long
term objective of this project is to elucidate the roles of the TIGR
gene product in eye development, with the hope that this information
will provide a context within which to understand how TIGR mutations
contribute to disease. The immediate goal of the work in this proposal
is to develop animal systems for studying TIGR function during
development. This project has three specific aims. Specific aim 1 is
to obtain TIGR genomic clones from mouse and chicken tissue and to
determine the patterns of TIGR expression in embryonic, neonatal, and
adult eyes. Specific aim 2 is to generate two lines of transgenic mice
with different disruptions in the TIGR gene and to analyze the
consequences of these disruptions on eye development. Specific aim 3
tests the hypothesis that the transcription factor 1mx-b regulates TIGR
expression during embryogenesis. This work will be an important first
step in understanding the roles of TIGR during eye development and
disease, and will be the foundation of future studies.
Effective start/end date9/29/989/28/01


  • National Eye Institute
  • National Eye Institute
  • National Eye Institute: $37,516.00


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