α-L-fucosidase variant and lipid-associated sialic acid in hereditary ovarian cancer

Ibert C. Wells, Henry T. Lynch, Jane F. Lynch

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In a previous study of α-L-fucosidase (ALF) activities in plasma samples from three ovarian cancer-prone kindreds, we observed a significant inverse correlation of cancer susceptibility and enzyme activity. Because a low level of plasma ALF activity is an inherited characteristic that has been termed the "fucosidase variant," the above demonstration has provoked great interest in the fucosidase variant relative to the genetic transmission of ovarian cancer susceptibility. We have now observed in these same plasma samples that the concentrations of lipid-associated sialic acid (LAS) are also inversely correlated with the ALF activities and, therefore, directly correlated with ovarian cancer susceptibility. In the fucosidase variant individual, the ALF is modified intracellularly, but the modified enzyme only exhibits decreased activity in the plasma. For this reason, ALF cannot be involved in tumorigenesis. Rather, the factor that modifies ALF is probably involved and is the inherited character. Therefore, we hypothesize that this modifier is responsible not only for the "fucosidase variant" but also for the elevated concentration of LAS and plays a role in hereditary ovarian cancer.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume25
Issue number2
DOIs
StatePublished - 1987

Fingerprint

alpha-L-Fucosidase
Ovarian Neoplasms
Enzymes
Carcinogenesis
lipid-associated sialic acid
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

α-L-fucosidase variant and lipid-associated sialic acid in hereditary ovarian cancer. / Wells, Ibert C.; Lynch, Henry T.; Lynch, Jane F.

In: Cancer Genetics and Cytogenetics, Vol. 25, No. 2, 1987, p. 247-251.

Research output: Contribution to journalArticle

@article{a48f1c9e0e1848f990af91fe0351db00,
title = "α-L-fucosidase variant and lipid-associated sialic acid in hereditary ovarian cancer",
abstract = "In a previous study of α-L-fucosidase (ALF) activities in plasma samples from three ovarian cancer-prone kindreds, we observed a significant inverse correlation of cancer susceptibility and enzyme activity. Because a low level of plasma ALF activity is an inherited characteristic that has been termed the {"}fucosidase variant,{"} the above demonstration has provoked great interest in the fucosidase variant relative to the genetic transmission of ovarian cancer susceptibility. We have now observed in these same plasma samples that the concentrations of lipid-associated sialic acid (LAS) are also inversely correlated with the ALF activities and, therefore, directly correlated with ovarian cancer susceptibility. In the fucosidase variant individual, the ALF is modified intracellularly, but the modified enzyme only exhibits decreased activity in the plasma. For this reason, ALF cannot be involved in tumorigenesis. Rather, the factor that modifies ALF is probably involved and is the inherited character. Therefore, we hypothesize that this modifier is responsible not only for the {"}fucosidase variant{"} but also for the elevated concentration of LAS and plays a role in hereditary ovarian cancer.",
author = "Wells, {Ibert C.} and Lynch, {Henry T.} and Lynch, {Jane F.}",
year = "1987",
doi = "10.1016/0165-4608(87)90184-1",
language = "English",
volume = "25",
pages = "247--251",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - α-L-fucosidase variant and lipid-associated sialic acid in hereditary ovarian cancer

AU - Wells, Ibert C.

AU - Lynch, Henry T.

AU - Lynch, Jane F.

PY - 1987

Y1 - 1987

N2 - In a previous study of α-L-fucosidase (ALF) activities in plasma samples from three ovarian cancer-prone kindreds, we observed a significant inverse correlation of cancer susceptibility and enzyme activity. Because a low level of plasma ALF activity is an inherited characteristic that has been termed the "fucosidase variant," the above demonstration has provoked great interest in the fucosidase variant relative to the genetic transmission of ovarian cancer susceptibility. We have now observed in these same plasma samples that the concentrations of lipid-associated sialic acid (LAS) are also inversely correlated with the ALF activities and, therefore, directly correlated with ovarian cancer susceptibility. In the fucosidase variant individual, the ALF is modified intracellularly, but the modified enzyme only exhibits decreased activity in the plasma. For this reason, ALF cannot be involved in tumorigenesis. Rather, the factor that modifies ALF is probably involved and is the inherited character. Therefore, we hypothesize that this modifier is responsible not only for the "fucosidase variant" but also for the elevated concentration of LAS and plays a role in hereditary ovarian cancer.

AB - In a previous study of α-L-fucosidase (ALF) activities in plasma samples from three ovarian cancer-prone kindreds, we observed a significant inverse correlation of cancer susceptibility and enzyme activity. Because a low level of plasma ALF activity is an inherited characteristic that has been termed the "fucosidase variant," the above demonstration has provoked great interest in the fucosidase variant relative to the genetic transmission of ovarian cancer susceptibility. We have now observed in these same plasma samples that the concentrations of lipid-associated sialic acid (LAS) are also inversely correlated with the ALF activities and, therefore, directly correlated with ovarian cancer susceptibility. In the fucosidase variant individual, the ALF is modified intracellularly, but the modified enzyme only exhibits decreased activity in the plasma. For this reason, ALF cannot be involved in tumorigenesis. Rather, the factor that modifies ALF is probably involved and is the inherited character. Therefore, we hypothesize that this modifier is responsible not only for the "fucosidase variant" but also for the elevated concentration of LAS and plays a role in hereditary ovarian cancer.

UR - http://www.scopus.com/inward/record.url?scp=0023157249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023157249&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(87)90184-1

DO - 10.1016/0165-4608(87)90184-1

M3 - Article

C2 - 3470114

AN - SCOPUS:0023157249

VL - 25

SP - 247

EP - 251

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -