1,25-dihydroxyvitamin D in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

Ryan Trowbridge, Robert T. Kizer, Sumeet K. Mittal, Devendra K. Agrawal

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The incidence of reflux-related esophageal disease - Barrett's esophagus and esophageal adenocarcinoma - is rising, and the prognosis remains poor. Evidence exists that 1,25-dihydroxyvitamin D may augment the course of colon, breast and prostate cancer but little knowledge exists regarding its impact on disease of the esophagus. Important immune cells involved in reflux-related esophageal disease include CD4+ T cells, macrophages and dendritic cells, and key signaling pathways include Wnt, Hedgehog, NFκ-B and IL-6-JAK-STAT. There is an inter-relationship between these entities and 1,25-dihydroxyvitamin D, which has been described in animal models and some human tissue. Despite this, there is an incomplete understanding of how the immune cell population and signaling pathways contribute to the course and prognosis of Barrett's esophagus and esophageal adenocarcinoma. More investigation with a focus on the clinical outcomes of patients with Barrett's esophagus and esophageal adenocarcinoma and the immune cell population and cell signaling activity in the diseased esophagus is necessary to determine the immunomodulatory role of 1,25-dihydroxyvitamin D in the pathogenesis of esophageal diseases.

Original languageEnglish
Pages (from-to)517-533
Number of pages17
JournalExpert Review of Clinical Immunology
Volume9
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Barrett Esophagus
Esophageal Diseases
Adenocarcinoma
Esophagus
Wnt Signaling Pathway
Colonic Neoplasms
Dendritic Cells
Population
Interleukin-6
Prostatic Neoplasms
Animal Models
Macrophages
Breast Neoplasms
T-Lymphocytes
1,25-dihydroxyvitamin D
Incidence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

1,25-dihydroxyvitamin D in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. / Trowbridge, Ryan; Kizer, Robert T.; Mittal, Sumeet K.; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 9, No. 6, 06.2013, p. 517-533.

Research output: Contribution to journalReview article

@article{9365af05aebd47ee800e76aeccd4d37b,
title = "1,25-dihydroxyvitamin D in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma",
abstract = "The incidence of reflux-related esophageal disease - Barrett's esophagus and esophageal adenocarcinoma - is rising, and the prognosis remains poor. Evidence exists that 1,25-dihydroxyvitamin D may augment the course of colon, breast and prostate cancer but little knowledge exists regarding its impact on disease of the esophagus. Important immune cells involved in reflux-related esophageal disease include CD4+ T cells, macrophages and dendritic cells, and key signaling pathways include Wnt, Hedgehog, NFκ-B and IL-6-JAK-STAT. There is an inter-relationship between these entities and 1,25-dihydroxyvitamin D, which has been described in animal models and some human tissue. Despite this, there is an incomplete understanding of how the immune cell population and signaling pathways contribute to the course and prognosis of Barrett's esophagus and esophageal adenocarcinoma. More investigation with a focus on the clinical outcomes of patients with Barrett's esophagus and esophageal adenocarcinoma and the immune cell population and cell signaling activity in the diseased esophagus is necessary to determine the immunomodulatory role of 1,25-dihydroxyvitamin D in the pathogenesis of esophageal diseases.",
author = "Ryan Trowbridge and Kizer, {Robert T.} and Mittal, {Sumeet K.} and Agrawal, {Devendra K.}",
year = "2013",
month = "6",
doi = "10.1586/eci.13.38",
language = "English",
volume = "9",
pages = "517--533",
journal = "Expert Review of Clinical Immunology",
issn = "1744-666X",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - 1,25-dihydroxyvitamin D in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

AU - Trowbridge, Ryan

AU - Kizer, Robert T.

AU - Mittal, Sumeet K.

AU - Agrawal, Devendra K.

PY - 2013/6

Y1 - 2013/6

N2 - The incidence of reflux-related esophageal disease - Barrett's esophagus and esophageal adenocarcinoma - is rising, and the prognosis remains poor. Evidence exists that 1,25-dihydroxyvitamin D may augment the course of colon, breast and prostate cancer but little knowledge exists regarding its impact on disease of the esophagus. Important immune cells involved in reflux-related esophageal disease include CD4+ T cells, macrophages and dendritic cells, and key signaling pathways include Wnt, Hedgehog, NFκ-B and IL-6-JAK-STAT. There is an inter-relationship between these entities and 1,25-dihydroxyvitamin D, which has been described in animal models and some human tissue. Despite this, there is an incomplete understanding of how the immune cell population and signaling pathways contribute to the course and prognosis of Barrett's esophagus and esophageal adenocarcinoma. More investigation with a focus on the clinical outcomes of patients with Barrett's esophagus and esophageal adenocarcinoma and the immune cell population and cell signaling activity in the diseased esophagus is necessary to determine the immunomodulatory role of 1,25-dihydroxyvitamin D in the pathogenesis of esophageal diseases.

AB - The incidence of reflux-related esophageal disease - Barrett's esophagus and esophageal adenocarcinoma - is rising, and the prognosis remains poor. Evidence exists that 1,25-dihydroxyvitamin D may augment the course of colon, breast and prostate cancer but little knowledge exists regarding its impact on disease of the esophagus. Important immune cells involved in reflux-related esophageal disease include CD4+ T cells, macrophages and dendritic cells, and key signaling pathways include Wnt, Hedgehog, NFκ-B and IL-6-JAK-STAT. There is an inter-relationship between these entities and 1,25-dihydroxyvitamin D, which has been described in animal models and some human tissue. Despite this, there is an incomplete understanding of how the immune cell population and signaling pathways contribute to the course and prognosis of Barrett's esophagus and esophageal adenocarcinoma. More investigation with a focus on the clinical outcomes of patients with Barrett's esophagus and esophageal adenocarcinoma and the immune cell population and cell signaling activity in the diseased esophagus is necessary to determine the immunomodulatory role of 1,25-dihydroxyvitamin D in the pathogenesis of esophageal diseases.

UR - http://www.scopus.com/inward/record.url?scp=84878702519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878702519&partnerID=8YFLogxK

U2 - 10.1586/eci.13.38

DO - 10.1586/eci.13.38

M3 - Review article

VL - 9

SP - 517

EP - 533

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

SN - 1744-666X

IS - 6

ER -