1,25-Dihydroxyvitamin D3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

John Christopher G. Gallagher, C. M. Jerpbak, W. S S Jee, K. A. Johnson, H. F. DeLuca, B. L. Riggs

Research output: Contribution to journalArticle

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Abstract

We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

Original languageEnglish
Pages (from-to)3325-3329
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number10 I
DOIs
StatePublished - 1982
Externally publishedYes

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Postmenopausal Osteoporosis
Calcitriol
Calcium
Bone and Bones
Bone Resorption
Osteogenesis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics
  • General

Cite this

1,25-Dihydroxyvitamin D3 : Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. / Gallagher, John Christopher G.; Jerpbak, C. M.; Jee, W. S S; Johnson, K. A.; DeLuca, H. F.; Riggs, B. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 10 I, 1982, p. 3325-3329.

Research output: Contribution to journalArticle

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