1,25-Dihydroxyvitamin D3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

J. C. Gallagher, C. M. Jerpbak, W. S.S. Jee, K. A. Johnson, H. F. DeLuca, B. L. Riggs

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We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

Original languageEnglish (US)
Pages (from-to)3325-3329
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number10 I
StatePublished - Dec 1 1982
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • General

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