1,25-Dihydroxyvitamin D3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

J. C. Gallagher; C. M. Jerpbak; W. S.S. Jee; K. A. Johnson; H. F. DeLuca; B. L. Riggs

doi:10.1073/pnas.79.10.3325

1,25-Dihydroxyvitamin D₃: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

J. C. Gallagher, C. M. Jerpbak, W. S.S. Jee, K. A. Johnson, H. F. DeLuca, B. L. Riggs

Research output: Contribution to journal › Article

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Abstract

We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D₃ in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

Original language	English (US)
Pages (from-to)	3325-3329
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	10 I
DOIs	https://doi.org/10.1073/pnas.79.10.3325
State	Published - Dec 1 1982
Externally published	Yes

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Gallagher, J. C., Jerpbak, C. M., Jee, W. S. S., Johnson, K. A., DeLuca, H. F., & Riggs, B. L. (1982). 1,25-Dihydroxyvitamin D₃: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proceedings of the National Academy of Sciences of the United States of America, 79(10 I), 3325-3329. https://doi.org/10.1073/pnas.79.10.3325

1,25-Dihydroxyvitamin D₃ : Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. / Gallagher, J. C.; Jerpbak, C. M.; Jee, W. S.S.; Johnson, K. A.; DeLuca, H. F.; Riggs, B. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 10 I, 01.12.1982, p. 3325-3329.

Research output: Contribution to journal › Article

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10.1073/pnas.79.10.3325