1,25-Dihydroxyvitamin D3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

J. C. Gallagher; C. M. Jerpbak; W. S.S. Jee; K. A. Johnson; H. F. DeLuca; B. L. Riggs

doi:10.1073/pnas.79.10.3325

1,25-Dihydroxyvitamin D₃: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

J. C. Gallagher, C. M. Jerpbak, W. S.S. Jee, K. A. Johnson, H. F. DeLuca, B. L. Riggs

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D₃ in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

Original language	English (US)
Pages (from-to)	3325-3329
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	10 I
DOIs	https://doi.org/10.1073/pnas.79.10.3325
State	Published - 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1073/pnas.79.10.3325

Cite this

Gallagher, J. C., Jerpbak, C. M., Jee, W. S. S., Johnson, K. A., DeLuca, H. F., & Riggs, B. L. (1982). 1,25-Dihydroxyvitamin D₃: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proceedings of the National Academy of Sciences of the United States of America, 79(10 I), 3325-3329. https://doi.org/10.1073/pnas.79.10.3325

1,25-Dihydroxyvitamin D₃ : Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. / Gallagher, J. C.; Jerpbak, C. M.; Jee, W. S.S.; Johnson, K. A.; DeLuca, H. F.; Riggs, B. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 10 I, 1982, p. 3325-3329.

Research output: Contribution to journal › Article › peer-review

@article{998b98484584459690aeb5340cb17d77,

title = "1,25-Dihydroxyvitamin D3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis",

abstract = "We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P",

author = "Gallagher, {J. C.} and Jerpbak, {C. M.} and Jee, {W. S.S.} and Johnson, {K. A.} and DeLuca, {H. F.} and Riggs, {B. L.}",

year = "1982",

doi = "10.1073/pnas.79.10.3325",

language = "English (US)",

volume = "79",

pages = "3325--3329",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "10 I",

}

TY - JOUR

T1 - 1,25-Dihydroxyvitamin D3

T2 - Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

AU - Gallagher, J. C.

AU - Jerpbak, C. M.

AU - Jee, W. S.S.

AU - Johnson, K. A.

AU - DeLuca, H. F.

AU - Riggs, B. L.

PY - 1982

Y1 - 1982

N2 - We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

AB - We evaluated the effects of therapy with a small dose (0.5 μg/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7 ± 3%), calcium balance was negative (-59 ± 22 mg/day), and bone resorption rate (297 ± 40 mg/day) exceeded bone formation rate (239 ± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27 ± 3%. P

UR - http://www.scopus.com/inward/record.url?scp=0342447210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342447210&partnerID=8YFLogxK

U2 - 10.1073/pnas.79.10.3325

DO - 10.1073/pnas.79.10.3325

M3 - Article

C2 - 6954482

AN - SCOPUS:0342447210

VL - 79

SP - 3325

EP - 3329

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 10 I

ER -

1,25-Dihydroxyvitamin D₃: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this