13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Ferenc Ötvös; Géza Tóth; Sándor Lovas; Csaba Simon; Sándor Hosztafi

doi:10.1002/hlca.19960790114

13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Ferenc Ötvös, Géza Tóth, Sándor Lovas, Csaba Simon, Sándor Hosztafi

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

Original language	English (US)
Pages (from-to)	133-136
Number of pages	4
Journal	Helvetica Chimica Acta
Volume	79
Issue number	1
DOIs	https://doi.org/10.1002/hlca.19960790114
State	Published - 1996

All Science Journal Classification (ASJC) codes

Catalysis
Biochemistry
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.1002/hlca.19960790114

Cite this

@article{fe573c37f1b9411990469d06d5c4ba28,

title = "13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity",

abstract = "The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).",

author = "Ferenc {\"O}tv{\"o}s and G{\'e}za T{\'o}th and S{\'a}ndor Lovas and Csaba Simon and S{\'a}ndor Hosztafi",

year = "1996",

doi = "10.1002/hlca.19960790114",

language = "English (US)",

volume = "79",

pages = "133--136",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

publisher = "Verlag Helvetica Chimica Acta AG",

number = "1",

}

TY - JOUR

T1 - 13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

AU - Ötvös, Ferenc

AU - Tóth, Géza

AU - Lovas, Sándor

AU - Simon, Csaba

AU - Hosztafi, Sándor

PY - 1996

Y1 - 1996

N2 - The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

AB - The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

UR - http://www.scopus.com/inward/record.url?scp=0041022342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041022342&partnerID=8YFLogxK

U2 - 10.1002/hlca.19960790114

DO - 10.1002/hlca.19960790114

M3 - Article

AN - SCOPUS:0041022342

VL - 79

SP - 133

EP - 136

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

SN - 0018-019X

IS - 1

ER -

13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this