25-hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones

Stacie Nguyen, Leo Baggerly, Christine French, Robert P. Heaney, Edward D. Gorham, Cedric F. Garland

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Abstract

Objectives. Increasing 25-hydroxyvitamin D serum levels can prevent a wide range of diseases. There is a concern about increasing kidney stone risk with vitamin D supplementation. We used Grassroots Health data to examine the relationship between vitamin D status and kidney stone incidence. Methods. The study included 2012 participants followed prospectively for a median of 19 months. Thirteen individuals self-reported kidney stones during the study period. Multivariate logistic regression was applied to assess the association between vitamin D status and kidney stones. Results. We found no statistically significant association between serum 25-hydroxyvitamin D and kidney stones (P = .42). Body mass index was significantly associated with kidney stone risk (odds ratio = 3.5; 95% confidence interval = 1.1, 11.3). Conclusions. We concluded that a serum 25-hydroxyvitamin D level of 20 to 100 nanograms per milliliter has no significant association with kidney stone incidence.

Original languageEnglish
Pages (from-to)1783-1787
Number of pages5
JournalAmerican Journal of Public Health
Volume104
Issue number9
DOIs
StatePublished - 2014

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All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Nguyen, S., Baggerly, L., French, C., Heaney, R. P., Gorham, E. D., & Garland, C. F. (2014). 25-hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones. American Journal of Public Health, 104(9), 1783-1787. https://doi.org/10.2105/AJPH.2013.301368