3H]-imipramine binding sites in fawn-hooded rats

Thomas F. Murray, B. R. DeBarrows, D. J. Prieur, K. M. Meyers

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The existence of high-affinity [3H]-imipramine recognition sites was demonstrated in membranes prepared from the cerebral cortex, hypothalamus and platelets obtained from fawn-hooded rats. The Bmax and Kd values for [3H]-imipramine binding to cerebral cortical membranes were virtually identical to thos obtained with cortical membrane preparations of Sprague-Dawley rats. An NBR strain of rats, genetically related to fawn-hooded rats, was found to have significantly higher levels of [3H]-imipramine binding sites in cerebral cortical membranes when compared to fawn-hooded and Sprague-Dawley rats. All four strains of rats examined possessed extremely high densities of [3H]-imipramine binding sites in a purified platelet membrane fraction. These results do not support the finding of others that the cerebral cortex and platelets of fawn-hooded rats are virtually devoid of [3H]-imipramine binding sites.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalNeuropharmacology
Volume22
Issue number6
DOIs
StatePublished - 1983
Externally publishedYes

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Imipramine
Binding Sites
Membranes
Blood Platelets
Cerebral Cortex
Sprague Dawley Rats
Hypothalamus

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

3H]-imipramine binding sites in fawn-hooded rats. / Murray, Thomas F.; DeBarrows, B. R.; Prieur, D. J.; Meyers, K. M.

In: Neuropharmacology, Vol. 22, No. 6, 1983, p. 781-784.

Research output: Contribution to journalArticle

Murray, TF, DeBarrows, BR, Prieur, DJ & Meyers, KM 1983, ' 3H]-imipramine binding sites in fawn-hooded rats', Neuropharmacology, vol. 22, no. 6, pp. 781-784. https://doi.org/10.1016/0028-3908(83)90103-X
Murray, Thomas F. ; DeBarrows, B. R. ; Prieur, D. J. ; Meyers, K. M. / 3H]-imipramine binding sites in fawn-hooded rats. In: Neuropharmacology. 1983 ; Vol. 22, No. 6. pp. 781-784.
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