A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis

Zi Hui Tang, Peng Xiao, Shu Feng Lei, Fei Yan Deng, Lan Juan Zhao, Hong Yi Deng, Li Jun Tan, Hui Shen, Dong Hai Xiong, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

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Abstract

Context: A genome-wide bivariate analysis was conducted for body fat mass (BFM) and bone mineral density (BMD) in a large Caucasian sample. We found some quantitative trait loci shared by BFM and BMD in the total sample and the gender-specific subgroups, and quantitative trait loci with potential pleiotropy were disclosed. BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown. Objective: To identify systemically the shared genomic regions for BFM and BMD, we performed a bivariate whole-genome linkage scan in 4498 Caucasian individuals from 451 families for BFM and BMD at the hip, spine, and wrist, respectively. Linkage analyses were performed in the total sample and the male and female subgroups, respectively. Results: In the entire sample, suggestive linkages were detected at 7p22-p21 (LOD 2.69) for BFM and spine BMD, 6q27 (LOD 2.30) for BFM and hip BMD, and 11q13 (LOD 2.64) for BFM and wrist BMD. Male-specific suggestive linkages were found at 13q12 (LOD 3.23) for BFM and spine BMD and at 7q21 (LOD 2.59) for BFM and hip BMD. Female-specific suggestive LOD scores were 3.32 at 15q13 for BFM and spine BMD and 3.15 at 6p25-24 for BFM and wrist BMD. Conclusions: Several shared genomic regions for BFM and BMD were identified here. Our data may benefit further positional and functional studies, aimed at eventually uncovering the complex mechanism underlying the shared genetic determination of obesity and osteoporosis.

Original languageEnglish
Pages (from-to)2751-2757
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number7
DOIs
StatePublished - Jul 2007

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Bone Density
Osteoporosis
Minerals
Adipose Tissue
Bone
Obesity
Genes
Fats
Genome
Spine
Wrist
Pelvic Bones
Quantitative Trait Loci
Hip

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. / Tang, Zi Hui; Xiao, Peng; Lei, Shu Feng; Deng, Fei Yan; Zhao, Lan Juan; Deng, Hong Yi; Tan, Li Jun; Shen, Hui; Xiong, Dong Hai; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 7, 07.2007, p. 2751-2757.

Research output: Contribution to journalArticle

Tang, ZH, Xiao, P, Lei, SF, Deng, FY, Zhao, LJ, Deng, HY, Tan, LJ, Shen, H, Xiong, DH, Recker, RR & Deng, HW 2007, 'A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 7, pp. 2751-2757. https://doi.org/10.1210/jc.2006-2607
Tang, Zi Hui ; Xiao, Peng ; Lei, Shu Feng ; Deng, Fei Yan ; Zhao, Lan Juan ; Deng, Hong Yi ; Tan, Li Jun ; Shen, Hui ; Xiong, Dong Hai ; Recker, Robert R. ; Deng, Hong Wen. / A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 7. pp. 2751-2757.
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AU - Xiao, Peng

AU - Lei, Shu Feng

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AU - Zhao, Lan Juan

AU - Deng, Hong Yi

AU - Tan, Li Jun

AU - Shen, Hui

AU - Xiong, Dong Hai

AU - Recker, Robert R.

AU - Deng, Hong Wen

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N2 - Context: A genome-wide bivariate analysis was conducted for body fat mass (BFM) and bone mineral density (BMD) in a large Caucasian sample. We found some quantitative trait loci shared by BFM and BMD in the total sample and the gender-specific subgroups, and quantitative trait loci with potential pleiotropy were disclosed. BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown. Objective: To identify systemically the shared genomic regions for BFM and BMD, we performed a bivariate whole-genome linkage scan in 4498 Caucasian individuals from 451 families for BFM and BMD at the hip, spine, and wrist, respectively. Linkage analyses were performed in the total sample and the male and female subgroups, respectively. Results: In the entire sample, suggestive linkages were detected at 7p22-p21 (LOD 2.69) for BFM and spine BMD, 6q27 (LOD 2.30) for BFM and hip BMD, and 11q13 (LOD 2.64) for BFM and wrist BMD. Male-specific suggestive linkages were found at 13q12 (LOD 3.23) for BFM and spine BMD and at 7q21 (LOD 2.59) for BFM and hip BMD. Female-specific suggestive LOD scores were 3.32 at 15q13 for BFM and spine BMD and 3.15 at 6p25-24 for BFM and wrist BMD. Conclusions: Several shared genomic regions for BFM and BMD were identified here. Our data may benefit further positional and functional studies, aimed at eventually uncovering the complex mechanism underlying the shared genetic determination of obesity and osteoporosis.

AB - Context: A genome-wide bivariate analysis was conducted for body fat mass (BFM) and bone mineral density (BMD) in a large Caucasian sample. We found some quantitative trait loci shared by BFM and BMD in the total sample and the gender-specific subgroups, and quantitative trait loci with potential pleiotropy were disclosed. BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown. Objective: To identify systemically the shared genomic regions for BFM and BMD, we performed a bivariate whole-genome linkage scan in 4498 Caucasian individuals from 451 families for BFM and BMD at the hip, spine, and wrist, respectively. Linkage analyses were performed in the total sample and the male and female subgroups, respectively. Results: In the entire sample, suggestive linkages were detected at 7p22-p21 (LOD 2.69) for BFM and spine BMD, 6q27 (LOD 2.30) for BFM and hip BMD, and 11q13 (LOD 2.64) for BFM and wrist BMD. Male-specific suggestive linkages were found at 13q12 (LOD 3.23) for BFM and spine BMD and at 7q21 (LOD 2.59) for BFM and hip BMD. Female-specific suggestive LOD scores were 3.32 at 15q13 for BFM and spine BMD and 3.15 at 6p25-24 for BFM and wrist BMD. Conclusions: Several shared genomic regions for BFM and BMD were identified here. Our data may benefit further positional and functional studies, aimed at eventually uncovering the complex mechanism underlying the shared genetic determination of obesity and osteoporosis.

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