Abstract
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 736-742 |
| Number of pages | 7 |
| Journal | American journal of human genetics |
| Volume | 52 |
| Issue number | 4 |
| State | Published - Jan 1 1993 |
All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
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Feunteun, J., Narod, S. A., Lynch, H. T., Watson, P., Conway, T., Lynch, J., Parboosingh, J., O'Connell, P., White, R., & Lenoir, G. M. (1993). A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. American journal of human genetics, 52(4), 736-742.