A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

J. Feunteun; S. A. Narod; H. T. Lynch; P. Watson; T. Conway; J. Lynch; J. Parboosingh; P. O'Connell; R. White; G. M. Lenoir

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

J. Feunteun, S. A. Narod, H. T. Lynch, P. Watson, T. Conway, J. Lynch, J. Parboosingh, P. O'Connell, R. White, G. M. Lenoir

Department of Preventive Medicine

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

Original language	English (US)
Pages (from-to)	736-742
Number of pages	7
Journal	American journal of human genetics
Volume	52
Issue number	4
State	Published - 1993

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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title = "A breast-ovarian cancer susceptibility gene maps to chromosome 17q21",

abstract = "Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.",

author = "J. Feunteun and Narod, {S. A.} and Lynch, {H. T.} and P. Watson and T. Conway and J. Lynch and J. Parboosingh and P. O'Connell and R. White and Lenoir, {G. M.}",

year = "1993",

language = "English (US)",

volume = "52",

pages = "736--742",

journal = "American Journal of Human Genetics",

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TY - JOUR

T1 - A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

AU - Feunteun, J.

AU - Narod, S. A.

AU - Lynch, H. T.

AU - Watson, P.

AU - Conway, T.

AU - Lynch, J.

AU - Parboosingh, J.

AU - O'Connell, P.

AU - White, R.

AU - Lenoir, G. M.

PY - 1993

Y1 - 1993

N2 - Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

AB - Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

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