A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

Jean Feunteun, Steven A. Narod, Henry T. Lynch, Patrice Watson, Theresa Conway, Jane Lynch, Jillian Parboosingh, Peter O'Connell, Ray White, Gilbert M. Lenoir

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34 Scopus citations

Abstract

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

Original languageEnglish
Pages (from-to)736-742
Number of pages7
JournalAmerican Journal of Human Genetics
Volume52
Issue number4
Publication statusPublished - Apr 1993

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All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Feunteun, J., Narod, S. A., Lynch, H. T., Watson, P., Conway, T., Lynch, J., ... Lenoir, G. M. (1993). A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. American Journal of Human Genetics, 52(4), 736-742.