Abstract
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
| Original language | English |
|---|---|
| Pages (from-to) | 736-742 |
| Number of pages | 7 |
| Journal | American Journal of Human Genetics |
| Volume | 52 |
| Issue number | 4 |
| State | Published - Apr 1993 |
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All Science Journal Classification (ASJC) codes
- Genetics
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A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. / Feunteun, Jean; Narod, Steven A.; Lynch, Henry T.; Watson, Patrice; Conway, Theresa; Lynch, Jane; Parboosingh, Jillian; O'Connell, Peter; White, Ray; Lenoir, Gilbert M.
In: American Journal of Human Genetics, Vol. 52, No. 4, 04.1993, p. 736-742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A breast-ovarian cancer susceptibility gene maps to chromosome 17q21
AU - Feunteun, Jean
AU - Narod, Steven A.
AU - Lynch, Henry T.
AU - Watson, Patrice
AU - Conway, Theresa
AU - Lynch, Jane
AU - Parboosingh, Jillian
AU - O'Connell, Peter
AU - White, Ray
AU - Lenoir, Gilbert M.
PY - 1993/4
Y1 - 1993/4
N2 - Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
AB - Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
UR - http://www.scopus.com/inward/record.url?scp=0027494346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027494346&partnerID=8YFLogxK
M3 - Article
C2 - 8460639
AN - SCOPUS:0027494346
VL - 52
SP - 736
EP - 742
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 4
ER -