A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects

Donald B. Kimmel, Robert R. Recker, John Christopher G. Gallagher, Ashok S. Vaswani, John F. Aloia

Research output: Contribution to journalArticle

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Abstract

Transilial bone biopsies following in vivo fluorochrome labeling were obtained from 90 women with postmenopausal osteoporosis and 34 healthy post-menopausal women. Standard histomorphometric data were collected from undecalcified sections. The distribution of values for both structural and remodelling indices was the same for each group. Bone volume was 35% lower (P <0.001), wall thickness was 12% lower (P <0.001), and trabecular thickness was 11% lower (P <0.02) in osteoporotics. Trabecular separation was 34% greater (P <0.001) and trabecular number was 36% lower (P <0.001) in osteoporotics. Biopsy core width was 11% less (P <0.02) and cortical width was 35-50% less (P <0.001) in osteoporotics. Static indices of remodelling, mineralizing surfaces, and mineral apposition rate were similar in the two groups. The absolute values for bone histomorphometric variables for both groups are similar to most published data. Osteoporotics had poorer bone structure, marked by decreased trabecular connectivity and thin cortices. There were no major differences in dynamic indices of remodelling. Since the histomorphometric data were distributed the same in both groups, special subsets of osteoporotic subjects not in the normal population did not exist.

Original languageEnglish
Pages (from-to)217-235
Number of pages19
JournalBone and Mineral
Volume11
Issue number2
DOIs
StatePublished - 1990

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Bone
Bone and Bones
Biopsy
Postmenopausal Osteoporosis
Fluorescent Dyes
Labeling
Minerals
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Surgery

Cite this

A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects. / Kimmel, Donald B.; Recker, Robert R.; Gallagher, John Christopher G.; Vaswani, Ashok S.; Aloia, John F.

In: Bone and Mineral, Vol. 11, No. 2, 1990, p. 217-235.

Research output: Contribution to journalArticle

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