TY - JOUR
T1 - A comparison of parathyroid-gland function in haemodialysis patients with different forms of renal osteodystrophy
AU - Felsenfeld, A. J.
AU - Rodriguez, M.
AU - Dunlay, R.
AU - Llach, F.
N1 - Funding Information:
Acknowledgements. Parts of this study were presented previously at the Annual Meeting of the American Society of Nephrology in 1988 and 1989. This study was in part supported by Merit Review funds from the Veterans Administration. The authors also wish to thank Ms Jan Myers for technical assistance.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTH(Max)) and inhibited (PTH(Min)) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTH(Max) was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTH(Base): PTH(Max)), the ionised calcium concentration at which basal (ICA(Base)), maximally stimulated (ICA(Max)), and maximally inhibited (ICA(Min)) PTH values were observed, and the slope of the PTH-calcium curve. Both PTH(Max) and PTH(Min) were greater in OF than the other two groups (P50 and the ICA(Max) were greater (P50 and ICA(Max) indicates a shift of the PTH-calcium curve to the right; and (c) the steeper slope of the PTH-calcium curve (OF versus LTAABD) indicates that the sensitivity of parathyroid cells was enhanced.
AB - Parathyroid function was studied in three different histological forms of renal osteodystrophy: osteitis fibrosa (OF), low-turnover aluminium-associated bone disease (LTAABD), and aplastic bone disease without aluminium (ABD). Parathyroid function was determined by the evaluation of the sigmoidal parathyroid hormone-(PTH)-calcium curve, which was obtained by the performance of a reduced calcium and an increased calcium haemodialysis. Parameters of the sigmoidal PTH-calcium curve evaluated included maximally stimulated (PTH(Max)) and inhibited (PTH(Min)) PTH, the set point of calcium for PTH (ICA50), defined as the ionised calcium concentration at which PTH(Max) was reduced by 50%, the ratio of basal PTH to maximally stimulated PTH (PTH(Base): PTH(Max)), the ionised calcium concentration at which basal (ICA(Base)), maximally stimulated (ICA(Max)), and maximally inhibited (ICA(Min)) PTH values were observed, and the slope of the PTH-calcium curve. Both PTH(Max) and PTH(Min) were greater in OF than the other two groups (P50 and the ICA(Max) were greater (P50 and ICA(Max) indicates a shift of the PTH-calcium curve to the right; and (c) the steeper slope of the PTH-calcium curve (OF versus LTAABD) indicates that the sensitivity of parathyroid cells was enhanced.
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U2 - 10.1093/ndt/6.4.244
DO - 10.1093/ndt/6.4.244
M3 - Article
C2 - 1881578
AN - SCOPUS:0025868455
VL - 6
SP - 244
EP - 251
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 4
ER -