A comparison of stent-induced stenosis in coronary and peripheral arteries

K. D. Krueger, A. K. Mitra, M. G. DelCore, W. J. Hunter, D. K. Agrawal

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background and objectives: Restenosis is a complication of interventional procedures such as angioplasty and stenting, often limiting the success of these procedures. Knowledge regarding the relative behaviour of different arteries after these procedures is limited, despite the extensive use of different vascular models. Although the results from studies using different vessels are analysed to predict the behaviour of coronary arteries and other vasculature, direct controlled comparisons between different arteries are necessary for a better understanding of the differential response to restenosis. Methods: This study examines the response to stenting in coronary and internal iliac arteries as characterised by intimal hyperplasia and restenosis. In a swine model of in-stent stenosis, coronary arteries exhibited higher levels of intimal hyperplasia and per cent stenosis than internal iliac arteries. Results: After normalisation for injury score, coronary arteries were found to undergo 47% more intimal hyperplasia (p

Original languageEnglish (US)
Pages (from-to)575-579
Number of pages5
JournalJournal of Clinical Pathology
Volume59
Issue number6
DOIs
StatePublished - Jun 1 2006

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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