A Computer Investigation into the Origin of the Code

Marc S. Rendell

doi:10.1021/ja00767a051

A Computer Investigation into the Origin of the Code

Marc S. Rendell

Department of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

Original language	English (US)
Pages (from-to)	4337-4341
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	94
Issue number	12
DOIs	https://doi.org/10.1021/ja00767a051
State	Published - Jun 1 1972

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja00767a051

Fingerprint Dive into the research topics of 'A Computer Investigation into the Origin of the Code'. Together they form a unique fingerprint.

Cite this

@article{4c58422d1665499e8cd9d7077b84f6a2,

title = "A Computer Investigation into the Origin of the Code",

abstract = "Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.",

author = "Rendell, {Marc S.}",

year = "1972",

month = jun,

day = "1",

doi = "10.1021/ja00767a051",

language = "English (US)",

volume = "94",

pages = "4337--4341",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - A Computer Investigation into the Origin of the Code

AU - Rendell, Marc S.

PY - 1972/6/1

Y1 - 1972/6/1

N2 - Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

AB - Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0015505908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015505908&partnerID=8YFLogxK

U2 - 10.1021/ja00767a051

DO - 10.1021/ja00767a051

M3 - Article

C2 - 5036652

AN - SCOPUS:0015505908

VL - 94

SP - 4337

EP - 4341

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 12

ER -

A Computer Investigation into the Origin of the Code

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this