Abstract
Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 4337-4341 |
| Number of pages | 5 |
| Journal | Journal of the American Chemical Society |
| Volume | 94 |
| Issue number | 12 |
| State | Published - 1972 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
Cite this
A computer investigation into the origin of the code. / Rendell, Marc S.
In: Journal of the American Chemical Society, Vol. 94, No. 12, 1972, p. 4337-4341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A computer investigation into the origin of the code
AU - Rendell, Marc S.
PY - 1972
Y1 - 1972
N2 - Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.
AB - Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015505908&partnerID=8YFLogxK
M3 - Article
C2 - 5036652
AN - SCOPUS:0015505908
VL - 94
SP - 4337
EP - 4341
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 12
ER -