A Computer Investigation into the Origin of the Code

Marc S. Rendell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

Original languageEnglish (US)
Pages (from-to)4337-4341
Number of pages5
JournalJournal of the American Chemical Society
Issue number12
StatePublished - Jun 1 1972

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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