A Computer Investigation into the Origin of the Code

Marc S. Rendell

doi:10.1021/ja00767a051

A Computer Investigation into the Origin of the Code

Marc S. Rendell

Department of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

Original language	English (US)
Pages (from-to)	4337-4341
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	94
Issue number	12
DOIs	https://doi.org/10.1021/ja00767a051
State	Published - Jun 1 1972

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00767a051

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abstract = "Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.",

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AB - Quantum mechanical methods are used to simulate interactions between glycine and polynucleotide base sequences. High-magnitude, configurationally specific interactions with features similar to Watson-Crick base pairing are obtained. Glycine manifests preferential affinities in complexing with the stacked base pairs. The feasibility of selective interaction between polar amino acids and polynucleotide base sequences is considered. The implications of such interactions for the origin of the genetic code are discussed.

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A Computer Investigation into the Origin of the Code

Abstract

All Science Journal Classification (ASJC) codes

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