A corticosteroid receptor in neuronal membranes

Miles Orchinik, Thomas F. Murray, Frank L. Moore

Research output: Contribution to journalArticle

454 Citations (Scopus)

Abstract

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, ouside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.

Original languageEnglish
Pages (from-to)1848-1851
Number of pages4
JournalScience
Volume252
Issue number5014
StatePublished - Jun 28 1991
Externally publishedYes

Fingerprint

Steroid Receptors
Corticosterone
Membranes
Binding Sites
Reproductive Behavior
Synaptic Membranes
Neuropil
Brain
Amphibians
Autoradiography
Adrenal Cortex Hormones
Steroids
Population

All Science Journal Classification (ASJC) codes

  • General

Cite this

Orchinik, M., Murray, T. F., & Moore, F. L. (1991). A corticosteroid receptor in neuronal membranes. Science, 252(5014), 1848-1851.

A corticosteroid receptor in neuronal membranes. / Orchinik, Miles; Murray, Thomas F.; Moore, Frank L.

In: Science, Vol. 252, No. 5014, 28.06.1991, p. 1848-1851.

Research output: Contribution to journalArticle

Orchinik, M, Murray, TF & Moore, FL 1991, 'A corticosteroid receptor in neuronal membranes', Science, vol. 252, no. 5014, pp. 1848-1851.
Orchinik M, Murray TF, Moore FL. A corticosteroid receptor in neuronal membranes. Science. 1991 Jun 28;252(5014):1848-1851.
Orchinik, Miles ; Murray, Thomas F. ; Moore, Frank L. / A corticosteroid receptor in neuronal membranes. In: Science. 1991 ; Vol. 252, No. 5014. pp. 1848-1851.
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