A disorganized innervation of the inner ear persists in the absence of ErbB2

Jacqueline K. Morris, Adel Maklad, Laura A. Hansen, Feng Feng, Christian Sorensen, Kuo Fen Lee, Wendy B. Macklin, Bernd Fritzsch

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

ErbB2 protein is essential for the development of Schwann cells and for the normal fiber growth and myelin formation of peripheral nerves. We have investigated the fate of the otocyst-derived inner ear sensory neurons in the absence of ErbB2 using ErbB2 null mutants. Afferent innervation of the ear sensory epithelia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers in near term embryos. This suggests that mature Schwann cells do not play a role in targeting or maintaining the inner ear innervation. Comparable to the overshooting of nerve fibers, sensory neurons migrate beyond their normal locations into unusual positions in the modiolus. They may miss a stop signal provided by the Schwann cells that are absent as revealed with detailed histology. Reduction of overshooting afferents may be enhanced by a reduction of the neurotrophin Ntf3 transcript to about 25% of wild type. Ntf3 transcript reductions are comparable to an adult model that uses a dominant negative form of ErbB4 expressed in the supporting cells and Schwann cells of the organ of Corti. ErbB2 null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells. Despite the normal presence of Bdnf transcript, afferent fibers are disoriented near the organ of Corti. Efferent fibers do not form an intraganglionic spiral bundle in the absence of spiral ganglia and appear reduced and disorganized. This suggests that either ErbB2 mediated alterations in sensory neurons or the absence of Schwann cells affects efferent fiber growth to the organ of Corti.

Original languageEnglish
Pages (from-to)186-199
Number of pages14
JournalBrain Research
Volume1091
Issue number1
DOIs
StatePublished - May 26 2006

Fingerprint

Schwann Cells
Inner Ear
Organ of Corti
Sensory Receptor Cells
Nerve Growth Factors
Inner Auditory Hair Cells
Spiral Ganglion
Growth
Myelin Sheath
Peripheral Nerves
Nerve Fibers
Ear
Histology
Embryonic Structures
Epithelium
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Morris, J. K., Maklad, A., Hansen, L. A., Feng, F., Sorensen, C., Lee, K. F., ... Fritzsch, B. (2006). A disorganized innervation of the inner ear persists in the absence of ErbB2. Brain Research, 1091(1), 186-199. https://doi.org/10.1016/j.brainres.2006.02.090

A disorganized innervation of the inner ear persists in the absence of ErbB2. / Morris, Jacqueline K.; Maklad, Adel; Hansen, Laura A.; Feng, Feng; Sorensen, Christian; Lee, Kuo Fen; Macklin, Wendy B.; Fritzsch, Bernd.

In: Brain Research, Vol. 1091, No. 1, 26.05.2006, p. 186-199.

Research output: Contribution to journalArticle

Morris, JK, Maklad, A, Hansen, LA, Feng, F, Sorensen, C, Lee, KF, Macklin, WB & Fritzsch, B 2006, 'A disorganized innervation of the inner ear persists in the absence of ErbB2', Brain Research, vol. 1091, no. 1, pp. 186-199. https://doi.org/10.1016/j.brainres.2006.02.090
Morris, Jacqueline K. ; Maklad, Adel ; Hansen, Laura A. ; Feng, Feng ; Sorensen, Christian ; Lee, Kuo Fen ; Macklin, Wendy B. ; Fritzsch, Bernd. / A disorganized innervation of the inner ear persists in the absence of ErbB2. In: Brain Research. 2006 ; Vol. 1091, No. 1. pp. 186-199.
@article{5c8ec9c80dcd4606b64def59583abd92,
title = "A disorganized innervation of the inner ear persists in the absence of ErbB2",
abstract = "ErbB2 protein is essential for the development of Schwann cells and for the normal fiber growth and myelin formation of peripheral nerves. We have investigated the fate of the otocyst-derived inner ear sensory neurons in the absence of ErbB2 using ErbB2 null mutants. Afferent innervation of the ear sensory epithelia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers in near term embryos. This suggests that mature Schwann cells do not play a role in targeting or maintaining the inner ear innervation. Comparable to the overshooting of nerve fibers, sensory neurons migrate beyond their normal locations into unusual positions in the modiolus. They may miss a stop signal provided by the Schwann cells that are absent as revealed with detailed histology. Reduction of overshooting afferents may be enhanced by a reduction of the neurotrophin Ntf3 transcript to about 25{\%} of wild type. Ntf3 transcript reductions are comparable to an adult model that uses a dominant negative form of ErbB4 expressed in the supporting cells and Schwann cells of the organ of Corti. ErbB2 null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells. Despite the normal presence of Bdnf transcript, afferent fibers are disoriented near the organ of Corti. Efferent fibers do not form an intraganglionic spiral bundle in the absence of spiral ganglia and appear reduced and disorganized. This suggests that either ErbB2 mediated alterations in sensory neurons or the absence of Schwann cells affects efferent fiber growth to the organ of Corti.",
author = "Morris, {Jacqueline K.} and Adel Maklad and Hansen, {Laura A.} and Feng Feng and Christian Sorensen and Lee, {Kuo Fen} and Macklin, {Wendy B.} and Bernd Fritzsch",
year = "2006",
month = "5",
day = "26",
doi = "10.1016/j.brainres.2006.02.090",
language = "English",
volume = "1091",
pages = "186--199",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - A disorganized innervation of the inner ear persists in the absence of ErbB2

AU - Morris, Jacqueline K.

AU - Maklad, Adel

AU - Hansen, Laura A.

AU - Feng, Feng

AU - Sorensen, Christian

AU - Lee, Kuo Fen

AU - Macklin, Wendy B.

AU - Fritzsch, Bernd

PY - 2006/5/26

Y1 - 2006/5/26

N2 - ErbB2 protein is essential for the development of Schwann cells and for the normal fiber growth and myelin formation of peripheral nerves. We have investigated the fate of the otocyst-derived inner ear sensory neurons in the absence of ErbB2 using ErbB2 null mutants. Afferent innervation of the ear sensory epithelia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers in near term embryos. This suggests that mature Schwann cells do not play a role in targeting or maintaining the inner ear innervation. Comparable to the overshooting of nerve fibers, sensory neurons migrate beyond their normal locations into unusual positions in the modiolus. They may miss a stop signal provided by the Schwann cells that are absent as revealed with detailed histology. Reduction of overshooting afferents may be enhanced by a reduction of the neurotrophin Ntf3 transcript to about 25% of wild type. Ntf3 transcript reductions are comparable to an adult model that uses a dominant negative form of ErbB4 expressed in the supporting cells and Schwann cells of the organ of Corti. ErbB2 null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells. Despite the normal presence of Bdnf transcript, afferent fibers are disoriented near the organ of Corti. Efferent fibers do not form an intraganglionic spiral bundle in the absence of spiral ganglia and appear reduced and disorganized. This suggests that either ErbB2 mediated alterations in sensory neurons or the absence of Schwann cells affects efferent fiber growth to the organ of Corti.

AB - ErbB2 protein is essential for the development of Schwann cells and for the normal fiber growth and myelin formation of peripheral nerves. We have investigated the fate of the otocyst-derived inner ear sensory neurons in the absence of ErbB2 using ErbB2 null mutants. Afferent innervation of the ear sensory epithelia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers in near term embryos. This suggests that mature Schwann cells do not play a role in targeting or maintaining the inner ear innervation. Comparable to the overshooting of nerve fibers, sensory neurons migrate beyond their normal locations into unusual positions in the modiolus. They may miss a stop signal provided by the Schwann cells that are absent as revealed with detailed histology. Reduction of overshooting afferents may be enhanced by a reduction of the neurotrophin Ntf3 transcript to about 25% of wild type. Ntf3 transcript reductions are comparable to an adult model that uses a dominant negative form of ErbB4 expressed in the supporting cells and Schwann cells of the organ of Corti. ErbB2 null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells. Despite the normal presence of Bdnf transcript, afferent fibers are disoriented near the organ of Corti. Efferent fibers do not form an intraganglionic spiral bundle in the absence of spiral ganglia and appear reduced and disorganized. This suggests that either ErbB2 mediated alterations in sensory neurons or the absence of Schwann cells affects efferent fiber growth to the organ of Corti.

UR - http://www.scopus.com/inward/record.url?scp=33745597871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745597871&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2006.02.090

DO - 10.1016/j.brainres.2006.02.090

M3 - Article

VL - 1091

SP - 186

EP - 199

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -