Abstract
The incidence of pancreatic cancer has been increasing steadily in the United States and other industrialized nations. Its obscure etiology and difficult early diagnosis tend to hobble effective control programs. Innovative methods, such as biomarkers, might provide clues to its inevitable occurrence in high-risk individuals. We studied a family in which four individuals manifested pancreatic cancer verified through two generations. Cell cultures from split-thickness skin biopsy specimens were obtained for 24 members from three generations (17 bloodline relatives, seven family members by marriage) as well as ten nonfamily normal subjects, none with a family history of solid tumors. One of the constant features of human monolayer dermal cultures has been diploidy. Hyperdiploidy, other than tetraploidy, has been rarely observed in cultures from normal subjects without a family history of solid tumors. We observed increased in vitro hyperdiploidy in eight of 17 family members studied.
| Original language | English |
|---|---|
| Pages (from-to) | 2798-2802 |
| Number of pages | 5 |
| Journal | JAMA - Journal of the American Medical Association |
| Volume | 247 |
| Issue number | 20 |
| DOIs | |
| State | Published - May 28 1982 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
A Familial Aggregation of Pancreatic Cancer : An In Vitro Study. / Danes, B. Shannon; Lynch, Henry T.
In: JAMA - Journal of the American Medical Association, Vol. 247, No. 20, 28.05.1982, p. 2798-2802.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Familial Aggregation of Pancreatic Cancer
T2 - An In Vitro Study
AU - Danes, B. Shannon
AU - Lynch, Henry T.
PY - 1982/5/28
Y1 - 1982/5/28
N2 - The incidence of pancreatic cancer has been increasing steadily in the United States and other industrialized nations. Its obscure etiology and difficult early diagnosis tend to hobble effective control programs. Innovative methods, such as biomarkers, might provide clues to its inevitable occurrence in high-risk individuals. We studied a family in which four individuals manifested pancreatic cancer verified through two generations. Cell cultures from split-thickness skin biopsy specimens were obtained for 24 members from three generations (17 bloodline relatives, seven family members by marriage) as well as ten nonfamily normal subjects, none with a family history of solid tumors. One of the constant features of human monolayer dermal cultures has been diploidy. Hyperdiploidy, other than tetraploidy, has been rarely observed in cultures from normal subjects without a family history of solid tumors. We observed increased in vitro hyperdiploidy in eight of 17 family members studied.
AB - The incidence of pancreatic cancer has been increasing steadily in the United States and other industrialized nations. Its obscure etiology and difficult early diagnosis tend to hobble effective control programs. Innovative methods, such as biomarkers, might provide clues to its inevitable occurrence in high-risk individuals. We studied a family in which four individuals manifested pancreatic cancer verified through two generations. Cell cultures from split-thickness skin biopsy specimens were obtained for 24 members from three generations (17 bloodline relatives, seven family members by marriage) as well as ten nonfamily normal subjects, none with a family history of solid tumors. One of the constant features of human monolayer dermal cultures has been diploidy. Hyperdiploidy, other than tetraploidy, has been rarely observed in cultures from normal subjects without a family history of solid tumors. We observed increased in vitro hyperdiploidy in eight of 17 family members studied.
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U2 - 10.1001/jama.1982.03320450032028
DO - 10.1001/jama.1982.03320450032028
M3 - Article
VL - 247
SP - 2798
EP - 2802
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 20
ER -