Abstract
A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].
Original language | English (US) |
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Pages (from-to) | 951-954 |
Number of pages | 4 |
Journal | Journal of the National Cancer Institute |
Volume | 83 |
Issue number | 13 |
DOIs | |
State | Published - Jul 3 1991 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research