A follow-up study of colonic epithelial proliferation as a biomarker in a native-american family with hereditary nonpolyposis colon cancer

P. M. Lynch, M. J. Wargovich, Henry T. Lynch, C. Palmer, Stephen J. Lanspa, T. Drouhard, J. Lynch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].

Original languageEnglish
Pages (from-to)951-954
Number of pages4
JournalJournal of the National Cancer Institute
Volume83
Issue number13
DOIs
StatePublished - Jul 3 1991

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Hereditary Nonpolyposis Colorectal Neoplasms
North American Indians
Biomarkers
Proliferation
Colonic Neoplasms
Labeling
Cancer
Thymidine
Assays
Bromodeoxyuridine
Autoradiography
Immunoenzyme Techniques
Confounding
Reproducibility
Colon
Mucous Membrane
Staining and Labeling
Baseline
Preparation
Population

All Science Journal Classification (ASJC) codes

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

A follow-up study of colonic epithelial proliferation as a biomarker in a native-american family with hereditary nonpolyposis colon cancer. / Lynch, P. M.; Wargovich, M. J.; Lynch, Henry T.; Palmer, C.; Lanspa, Stephen J.; Drouhard, T.; Lynch, J.

In: Journal of the National Cancer Institute, Vol. 83, No. 13, 03.07.1991, p. 951-954.

Research output: Contribution to journalArticle

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