Abstract
A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].
| Original language | English |
|---|---|
| Pages (from-to) | 951-954 |
| Number of pages | 4 |
| Journal | Journal of the National Cancer Institute |
| Volume | 83 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jul 3 1991 |
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All Science Journal Classification (ASJC) codes
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Radiology Nuclear Medicine and imaging
- Oncology
- Cancer Research
Cite this
A follow-up study of colonic epithelial proliferation as a biomarker in a native-american family with hereditary nonpolyposis colon cancer. / Lynch, P. M.; Wargovich, M. J.; Lynch, Henry T.; Palmer, C.; Lanspa, Stephen J.; Drouhard, T.; Lynch, J.
In: Journal of the National Cancer Institute, Vol. 83, No. 13, 03.07.1991, p. 951-954.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A follow-up study of colonic epithelial proliferation as a biomarker in a native-american family with hereditary nonpolyposis colon cancer
AU - Lynch, P. M.
AU - Wargovich, M. J.
AU - Lynch, Henry T.
AU - Palmer, C.
AU - Lanspa, Stephen J.
AU - Drouhard, T.
AU - Lynch, J.
PY - 1991/7/3
Y1 - 1991/7/3
N2 - A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].
AB - A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].
UR - http://www.scopus.com/inward/record.url?scp=0025797593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025797593&partnerID=8YFLogxK
U2 - 10.1093/jnci/83.13.951
DO - 10.1093/jnci/83.13.951
M3 - Article
C2 - 2067038
AN - SCOPUS:0025797593
VL - 83
SP - 951
EP - 954
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 13
ER -