A fuzzy mathematical model determining the risk for carotid intima-medial thickness in recently menopausal women enrolled in the KEEPS study

Alex Shepherd, Virginia M. Miller, Larry W. Hunter, Muthuvel Jayachandran, Davender S. Malik, John N. Mordeson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Carotid intima-medial thickness (CIMT) allows for early detection of carotid atherosclerotic vascular disease. Using fuzzy logic techniques, we propose a model for calculating the risk for predicting CIMT using expert opinion and various factors associated with CIMT in recently menopausal women. Study participants were enrolled in the Kronos Early Estrogen Prevention Study (KEEPS), a four year study where participants were assigned to either oral or transdermal hormone therapy or to the placebo group. The fuzzy mathematical model uses five fuzzy logic methods to calculate this risk factor for CIMT, including the analytic hierarchy process (AHP) method, Guiasu method, Yen method, Dempster-Shafer (DS) method, and the set valued statistical method (SVSM). The four methods, AHP, Guiasu, Yen, DS, and SVSM, were correlated to each other according to the Pearson ranking method. In addition, results showed that the estrogen treatment groups showed a statically significant decrease in calculated CIMT risk compared to placebo when all the methods were combined together (p = 0.0017). Our fuzzy mathematical model provides the first fuzzy mathematical model to predict the risk of CIMT in recently menopausal women and menopausal hormone therapy may be beneficial in reducing this risk.

Original languageEnglish
Pages (from-to)187-201
Number of pages15
JournalNew Mathematics and Natural Computation
Volume10
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Estrogen
Fuzzy Model
Mathematical Model
Mathematical models
Analytic hierarchy process
Hormones
Fuzzy logic
Statistical methods
Analytic Hierarchy Process
Statistical method
Fuzzy Logic
Therapy
Expert Opinion
Estrogens
Risk Factors
Ranking
Calculate
Predict
Decrease

All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Computational Mathematics
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Human-Computer Interaction

Cite this

A fuzzy mathematical model determining the risk for carotid intima-medial thickness in recently menopausal women enrolled in the KEEPS study. / Shepherd, Alex; Miller, Virginia M.; Hunter, Larry W.; Jayachandran, Muthuvel; Malik, Davender S.; Mordeson, John N.

In: New Mathematics and Natural Computation, Vol. 10, No. 3, 2014, p. 187-201.

Research output: Contribution to journalArticle

Shepherd, Alex ; Miller, Virginia M. ; Hunter, Larry W. ; Jayachandran, Muthuvel ; Malik, Davender S. ; Mordeson, John N. / A fuzzy mathematical model determining the risk for carotid intima-medial thickness in recently menopausal women enrolled in the KEEPS study. In: New Mathematics and Natural Computation. 2014 ; Vol. 10, No. 3. pp. 187-201.
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