A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Lan Juan Zhao; Peng Xiao; Yong Jun Liu; Dong Hai Xiong; Hui Shen; Robert R. Recker; Hong Wen Deng

doi:10.1007/s00439-006-0286-y

A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Lan Juan Zhao, Peng Xiao, Yong Jun Liu, Dong Hai Xiong, Hui Shen, Robert R. Recker, Hong Wen Deng

Department of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

Original language	English (US)
Pages (from-to)	145-148
Number of pages	4
Journal	Human Genetics
Volume	121
Issue number	1
DOIs	https://doi.org/10.1007/s00439-006-0286-y
State	Published - Mar 2007

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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title = "A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families",

abstract = "To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.",

author = "Zhao, {Lan Juan} and Peng Xiao and Liu, {Yong Jun} and Xiong, {Dong Hai} and Hui Shen and Recker, {Robert R.} and Deng, {Hong Wen}",

note = "Funding Information: Acknowledgments Investigators of this work were partially supported by grants from NIH (K01 AR021170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The genotyping experiment was performed by Marsh-Weld Center for Medical Genetics and supported by NHLBI Mammalian Genotyping Service (Contract Number HV48141).",

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doi = "10.1007/s00439-006-0286-y",

language = "English (US)",

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AU - Xiao, Peng

AU - Liu, Yong Jun

AU - Xiong, Dong Hai

AU - Shen, Hui

AU - Recker, Robert R.

AU - Deng, Hong Wen

N1 - Funding Information: Acknowledgments Investigators of this work were partially supported by grants from NIH (K01 AR021170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The genotyping experiment was performed by Marsh-Weld Center for Medical Genetics and supported by NHLBI Mammalian Genotyping Service (Contract Number HV48141).

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N2 - To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

AB - To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

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A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Abstract

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