Abstract
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-148 |
| Number of pages | 4 |
| Journal | Human Genetics |
| Volume | 121 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2007 |
All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
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Zhao, L. J., Xiao, P., Liu, Y. J., Xiong, D. H., Shen, H., Recker, R. R., & Deng, H. W. (2007). A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Human Genetics, 121(1), 145-148. https://doi.org/10.1007/s00439-006-0286-y