A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Lan Juan Zhao; Peng Xiao; Yong Jun Liu; Dong Hai Xiong; Hui Shen; Robert R. Recker; Hong Wen Deng

doi:10.1007/s00439-006-0286-y

A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Lan Juan Zhao, Peng Xiao, Yong Jun Liu, Dong Hai Xiong, Hui Shen, Robert R. Recker, Hong Wen Deng

Department of Medicine

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17 Scopus citations

Abstract

To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Human Genetics
Volume	121
Issue number	1
DOIs	https://doi.org/10.1007/s00439-006-0286-y
Publication status	Published - Mar 2007

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All Science Journal Classification (ASJC) codes

Genetics(clinical)
Genetics

Cite this

Zhao, L. J., Xiao, P., Liu, Y. J., Xiong, D. H., Shen, H., Recker, R. R., & Deng, H. W. (2007). A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Human Genetics, 121(1), 145-148. https://doi.org/10.1007/s00439-006-0286-y

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10.1007/s00439-006-0286-y