Abstract
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
| Original language | English |
|---|---|
| Pages (from-to) | 145-148 |
| Number of pages | 4 |
| Journal | Human Genetics |
| Volume | 121 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2007 |
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All Science Journal Classification (ASJC) codes
- Genetics(clinical)
- Genetics
Cite this
A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. / Zhao, Lan Juan; Xiao, Peng; Liu, Yong Jun; Xiong, Dong Hai; Shen, Hui; Recker, Robert R.; Deng, Hong Wen.
In: Human Genetics, Vol. 121, No. 1, 03.2007, p. 145-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families
AU - Zhao, Lan Juan
AU - Xiao, Peng
AU - Liu, Yong Jun
AU - Xiong, Dong Hai
AU - Shen, Hui
AU - Recker, Robert R.
AU - Deng, Hong Wen
PY - 2007/3
Y1 - 2007/3
N2 - To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
AB - To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
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UR - http://www.scopus.com/inward/citedby.url?scp=33947245930&partnerID=8YFLogxK
U2 - 10.1007/s00439-006-0286-y
DO - 10.1007/s00439-006-0286-y
M3 - Article
VL - 121
SP - 145
EP - 148
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 1
ER -