A genotype-first approach to defining the subtypes of a complex disease

Holly Stessman, Raphael Bernier, Evan E. Eichler

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Medical genetics typically entails the detailed characterization of a patient's phenotypes followed by genotyping to discover the responsible gene or mutation. Here, we propose that the systematic discovery of genetic variants associated with complex diseases such as autism are progressing to a point where a reverse strategy may be fruitful in assigning the pathogenic effects of many different genes and in determining whether particular genotypes manifest as clinically recognizable phenotypes. This "genotype-first" approach for complex disease necessitates the development of large, highly integrated networks of researchers, clinicians, and patient families, with the promise of improved therapies for subsets of patients.

Original languageEnglish (US)
Pages (from-to)872-877
Number of pages6
JournalCell
Volume156
Issue number5
DOIs
StatePublished - Feb 27 2014
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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