A giant cystic pheochromocytoma of the adrenal gland

Zenggang Pan; Susan Repertinger; Caishu Deng; Poonam Sharma

doi:10.1007/s12022-008-9016-4

A giant cystic pheochromocytoma of the adrenal gland

Zenggang Pan, Susan Repertinger, Caishu Deng, Poonam Sharma

Department of Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Adrenal pheochromocytomas are rare catecholamine-secreting tumors that originate from chromaffin cells in the adrenal medulla, and giant pheochromocytomas with cystic changes are particularly rare. We report a case of a 46-year-old man who presented with episodic hypertension and headache. Radiographic studies showed an 18-cm cystic mass in the left upper quadrant of the abdomen; further workups, which included light microscopy, immunohistochemical, and electron microscopic analysis, revealed a pheochromocytoma of the left adrenal gland. Cytogenetic analysis and genetic mutation analyses for von-Hippel-Lindau (VHL), rearranged during transfection (RET), and succinate dehydrogenase complex subunit B (SDHB) genes were also performed but failed to reveal any abnormalities within the tumor cells.

Original language	English (US)
Pages (from-to)	133-138
Number of pages	6
Journal	Endocrine Pathology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1007/s12022-008-9016-4
State	Published - Jun 1 2008

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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AU - Sharma, Poonam

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AB - Adrenal pheochromocytomas are rare catecholamine-secreting tumors that originate from chromaffin cells in the adrenal medulla, and giant pheochromocytomas with cystic changes are particularly rare. We report a case of a 46-year-old man who presented with episodic hypertension and headache. Radiographic studies showed an 18-cm cystic mass in the left upper quadrant of the abdomen; further workups, which included light microscopy, immunohistochemical, and electron microscopic analysis, revealed a pheochromocytoma of the left adrenal gland. Cytogenetic analysis and genetic mutation analyses for von-Hippel-Lindau (VHL), rearranged during transfection (RET), and succinate dehydrogenase complex subunit B (SDHB) genes were also performed but failed to reveal any abnormalities within the tumor cells.

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A giant cystic pheochromocytoma of the adrenal gland

Abstract

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