A large multisite cancer family is linked to BRCA2

P. Tonin, P. Ghadirian, C. Phelan, G. M. Lenoir, Henry T. Lynch, F. Letendre, D. Belanger, M. Monté, S. A. Narod

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Abstract

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

Original languageEnglish
Pages (from-to)982-984
Number of pages3
JournalJournal of Medical Genetics
Volume32
Issue number12
DOIs
Publication statusPublished - 1995

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All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Genetics
  • Genetics(clinical)

Cite this

Tonin, P., Ghadirian, P., Phelan, C., Lenoir, G. M., Lynch, H. T., Letendre, F., ... Narod, S. A. (1995). A large multisite cancer family is linked to BRCA2. Journal of Medical Genetics, 32(12), 982-984. https://doi.org/10.1136/jmg.32.12.982