Abstract
Dental studies often produce spatially referenced multivariate time-to-event data, such as the time until tooth loss due to periodontal disease. These data are used to identify risk factors that are associated with tooth loss, and to predict outcomes for an individual patient. The rate of spatial referencing can vary with various tooth locations. In addition, these event time data are heavily censored, mostly because a certain proportion of teeth in the population are not expected to experience failure and can be considered 'cured'. We assume a proportional hazards model with a surviving fraction to model these clustered correlated data and account for dependence between nearby teeth by using spatial frailties which are modelled as linear combinations of positive stable random effects. This model permits predictions (conditioned on spatial frailties) that account for the survival status of nearby teeth and simultaneously preserves the proportional hazards relationship marginally over the random effects for the susceptible teeth, allowing for interpretable estimates of the effects of risk factors on tooth loss. We explore the potential of this model via simulation studies and application to a real data set obtained from a private periodontal practice, and we illustrate its advantages over other competing models to identify important risk factors for tooth loss and to predict the remaining lifespan of a patient's teeth.
| Original language | English |
|---|---|
| Pages (from-to) | 673-691 |
| Number of pages | 19 |
| Journal | Journal of the Royal Statistical Society. Series C: Applied Statistics |
| Volume | 64 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2015 |
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All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Statistics, Probability and Uncertainty
Cite this
A marginal cure rate proportional hazards model for spatial survival data. / Schnell, Patrick; Bandyopadhyay, Dipankar; Reich, Brian J.; Nunn, Martha E.
In: Journal of the Royal Statistical Society. Series C: Applied Statistics, Vol. 64, No. 4, 01.08.2015, p. 673-691.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A marginal cure rate proportional hazards model for spatial survival data
AU - Schnell, Patrick
AU - Bandyopadhyay, Dipankar
AU - Reich, Brian J.
AU - Nunn, Martha E.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Dental studies often produce spatially referenced multivariate time-to-event data, such as the time until tooth loss due to periodontal disease. These data are used to identify risk factors that are associated with tooth loss, and to predict outcomes for an individual patient. The rate of spatial referencing can vary with various tooth locations. In addition, these event time data are heavily censored, mostly because a certain proportion of teeth in the population are not expected to experience failure and can be considered 'cured'. We assume a proportional hazards model with a surviving fraction to model these clustered correlated data and account for dependence between nearby teeth by using spatial frailties which are modelled as linear combinations of positive stable random effects. This model permits predictions (conditioned on spatial frailties) that account for the survival status of nearby teeth and simultaneously preserves the proportional hazards relationship marginally over the random effects for the susceptible teeth, allowing for interpretable estimates of the effects of risk factors on tooth loss. We explore the potential of this model via simulation studies and application to a real data set obtained from a private periodontal practice, and we illustrate its advantages over other competing models to identify important risk factors for tooth loss and to predict the remaining lifespan of a patient's teeth.
AB - Dental studies often produce spatially referenced multivariate time-to-event data, such as the time until tooth loss due to periodontal disease. These data are used to identify risk factors that are associated with tooth loss, and to predict outcomes for an individual patient. The rate of spatial referencing can vary with various tooth locations. In addition, these event time data are heavily censored, mostly because a certain proportion of teeth in the population are not expected to experience failure and can be considered 'cured'. We assume a proportional hazards model with a surviving fraction to model these clustered correlated data and account for dependence between nearby teeth by using spatial frailties which are modelled as linear combinations of positive stable random effects. This model permits predictions (conditioned on spatial frailties) that account for the survival status of nearby teeth and simultaneously preserves the proportional hazards relationship marginally over the random effects for the susceptible teeth, allowing for interpretable estimates of the effects of risk factors on tooth loss. We explore the potential of this model via simulation studies and application to a real data set obtained from a private periodontal practice, and we illustrate its advantages over other competing models to identify important risk factors for tooth loss and to predict the remaining lifespan of a patient's teeth.
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U2 - 10.1111/rssc.12098
DO - 10.1111/rssc.12098
M3 - Article
AN - SCOPUS:84934805701
VL - 64
SP - 673
EP - 691
JO - Journal of the Royal Statistical Society. Series C: Applied Statistics
JF - Journal of the Royal Statistical Society. Series C: Applied Statistics
SN - 0035-9254
IS - 4
ER -