Abstract
Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 443-452 |
| Number of pages | 10 |
| Journal | Childhood Obesity |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 1 2018 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity. / Mirza, Nazrat; Phan, Thao Ly; Tester, June; Fals, Angela; Fernández, Cristina F.; Datto, George; Estrada, Elizabeth; Eneli, Ihuoma.
In: Childhood Obesity, Vol. 14, No. 7, 01.10.2018, p. 443-452.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity
AU - Mirza, Nazrat
AU - Phan, Thao Ly
AU - Tester, June
AU - Fals, Angela
AU - Fernández, Cristina F.
AU - Datto, George
AU - Estrada, Elizabeth
AU - Eneli, Ihuoma
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.
AB - Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.
UR - http://www.scopus.com/inward/record.url?scp=85053933581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053933581&partnerID=8YFLogxK
U2 - 10.1089/chi.2017.0350
DO - 10.1089/chi.2017.0350
M3 - Review article
C2 - 29791184
AN - SCOPUS:85053933581
VL - 14
SP - 443
EP - 452
JO - Childhood Obesity
JF - Childhood Obesity
SN - 2153-2168
IS - 7
ER -