A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity

Nazrat Mirza, Thao Ly Phan, June Tester, Angela Fals, Cristina F. Fernández, George Datto, Elizabeth Estrada, Ihuoma Eneli

Research output: Contribution to journalReview article

  • 3 Citations

Abstract

Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.

LanguageEnglish (US)
Pages443-452
Number of pages10
JournalChildhood Obesity
Volume14
Issue number7
DOIs
StatePublished - Oct 1 2018
Externally publishedYes

Fingerprint

Morbid Obesity
Medical Genetics
Weight Gain
Mothers
Gestational Diabetes
Pediatric Obesity
Vulnerable Populations
Fatty Liver
Dyslipidemias
Liver Diseases
Body Mass Index
Obesity
Smoking
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity. / Mirza, Nazrat; Phan, Thao Ly; Tester, June; Fals, Angela; Fernández, Cristina F.; Datto, George; Estrada, Elizabeth; Eneli, Ihuoma.

In: Childhood Obesity, Vol. 14, No. 7, 01.10.2018, p. 443-452.

Research output: Contribution to journalReview article

Mirza, Nazrat ; Phan, Thao Ly ; Tester, June ; Fals, Angela ; Fernández, Cristina F. ; Datto, George ; Estrada, Elizabeth ; Eneli, Ihuoma. / A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity. In: Childhood Obesity. 2018 ; Vol. 14, No. 7. pp. 443-452.
@article{719148b4e3d34a6ebde1b9ed8589de7e,
title = "A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity",
abstract = "Severe obesity defined as an age-and gender-specific body mass index ≥120{\%} of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.",
author = "Nazrat Mirza and Phan, {Thao Ly} and June Tester and Angela Fals and Fern{\'a}ndez, {Cristina F.} and George Datto and Elizabeth Estrada and Ihuoma Eneli",
year = "2018",
month = "10",
day = "1",
doi = "10.1089/chi.2017.0350",
language = "English (US)",
volume = "14",
pages = "443--452",
journal = "Childhood Obesity",
issn = "2153-2168",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity

AU - Mirza, Nazrat

AU - Phan, Thao Ly

AU - Tester, June

AU - Fals, Angela

AU - Fernández, Cristina F.

AU - Datto, George

AU - Estrada, Elizabeth

AU - Eneli, Ihuoma

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.

AB - Severe obesity defined as an age-and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.

UR - http://www.scopus.com/inward/record.url?scp=85053933581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053933581&partnerID=8YFLogxK

U2 - 10.1089/chi.2017.0350

DO - 10.1089/chi.2017.0350

M3 - Review article

VL - 14

SP - 443

EP - 452

JO - Childhood Obesity

T2 - Childhood Obesity

JF - Childhood Obesity

SN - 2153-2168

IS - 7

ER -