A novel in situ gel for sustained drug delivery and targeting

Sudipta Ganguly, Alekha K. Dash

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The objective of this study was to develop a novel chitosan-glyceryl monooleate (GMO) in situ gel system for sustained drug delivery and targeting. The delivery system consisted of 3% (w/v) chitosan and 3% (w/v) GMO in 0.33 M citric acid. In situ gel was formed at a biological pH. In vitro release studies were conducted in Sorensen's phosphate buffer (pH 7.4) and drugs were analyzed either by HPLC or spectrophotometry. Characterization of the gel included the effect of cross-linker, determination of diffusion coefficient and water uptake by thermogravimetric analysis (TGA). Mucoadhesive property of the gel was evaluated in vitro using an EZ-Tester. Incorporation of a cross-linker (glutaraldehyde) retarded the rate and extent of drug release. The in vitro release can further be sustained by replacing the free drug with drug-encapsulated microspheres. Drug release from the gel followed a matrix diffusion controlled mechanism. Inclusion of GMO enhanced the mucoadhesive property of chitosan by three- to sevenfold. This novel in situ gel system can be useful in the sustained delivery of drugs via oral as well as parenteral routes.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume276
Issue number1-2
DOIs
StatePublished - May 19 2004

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Drug Delivery Systems
Gels
Chitosan
Pharmaceutical Preparations
Spectrophotometry
Glutaral
Microspheres
Citric Acid
Buffers
Phosphates
High Pressure Liquid Chromatography
Water
In Vitro Techniques
monoolein

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

A novel in situ gel for sustained drug delivery and targeting. / Ganguly, Sudipta; Dash, Alekha K.

In: International Journal of Pharmaceutics, Vol. 276, No. 1-2, 19.05.2004, p. 83-92.

Research output: Contribution to journalArticle

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