A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

S. L. Neuhausen, J. Swensen, Y. Miki, Q. Llu, S. Tavtiglan, D. Shattuck-eidens, A. Kamb, M. R. Hobbs, J. Gingrich, H. Shizuya, U. J. Kim, C. Cochran, P. A. Futreal, R. W. Wiseman, Henry T. Lynch, P. Tonin, S. Narod, L. Cannon-albright, M. H. Skolnick, D. E. Goldgar

Research output: Contribution to journalArticle

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Abstract

BRCA1, a breast and ovarian cancer susceptibility locus, has been isolated and maps to 17q21. A physical map of the BRCA1, region which extended from the proximal boundary at D17S776 to the distal boundary at D17S78 was constructed and consists of 51 sequence tagged sites (STSs) from P1 and YAC ends, nine new short-tandem repeat (STR) polymorphic markers, and eight identified genes. The contig, which spans the estimated 2.3 Mb region, contains 29 P1s, 11 YACs, two BACs, and one cosmid. Based on key recombinants in two linked families, BRCA1 was further localized to a region bounded by D17S1321 on the proximal side and D17S1325 on the distal side. Within this estimated 600 kb region, the contig was composed completely of P1s and BACs ordered by STS-content mapping and confirmed by DNA restriction fragment fingerprinting.

Original languageEnglish
Pages (from-to)1919-1926
Number of pages8
JournalHuman Molecular Genetics
Volume3
Issue number11
DOIs
StatePublished - Nov 1994

Fingerprint

Sequence Tagged Sites
Neoplasm Genes
Breast Cancer
Susceptibility
Genes
Breast Neoplasms
Gene
Cosmids
Microsatellite Repeats
Ovarian Neoplasms
DNA
Ovarian Cancer
Fingerprinting
Locus
Fragment
Restriction
Breast cancer

All Science Journal Classification (ASJC) codes

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Genetics(clinical)
  • Genetics

Cite this

Neuhausen, S. L., Swensen, J., Miki, Y., Llu, Q., Tavtiglan, S., Shattuck-eidens, D., ... Goldgar, D. E. (1994). A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1. Human Molecular Genetics, 3(11), 1919-1926. https://doi.org/10.1093/hmg/3.11.1919

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1. / Neuhausen, S. L.; Swensen, J.; Miki, Y.; Llu, Q.; Tavtiglan, S.; Shattuck-eidens, D.; Kamb, A.; Hobbs, M. R.; Gingrich, J.; Shizuya, H.; Kim, U. J.; Cochran, C.; Futreal, P. A.; Wiseman, R. W.; Lynch, Henry T.; Tonin, P.; Narod, S.; Cannon-albright, L.; Skolnick, M. H.; Goldgar, D. E.

In: Human Molecular Genetics, Vol. 3, No. 11, 11.1994, p. 1919-1926.

Research output: Contribution to journalArticle

Neuhausen, SL, Swensen, J, Miki, Y, Llu, Q, Tavtiglan, S, Shattuck-eidens, D, Kamb, A, Hobbs, MR, Gingrich, J, Shizuya, H, Kim, UJ, Cochran, C, Futreal, PA, Wiseman, RW, Lynch, HT, Tonin, P, Narod, S, Cannon-albright, L, Skolnick, MH & Goldgar, DE 1994, 'A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1', Human Molecular Genetics, vol. 3, no. 11, pp. 1919-1926. https://doi.org/10.1093/hmg/3.11.1919
Neuhausen, S. L. ; Swensen, J. ; Miki, Y. ; Llu, Q. ; Tavtiglan, S. ; Shattuck-eidens, D. ; Kamb, A. ; Hobbs, M. R. ; Gingrich, J. ; Shizuya, H. ; Kim, U. J. ; Cochran, C. ; Futreal, P. A. ; Wiseman, R. W. ; Lynch, Henry T. ; Tonin, P. ; Narod, S. ; Cannon-albright, L. ; Skolnick, M. H. ; Goldgar, D. E. / A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1. In: Human Molecular Genetics. 1994 ; Vol. 3, No. 11. pp. 1919-1926.
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