A Pharmacological/Physiological Comparison of Metformin and Exercise

Thomas L. Lenz, Matthew R. Seyer

Research output: Contribution to journalArticle

Abstract

Type 2 diabetes is a significant health concern in the United States and its prevalence is expected to triple by 2050. Both metformin and exercise have shown to be effective in the management of blood glucose control. The pharmacological mechanism of action of metformin is largely based on the activation of AMPK to induce glucose transport. Likewise, the physiological actions of exercise appear to be a potent activator of AMPK, resulting in glucose uptake by the muscle. Research shows that metformin may control blood glucose slightly better than exercise in persons with type 2 diabetes. However, it appears that lifestyle interventions outperform metformin when trying to prevent the onset of diabetes. Both metformin and exercise have a positive and significant role in the management of type 2 diabetes and appear to work similarly to help manage blood glucose control.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalAmerican Journal of Lifestyle Medicine
Volume7
Issue number2
DOIs
StatePublished - 2013

Fingerprint

Metformin
Pharmacology
Type 2 Diabetes Mellitus
Blood Glucose
AMP-Activated Protein Kinases
Molecular Mechanisms of Pharmacological Action
Glucose
Life Style
Muscles
Health
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

A Pharmacological/Physiological Comparison of Metformin and Exercise. / Lenz, Thomas L.; Seyer, Matthew R.

In: American Journal of Lifestyle Medicine, Vol. 7, No. 2, 2013, p. 118-120.

Research output: Contribution to journalArticle

@article{a742483a0086425286f95dc31b9bdf77,
title = "A Pharmacological/Physiological Comparison of Metformin and Exercise",
abstract = "Type 2 diabetes is a significant health concern in the United States and its prevalence is expected to triple by 2050. Both metformin and exercise have shown to be effective in the management of blood glucose control. The pharmacological mechanism of action of metformin is largely based on the activation of AMPK to induce glucose transport. Likewise, the physiological actions of exercise appear to be a potent activator of AMPK, resulting in glucose uptake by the muscle. Research shows that metformin may control blood glucose slightly better than exercise in persons with type 2 diabetes. However, it appears that lifestyle interventions outperform metformin when trying to prevent the onset of diabetes. Both metformin and exercise have a positive and significant role in the management of type 2 diabetes and appear to work similarly to help manage blood glucose control.",
author = "Lenz, {Thomas L.} and Seyer, {Matthew R.}",
year = "2013",
doi = "10.1177/1559827612465576",
language = "English",
volume = "7",
pages = "118--120",
journal = "American Journal of Lifestyle Medicine",
issn = "1559-8276",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - A Pharmacological/Physiological Comparison of Metformin and Exercise

AU - Lenz, Thomas L.

AU - Seyer, Matthew R.

PY - 2013

Y1 - 2013

N2 - Type 2 diabetes is a significant health concern in the United States and its prevalence is expected to triple by 2050. Both metformin and exercise have shown to be effective in the management of blood glucose control. The pharmacological mechanism of action of metformin is largely based on the activation of AMPK to induce glucose transport. Likewise, the physiological actions of exercise appear to be a potent activator of AMPK, resulting in glucose uptake by the muscle. Research shows that metformin may control blood glucose slightly better than exercise in persons with type 2 diabetes. However, it appears that lifestyle interventions outperform metformin when trying to prevent the onset of diabetes. Both metformin and exercise have a positive and significant role in the management of type 2 diabetes and appear to work similarly to help manage blood glucose control.

AB - Type 2 diabetes is a significant health concern in the United States and its prevalence is expected to triple by 2050. Both metformin and exercise have shown to be effective in the management of blood glucose control. The pharmacological mechanism of action of metformin is largely based on the activation of AMPK to induce glucose transport. Likewise, the physiological actions of exercise appear to be a potent activator of AMPK, resulting in glucose uptake by the muscle. Research shows that metformin may control blood glucose slightly better than exercise in persons with type 2 diabetes. However, it appears that lifestyle interventions outperform metformin when trying to prevent the onset of diabetes. Both metformin and exercise have a positive and significant role in the management of type 2 diabetes and appear to work similarly to help manage blood glucose control.

UR - http://www.scopus.com/inward/record.url?scp=84875408301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875408301&partnerID=8YFLogxK

U2 - 10.1177/1559827612465576

DO - 10.1177/1559827612465576

M3 - Article

VL - 7

SP - 118

EP - 120

JO - American Journal of Lifestyle Medicine

JF - American Journal of Lifestyle Medicine

SN - 1559-8276

IS - 2

ER -