A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females

Li Na He, Robert R. Recker, Hong Wen Deng, Volodymyr Dvornyk

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. Design: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. Results: Alcohol consumption was a significantly predictor of earlier natural menopause (P <0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P = 0.007 and 0.046, respectively). However, no association was observed between APOE ε2, ε3, ε4 and ANM. Conclusions: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalMaturitas
Volume62
Issue number1
DOIs
StatePublished - Jan 20 2009

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Apolipoproteins E
Menopause
Polymorphism
Genes
Apolipoprotein E2
Single Nucleotide Polymorphism
Alcohols
Apolipoprotein E3
Alcohol Drinking
Population

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Biochemistry, Genetics and Molecular Biology(all)

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A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. / He, Li Na; Recker, Robert R.; Deng, Hong Wen; Dvornyk, Volodymyr.

In: Maturitas, Vol. 62, No. 1, 20.01.2009, p. 37-41.

Research output: Contribution to journalArticle

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