Abstract
This article suggests that calcium acts as an intermediate for intestinal fluid secretion mediated by adenosine-3′:5′-cyclic monophosphoric acid (cAMP) and guanosine -3′:5′-cyclic monophosphoric acid (cGMP). It is hypothesized that microbial enterotoxins disrupt the normal interrelationships between calcium and cyclic nucleotides, thereby leading to adverse biological effects. It is further proposed that the inhibitory effect of chlorpromazine on calmodulin accounts for the ability of this drug to inhibit enterotoxins which separately elevate cAMP or cGMP concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 719-727 |
| Number of pages | 9 |
| Journal | Medical Hypotheses |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1981 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Medicine(all)
- Drug Discovery
Cite this
A possible role for calcium in cyclic nucleotide mediated fluid secretion. / Knoop, Floyd C.; Abbey, D. M.
In: Medical Hypotheses, Vol. 7, No. 6, 01.01.1981, p. 719-727.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible role for calcium in cyclic nucleotide mediated fluid secretion
AU - Knoop, Floyd C.
AU - Abbey, D. M.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - This article suggests that calcium acts as an intermediate for intestinal fluid secretion mediated by adenosine-3′:5′-cyclic monophosphoric acid (cAMP) and guanosine -3′:5′-cyclic monophosphoric acid (cGMP). It is hypothesized that microbial enterotoxins disrupt the normal interrelationships between calcium and cyclic nucleotides, thereby leading to adverse biological effects. It is further proposed that the inhibitory effect of chlorpromazine on calmodulin accounts for the ability of this drug to inhibit enterotoxins which separately elevate cAMP or cGMP concentrations.
AB - This article suggests that calcium acts as an intermediate for intestinal fluid secretion mediated by adenosine-3′:5′-cyclic monophosphoric acid (cAMP) and guanosine -3′:5′-cyclic monophosphoric acid (cGMP). It is hypothesized that microbial enterotoxins disrupt the normal interrelationships between calcium and cyclic nucleotides, thereby leading to adverse biological effects. It is further proposed that the inhibitory effect of chlorpromazine on calmodulin accounts for the ability of this drug to inhibit enterotoxins which separately elevate cAMP or cGMP concentrations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019828107&partnerID=8YFLogxK
U2 - 10.1016/0306-9877(81)90083-9
DO - 10.1016/0306-9877(81)90083-9
M3 - Article
C2 - 6116167
AN - SCOPUS:0019828107
VL - 7
SP - 719
EP - 727
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 6
ER -