A possible role for calcium in cyclic nucleotide mediated fluid secretion

Floyd C. Knoop, D. M. Abbey

Research output: Contribution to journalArticle

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Abstract

This article suggests that calcium acts as an intermediate for intestinal fluid secretion mediated by adenosine-3′:5′-cyclic monophosphoric acid (cAMP) and guanosine -3′:5′-cyclic monophosphoric acid (cGMP). It is hypothesized that microbial enterotoxins disrupt the normal interrelationships between calcium and cyclic nucleotides, thereby leading to adverse biological effects. It is further proposed that the inhibitory effect of chlorpromazine on calmodulin accounts for the ability of this drug to inhibit enterotoxins which separately elevate cAMP or cGMP concentrations.

Original languageEnglish (US)
Pages (from-to)719-727
Number of pages9
JournalMedical Hypotheses
Volume7
Issue number6
DOIs
Publication statusPublished - Jan 1 1981

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All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

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