TY - JOUR
T1 - A review of electrogenerated chemiluminescent biosensors for assays in biological matrices
AU - Gross, Erin M.
AU - Maddipati, Sai Sujana
AU - Snyder, Sarah M.
N1 - Funding Information:
This publication was made possible by grants from the National Institute for General Medical Science (NIGMS) (5P20GM103427), a component of the NIH, and its contents are the sole responsibility of the authors and do not necessarily represent the official views of NIGMS or NIH.
PY - 2016/10
Y1 - 2016/10
N2 - Electrogenerated chemiluminescence (ECL) is the production of light via electron transfer reactions between electrochemically produced reagents. ECL-based biosensors use specific biological interactions to recognize an analyte and produce a luminescent signal. Biosensors fabricated with novel biorecognition species have increased the number of analytes detected. Some of these analytes include peptides, cells, enzymes and nucleic acids. ECL biosensors are selective, simple, sensitive and have low detection limits. Traditional methods use ruthenium complexes or luminol to generate ECL. Nanomaterials can be incorporated into ECL biosensors to improve efficiency, but also represent a new class of ECL emitters. This article reviews the application of ruthenium complex, luminol and nanomaterial-based ECL biosensors to making measurements in biological matrices over the past 4 years.
AB - Electrogenerated chemiluminescence (ECL) is the production of light via electron transfer reactions between electrochemically produced reagents. ECL-based biosensors use specific biological interactions to recognize an analyte and produce a luminescent signal. Biosensors fabricated with novel biorecognition species have increased the number of analytes detected. Some of these analytes include peptides, cells, enzymes and nucleic acids. ECL biosensors are selective, simple, sensitive and have low detection limits. Traditional methods use ruthenium complexes or luminol to generate ECL. Nanomaterials can be incorporated into ECL biosensors to improve efficiency, but also represent a new class of ECL emitters. This article reviews the application of ruthenium complex, luminol and nanomaterial-based ECL biosensors to making measurements in biological matrices over the past 4 years.
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U2 - 10.4155/bio-2016-0178
DO - 10.4155/bio-2016-0178
M3 - Review article
C2 - 27611228
AN - SCOPUS:84988672619
VL - 8
SP - 2071
EP - 2089
JO - Bioanalysis
JF - Bioanalysis
SN - 1757-6180
IS - 19
ER -