A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

Abhijit A. Date, Christopher J. Destache

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.

Original languageEnglish
Pages (from-to)6202-6228
Number of pages27
JournalBiomaterials
Volume34
Issue number26
DOIs
StatePublished - Aug 2013

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Acquired Immunodeficiency Syndrome
Tenofovir
HIV
Vaccines
Liposomes
Dendrimers
Nucleic acids
Nanofibers
Nanotechnology
Pharmaceutical Preparations
Nanocrystals
Lipids
AIDS Vaccines
Nanoparticles
Availability
HIV Infections
Nucleic Acids
Small Interfering RNA
Pandemics
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

A review of nanotechnological approaches for the prophylaxis of HIV/AIDS. / Date, Abhijit A.; Destache, Christopher J.

In: Biomaterials, Vol. 34, No. 26, 08.2013, p. 6202-6228.

Research output: Contribution to journalReview article

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